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Interpreting Heritability Causally

Published online by Cambridge University Press:  01 January 2022

Kate E. Lynch  and
Pierrick Bourrat
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Abstract

A high heritability estimate usually corresponds to a situation in which trait variation is largely caused by genetic variation. However, in some cases of gene-environment covariance, causal intuitions about the sources of trait difference can vary, leading experts to disagree as to how the heritability estimate should be interpreted. We argue that the source of contention for these cases is an inconsistency in the interpretation of the concepts ‘genotype’, ‘phenotype’, and ‘environment’. We propose an interpretation of these terms under which trait variance initially caused by genetic variance is subsumed into a heritability for all cases of gene-environment covariance.

Type
Research Article
Information
Philosophy of Science , Volume 84 , Issue 1 , January 2017 , pp. 14 - 34
Copyright
Copyright © The Philosophy of Science Association

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Footnotes

†

Author order has been decided randomly; therefore, both authors are first authors. KEL and PB contributed equally to the manuscript. KEL’s distinct contribution was the ideas developed in sec. 3. PB’s distinct contribution was the ideas developed in secs. 4 and 5 and the equations in sec. 3. Other sections received equal contributions from both authors. We thank Ingo Brigandt, Paul Griffiths, Wesley Fang, Darrell Kemp, Christopher Lean, Qiaoying Lu, John Matthewson, Arnaud Pocheville, Isobel Ronai, and Karola Stotz for their comments on earlier versions of this article. PB was supported under the Australian Research Council’s Discovery Projects funding scheme DP150102875.

