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Prevalence of spontaneous dyskinesia in schizophrenic and non-schizophrenic psychiatric patients

Published online by Cambridge University Press:  03 January 2018

Wayne S. Fenton*
Affiliation:
Chestnut Lodge Research Institute, Rockville, Maryland, USA
Crystal R. Blyler
Affiliation:
Chestnut Lodge Research Institute, Rockville, Maryland, USA
Richard J. Wyatt
Affiliation:
Neuropsychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
Thomas H. McGlashan
Affiliation:
Yale Psychiatric Institute, New Haven, Connecticut, USA
*
Wayne S. Fenton, Director of Research, Chestnut Lodge Research Institute, 500 West Montgomery Avenue, Rockville. MD 20850. USA. Fax: (301) 309-0915

Abstract

Background

Although movement disorders have been noted among patients never exposed to neuroleptic medications, the specificity of spontaneous dyskinesia to schizophrenia has rarely been examined.

Method

By abstracting detailed case records, we compared the prevalence of dyskinetic movements between 94 neuroleptic-naïve schizophrenic patients and 179 patients with other psychiatric disorders.

Results

Dyskinetic movements were more common among patients with schizophrenia than among those with all other diagnoses, and were most often noted in the body areas typically associated with tardive dyskinesia.

Conclusions

Spontaneous dyskinesia appears to be relatively specific to schizophrenia and may be intrinsic to the pathophysiology of the disorder.

Type
Papers
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Barnes, T. R. E., Rossor, M. & Trauar, T. (1983) A comparison of purposeless movements in psychiatric patients treated with antipsychotic drugs, and normal individuals. Journal of Neurology, Neurosurgery and Psychiatry, 46, 540546.CrossRefGoogle ScholarPubMed
Caligiuri, M. P., Lohr, J. B. & Jeste, D. V. (1993) Parkinsonism in neuroleptic-naive schizophrenic patients. American Journal of Psychiatry, 150, 13431348.Google Scholar
Caligiuri, M. P., & Lohr, J. B. (1994) A disturbance in the control of muscle force in neuroleptic-naive schizophrenic patients. Biological Psychiatry, 35, 104111.Google Scholar
Chatterjee, A., Chakos, M., Korean, A., et al (1995) Prevalence and clinical correlates of extrapyramidal signs and spontaneous dyskinesia in never-medicated schizophrenic patients. American Journal of Psychiatry, 152, 17241729.Google ScholarPubMed
Chorfi, M. & Moussaoui, D. (1989) Lack of dyskinesias in unmedicated schizophrenics. Psychopharmacology, 97, 423.Google Scholar
Fenton, W. S. & McGlashan, T. H. (1991a) Natural history of schizophrenia subtypes: I. Longitudinal study of paranoid, hebephrenic, and undifferentiated schizophrenia. Archives of General Psychiatry, 48, 969977.Google Scholar
Fenton, W. S. & McGlashan, T. H. (1991b) Natural history of schizophrenia subtypes: II. Positive and negative symptoms and long-term course. Archives of General Psychiatry, 48, 978986.CrossRefGoogle ScholarPubMed
Fenton, W. S., Wyatt, R. J. & McGlashan, T. H. (1994) Risk factors for spontaneous dyskinesia in schizophrenia. Archives of General Psychiatry, 51, 643650.Google Scholar
Gupta, S., Andreasen, N. C., Arndt, S., et al (1995) Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. American Journal of Psychiatry, 152, 191196.Google Scholar
Kane, J. M., Weinhold, P., Kinon, B., et al (1982) Prevalence of abnormal involuntary movements (“spontaneous dyskinesias”) in the normal elderly. Psychopharmacology, 77, 105108.Google Scholar
Klawans, H. L. & Barr, A. (1982) Prevalence of spontaneous lingual-facial-buccal dyskinesias in the elderly. Neurology, 32, 558559.Google Scholar
Lieberman, J., Kane, J. M., Woerner, M., et al (1984) Prevalence of tardive dyskinesia in elderly samples. Psychopharmacology Bulletin, 20, 382386.Google Scholar
McCreadie, R. G., Barron, E. T. & Winslow, G. S. (1982) The Nithsdale schizophrenia survey: II. Abnormal movements. British Journal of Psychiatry, 140, 587590.Google Scholar
McCreadie, R. G. & Ohaeri, J. U. (1994) Movement disorder in never and minimally treated Nigerian schizophrenic patients. British Journal of Psychiatry, 164, 184189.Google Scholar
McGlashan, T. H. (1984a) The Chestnut Lodge Follow-up Study: I. Follow-up methodology and study sample. Archives of General Psychiatry, 41, 573585.Google Scholar
McGlashan, T. H. (1984b) The Chestnut Lodge Follow-up Study: II. Long term outcome of schizophrenia and the affective disorders. Archives of General Psychiatry, 41, 586601.Google Scholar
Owens, D. G. C. (1985) Involuntary disorders of movement in chronic schizophrenia: the role of the illness and its treatment. Psychopharmacology, 2 (suppl.), 7987.Google Scholar
Owens, D. G. C. & Johnstone, E. C. (1980) The disabilities of chronic schizophrenia: their nature and the factors contributing to their development. British Journal of Psychiatry, 136, 384395.CrossRefGoogle Scholar
Owens, D. G. C., & Frith, C. D. (1982) Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics. Archives of General Psychiatry, 39, 452461.CrossRefGoogle ScholarPubMed
Turner, T. (1989) Rich and mad in Victorian England. Psychological Medicine, 19, 2944.Google Scholar
Waddington, J. L. (1989) Schizophrenia, affective psychoses, and other disorders treated with neuroleptic drugs: the enigma of tardive dyskinesia, its neurobiological determinants, and the conflict of paradigms. International Review of Neurobiology, 31, 297353.Google Scholar
Waddington, J. L. & Crow, T. J. (1988) Abnormal involuntary movements and psychosis in the preneuroleptic era and in unmedicated patients: implications for the concept of tardive dyskinesia. In Tardive Dyskinesia: Biological Mechanisms and Clinical Aspects, (eds M. E. Wolf & A. D. Mosnaim), pp. 5166. Washington, DC: American Psychiatric Press.Google Scholar
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