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Derealization Syndrome and the Outcome of Schizophrenia: A Report from the International Pilot Study of Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Hai-Gwo Hwu*
Department of Mental Health, Taipei City Psychiatric Center, 54, Lane 151, Sec. 5, Shin- Yi Road, Taipei, Taiwan, 105, R.O.C.; National Taiwan University College of Medicine, Taipei, Taiwan, R.O.C.
Chu-Chang Chen
National Taiwan University College of Medicine, and National Taiwan University Hospital, Taipei, Taiwan, R.O.C.
Ming Tso Tsuang
University of Iowa College of Medicine, U.S.A.
Wen-Shing Tseng
Department of Psychiatry, University of Hawaii College of Medicine, U.S.A.


Eighty-five schizophrenic patients were found to have worse two-year follow-up outcome (history of remission, clinical course, improvement in psychotic symptoms, general treatment result) than 39 non-schizophrenic psychotic patients. The outcome of 36 schizophrenic patients with derealization at initial evaluation, especially when nine hebephrenics were excluded, was better than that of 49 schizophrenic patients without derealization but similar to that of 39 non-schizophrenic patients. The hebephrenics with derealization demonstrated similar outcomes to schizophrenic patients without derealization. In non-schizophrenic patients, derealization had no prognostic significance.

Research Article
Copyright © Royal College of Psychiatrists, 1981 

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