References

Alicke, Mark D. 1992. “Culpable Causation.” Journal of Personality and Social Psychology 63:368–78.CrossRefGoogle Scholar
Baron, Marcia. 2001. “Crime, Genes and Responsibility.” In Genetics and Criminal Behaviour, ed. Wasserman, David and Wachbroit, Robert, 199–224. Cambridge: Cambridge University Press.Google Scholar
Block, Ned. 1995. “How Heritability Misleads about Race.” Cognition 56 (2): 99–128.CrossRefGoogle ScholarPubMed
Block, Ned, and Dworkin, Gerald. 1974. “IQ, Heritability and Inequality.” Pt. 2. Philosophy and Public Affairs 4 (1): 40–99.Google Scholar
Bourrat, Pierrick. 2015. “How to Read ‘Heritability’ in the Recipe Approach to Natural Selection.” British Journal for the Philosophy of Science 66 (4): 883–903.CrossRefGoogle Scholar
Bourrat, Pierrick, and Lu, Q.. Forthcoming. “Dissolving the Missing Heritability Problem.” Philosophy of Science.Google Scholar
Brandon, Robert N. 1990. Adaptation and Environment. Princeton, NJ: Princeton University Press.Google Scholar
Carroll, John W. 2009. “Anti-reductionism.” In The Oxford Handbook of Causation, ed. Menzies, Peter, Beebee, Helen, and Hitchcock, Christopher, 279–98. Oxford: Oxford University Press.Google Scholar
Dawkins, Richard. 1982. The Extended Phenotype: The Long Reach of the Gene. Oxford: Oxford University Press.Google Scholar
Downes, Stephen M. 2009. “Heritability.” In The Stanford Encyclopedia of Philosophy, ed. Zalta, Edward N.. Stanford, CA: Stanford University. http://plato.stanford.edu/archives/spr2014/entries/heredity/.Google Scholar
Driver, Julia. 2007. “Attributions of Causation and Moral Responsibility.” In Moral Psychology, Vol. 2, The Evolution of Morality, ed. Sinnott-Armstrong, Walter, 423–40. Cambridge, MA: MIT Press.Google Scholar
Eaves, Lindon J., Last, Krystyna, Martin, Nicholas G., and Jinks, John L.. 1977. “A Progressive Approach to Non-additivity and Genotype-Environmental Covariance in the Analysis of Human Differences.” British Journal of Mathematical and Statistical Psychology 30 (1): 1–42.CrossRefGoogle Scholar
Falconer, Douglas S., and MacKay, Trudy F.. 1996. Introduction to Quantitative Genetics. 4th ed. London: Pearson.Google Scholar
Feldman, Marcus W., and Lewontin, Richard C.. 1975. “The Heritability Hang-Up.” Science 190:1163–68.CrossRefGoogle ScholarPubMed
Fisher, Ronald A. 1918. “The Correlation between Relatives on the Supposition of Mendelian Inheritance.” Philosophical Transactions of the Royal Society of Edinburgh 52:399–433.CrossRefGoogle Scholar
Gibbard, Alan. 2001. “Genetic Plans, Genetic Differences, and Violence: Some Chief Possibilities.” In Genetics and Criminal Behaviour, ed. Wasserman, David and Wachbroit, Robert, 169–98. Cambridge: Cambridge University Press.Google Scholar
Griffiths, Paul E., and Neumann-Held, Eva M.. 1999. “The Many Faces of the Gene.” BioScience 49 (8): 656–62.CrossRefGoogle Scholar
Haig, David. 2012. “The Strategic Gene.” Biology and Philosophy 27 (4): 461–79.CrossRefGoogle Scholar
Jacquard, Albert. 1983. “Heritability: One Word, Three Concepts.” Biometrics 39:465–77.CrossRefGoogle ScholarPubMed
Jencks, Christopher. 1980. “Heredity, Environment and Social Policy Reconsidered.” American Sociological Review 45:723–36.CrossRefGoogle ScholarPubMed
Jencks, Christopher, Smith, Marshall, Acland, Henry, Bane, Mary Jo, Cohen, David, Gintis, Herbert, Heyns, Barbara, and Michelson, Stephen. 1972. Inequality: A Reassessment of the Effect of Family and Schooling in America. New York: Basic.Google Scholar
Jensen, Arthur R. 1976. “The Problem of Genotype-Environment Correlation in the Estimation of Heritability from Monozygotic and Dizygotic Twins.” Acta Geneticae Medicae et Gemellologiae 25:86–99.CrossRefGoogle ScholarPubMed
Jinks, John L., and Fulker, David W.. 1970. “Comparison of the Biometrical Genetical, MAVA, and Classical Approaches to the Analysis of Human Behavior.” Psychological Bulletin 73:311–49.CrossRefGoogle Scholar
Johannsen, Wilhelm. 2014. “The Genotype Conception of Heredity.” International Journal of Epidemiology 43 (4): 989–1000.CrossRefGoogle ScholarPubMed
Kaebnick, Gregory E. 2006. “Behavioral Genetics and Moral Responsibility.” In Wrestling with Behavioral Genetics: Science, Ethics, and Public Conversation, ed. Parens, Erik, Chapman, Audrey R., and Press, Nanacy, 220–24. Baltimore: Johns Hopkins University Press.Google Scholar
Layzer, David. 1974. “Heritability Analysis of IQ Scores: Science or Numerology.” Science 183:1259–66.CrossRefGoogle ScholarPubMed
Lerner, Richard M. 1995. “The Place of Learning within the Human Development System: A Developmental Contextual Perspective.” Human Development 38 (6): 361–66.CrossRefGoogle Scholar
Lewontin, Richard C. 1974. “Annotation: The Analysis of Variance and the Analysis of Causes.” American Journal of Human Genetics 26 (3): 400–411.Google ScholarPubMed
Lewontin, Richard C. 2011. “The Genotype/Phenotype Distinction.” In The Stanford Encyclopedia of Philosophy, ed. Zalta, Edward N.. Stanford, CA: Stanford University. http://plato.stanford.edu/archives/sum2011/entries/genotype-phenotype/.Google Scholar
Loehlin, John C., Lindzey, Gardner, and Spuhler, James N.. 1975. Race Differences in Intelligence. San Francisco: Freeman.Google Scholar
Lu, Qiaoying, and Bourrat, Pierrick. Forthcoming. “The Evolutionary Gene and the Extended Evolutionary Synthesis.” British Journal for the Philosophy of Science.Google Scholar
Lynch, Kate E. 2016. “Heritability and Causal Reasoning.” Biology and Philosophy. doi:10.1007/s10539-016-9535-1.CrossRefGoogle Scholar
Lynch, Kathleen E., and Kemp, Darrell J.. 2014. “Nature-via-Nurture and Unravelling Causality in Evolutionary Genetics.” Trends in Ecology and Evolution 29 (1): 2–4.CrossRefGoogle ScholarPubMed
Lynch, Michael, and Walsh, Bruce. 1998. Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer.Google Scholar
Meek, Shantel E., Lemery-Chalfant, Kathyrn, Jahromi, Laudan B., and Valiente, Carlos. 2013. “A Review of Gene-Environment Correlations and Their Implications for Autism: A Conceptual Model.” Psychological Review 120 (3): 497–521.CrossRefGoogle ScholarPubMed
Oftedal, Gry. 2005. “Heritability and Genetic Causation.” Philosophy of Science 72 (5): 699–709.CrossRefGoogle Scholar
Plomin, Robert, DeFries, John C., and Loehlin, John C.. 1977. “Genotype-Environment Interaction and Correlation in the Analysis of Human Behavior.” Psychological Bulletin 84:309–22.CrossRefGoogle ScholarPubMed
Plomin, Robert, DeFries, John C., McClearn, Gerald E., and McGuffin, Peter. 2008. Behavioral Genetics. 5th ed. New York: Worth.Google Scholar
Roberts, R. C. 1967. “Some Concepts and Methods in Quantitative Genetics.” In Behavior Genetics Analysis, ed. Hirsch, Jerry, 214–57. New York: McGraw Hill.Google Scholar
Rutter, Michael, Moffitt, Terrie E., and Caspi, Avshalom. 2006. “Gene-Environment Interplay and Psychopathology: Multiple Varieties but Real Effects.” Journal of Child Psychology and Psychiatry 47 (3–4): 226–61.CrossRefGoogle ScholarPubMed
Rutter, Michael, and Silberg, Judy. 2002. “Environment Interplay in Relation to Emotional and Behavioral Disturbance.” Annual Review of Psychology 53 (1): 463–90.CrossRefGoogle ScholarPubMed
Sesardic, Neven. 2005. Making Sense of Heritability. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Sober, Elliot. 2001. “Separating Nature and Nurture.” In Genetics and Criminal Behaviour, ed. Wasserman, David and Wachbroit, Robert, 47–78. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Tabery, James. 2014. Beyond Versus: The Struggle to Understand the Interaction of Nature and Nurture. Cambridge, MA: MIT Press.CrossRefGoogle Scholar
Turkheimer, Eric, and Waldron, Mary. 2000. “Nonshared Environment: A Theoretical, Methodological, and Quantitative Review.” Psychological Bulletin 126 (1): 78–108.CrossRefGoogle ScholarPubMed
Williams, George C. 1966. Adaptation and Natural Selection: A Critique of Some Current Evolutionary Thought. Princeton, NJ: Princeton University Press.Google Scholar
Woodward, James. 2003. Making Things Happen: A Theory of Causal Explanation. Oxford: Oxford University Press.Google Scholar