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Acute Rise of Pancreatic Polypeptide after Electroconvulsive Therapy

Published online by Cambridge University Press:  29 January 2018

J. M. Allen ,
T. E. Adrian ,
P. A. Cramer ,
J. Steinert  and
S. R. Bloom
J. M. Allen
Affiliation:
Hammersmith Hospital, Du Cane Road, London, W12
T. E. Adrian
Affiliation:
Department of Medicine, Royal Postgraduate Medical School, London, W12
P. A. Cramer
Affiliation:
St Bernards Hospital, Southall, Middlesex
J. Steinert
Affiliation:
St Bernards Hospital, Southall, Middlesex
S. R. Bloom
Affiliation:
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12
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Summary

Plasma pancreatic polypeptide concentrations rise by 320±81 per cent following administration of electroconvulsive therapy. This rise is observed in the first ten minutes despite premedication of patients with 0.6 mg atropine. Pancreatic polypeptide release is dependent on cholinergic tone and is very sensitive to atropine. The dramatic rise in pancreative polypeptide observed following electroconvulsive therapy probably results from vagal stimulation and reflects insufficient atropine premedication.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 1 , July 1982 , pp. 24 - 26
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Adrian, T. E., Bloom, S. R., Bryant, M. G., Polak, J. M., Hertz, Ph. & Barnes, A. J. (1976) Distribution and release of human pancreatic polypeptide. Gut, 17, 940–4.Google Scholar
Adrian, T. E., Bloom, S. R., Besternan, H. S., Barnes, A. J., Cooke, T. J. C., Russell, R. C. G. & Faber, R. G. (1977) Mechanism of pancreatic polypeptide release in man. Lancet, i, 161–3.Google Scholar
Adrian, T. E., Besterman, H. S. & Bloom, S. R. (1979) The importance of cholinergic tone in the release of PP by gut hormones in man. Life Science, 24, 1989–94.Google Scholar
Adrian, T. E., Greenberg, G. R. & Bloom, S. R. (1981) Actions of pancreatic polypeptide in man. In Gut Hormones, 2nd Edition (eds. Bloom, S. R. and Polak, J. M.). Edinburgh: Churchill Livingstone Google Scholar
Bankhead, A. J., Torrens, J. K. & Harris, T. H. (1950) The anticipation and prevention of cardiac complications in electroconvulsive therapy: A clinical and electrocardiographic study. American Journal of Psychiatry, 124, 395–6.Google Scholar
British Medical Journal (Leader) (1980) 281, 1588.Google Scholar
Delitala, G., Masala, A., Rosati, G., Aiello, I. & Agnetti, V. (1977) Effect of electroconvulsive therapy (electro shock) on plasma ACTH, GH, LH, FSH, TSH and 11–OHCS in patients with mental disorders. Paraminerva Medico, 19, 237–43.Google Scholar
Floyd, J. C. Jr., Vinik, A. I., Glaser, B., Fajans, S. S. & Pek, S. (1980) Atropine causes acute and complete cessation of human pancreatic polypeptide release induced by protein meals. In Pancreatic Polypeptide 490–95 (ed. Waldhaus, W. K.). International Congress Series No. 500, Amsterdam.Google Scholar
Gelhorn, E. & Loofbouvrow, G. N. (1963) Emotions and Emotional Disorders. New York: Harper and Row.Google Scholar
Larsson, L. I., Sundler, F. & Hakanson, R. (1975) Immunohistochemical localisation of human pancreatic polypeptide (HPP) to a population of islet cells. Cell and Tissue Research, 156, 167–71.Google Scholar
Modlin, I. M., Lamers, C. B. & Jaffe, B. M. (1980) Evidence for cholinergic dependence of PP release by bombesin—a possible application. Surgery, 88, 75–85.Google Scholar
Perrin, G. M. (1961) Cardiovascular aspects of electric shock therapy. Acta Psychiatrica et Neurologica Scandinavica, Suppl 36, 7–45.Google Scholar
Schwartz, T. W., Stenquist, B. & Olbe, L. (1978) Physiology of mammalian PP and the importance of vagal regulation. In Gut Hormones 261–64, 1st edition (ed. Bloom, S. R.). Edinburgh: Churchill Livingstone Google Scholar
Schwartz, T. W., Holst, J. J., Fakrenkrug, J., Lindkaer-Jensen, S., Nielson, O. V., Rehfeld, J. F., Schaffalitzky, , de Muckadell, D. B. & Stadil, F. (1978) Vagal cholinergic regulation of PP secretion. Journal of Clinical Investigation, 61, 781–9.Google Scholar
Schwartz, T. W. (1979) Pancreatic polypeptide as indicator of vagal activity. In Gastrins and the Vagus, 175–79 (eds. Rehfeld, J. F. and Androp, E.). New York: Academic Press Google Scholar
Skvabanek, P., Balfe, A., Webb, M., Maguire, J. & Powell, D. (1981) Electroconvulsive therapy (ECT) increased plasma growth hormone, prolactin, luteinising hormone and follicle stimulating hormone but not thyrotorphin or substance P. Psychoneuroendocrinology, 6, 261–7.Google Scholar
Taylor, I. L., Impicciatore, M. & Walsh, J. M. (1977) Effect of atropine and vagotomy on the pancreatic polypeptide response to a meal. Gastroenterology, 72, 1116–39.Google Scholar
Taylor, I. L., Impicciatore, M. Carter, D. C. & Walsh, J. H. (1978) Effect of atropine and vagotomy on PP response to a meal in dogs. American Journal of Physiology, 275, 443–8.Google Scholar
Whitwam, J. G. & Moreton, Norman J. (1963) Clinical signs with modified electroconvulsive therapy. British Journal of Psychiatry, 109, 399–413.Google Scholar
Ylikorkala, O., Kaupilla, , Haapalauthi, J. & Karppanen, H. (1976) The effects of electroconvulsive therapy on circulating concentrations of pituitary hormones, Cortisol and cyclic adenosine monophosphate. Clinical Endocrinology, 5, 571–4.CrossRefGoogle ScholarPubMed
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