Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-17T18:07:37.565Z Has data issue: false hasContentIssue false
  • English
  • Français

Improvement of solubility and biocompatibility of MnO based nanoparticles in aqueous solutions

Published online by Cambridge University Press:  28 June 2011

Kerstin Koll ,
Thomas D. Schladt ,
Stefan Weber ,
Florian D. Jochum ,
Patrick Theato ,
Laura M. Schreiber  and
Wolfgang Tremel
Kerstin Koll
Affiliation:
Institut für anorganische und analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, 55099 Mainz, Germany
Thomas D. Schladt
Affiliation:
IBM Almaden Research Center, San Jose, CA 95120-6099 TN 37831-6376, U.S.A.
Stefan Weber
Affiliation:
Institut für medizinische Physik, Klinik und Polyklinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Mainz (Germany)
Florian D. Jochum
Affiliation:
Institut für organische Chemie, Johannes Gutenberg-Universität Mainz (Germany)
Patrick Theato
Affiliation:
Institut für organische Chemie, Johannes Gutenberg-Universität Mainz (Germany)
Laura M. Schreiber
Affiliation:
Institut für medizinische Physik, Klinik und Polyklinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Mainz (Germany)
Wolfgang Tremel
Affiliation:
Institut für anorganische und analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, 55099 Mainz, Germany
Get access

Abstract

MnO nanoparticles were surface modified using two different multifunctional polymers. By introducing a PEG group, the long term stability, MRI applicability and sterile filtration could be greatly improved. Furthermore, PEGylated MnO NPs were less toxic compared to non-PEGylated NPs. The results suggest that these nanoparticles are suitable for in vivo applications.

Keywords

nanostructureMnbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1346: Symposium AA – Micro- and Nanofluidic Systems for Materials Synthesis, Device Assembly and Bioanalysis , 2011 , mrss11-1346-aa10-01
Copyright
Copyright © Materials Research Society 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Schladt, T. D., Schneider, K., Schild, H. and Tremel, W., Dalton Trans., DOI: 10.1039/c0dt00689kGoogle Scholar
2. Yallapu, M. M., Foy, S.P., Jain, T.K. and Labhasetwar, V., Pharm. Res., 27, 2283 (2010)Google Scholar
3. Shukoor, I.M., Natalio, F., Tahir, M.N., Ksenofontov, V., Therese, H.A., Theatom, P., Schröder, H.C., Müller, W.E.G. and Tremel, W., Chem. Commun., 4677–4679 (2007)Google Scholar
4. Jun, Y-W, Lee, J-H and Cheon, J., Angew. Chem. Int. Ed. 41, 5112 (2008)Google Scholar
5. Na, H.B., Lee, J.H., An, K., Park, Y.I, Park, M., Lee, I.S., Nam, D.H., Kim, S.T., Kim, S.H., Kim, S.W., Lim, K.H., Kim, K.S., Kim, S.O. and Hyeon, T., Angew. Chem. Int. Ed., 46, 5397 (2007)Google Scholar
6. F-H., Chen, Zhang, L-M., Chen, Q-T., Zhang, Y. and Z-J., Zhang, Chem. Commun., 46, 8633 (2010)Google Scholar
7. Ahrén, M., Selegaed, L., Klasson, A., Söderlind, F., Abrikossova, N., Skolund, C., Bengtsson, T., Engström, M., Käll, P-O- and Uvdal, K., Langmuir, 26, 5753 (2010)Google Scholar
8. Schladt, T.D., Schneider, K., Shukoor, M.I., Natalio, F., Bauer, H., Tahir, M.N., Weber, S., Schreiber, L.M., Schröder, H.C., Müller, W.E.G. and Tremel, W., J. Mater. Chem., 20, 8297 (2010)Google Scholar
9. Petros, R.A. and DeSimone, J.M., Nature Reviews, 9, 615 (2010)Google Scholar
10. Duncan, R.. Nature Reviews, 6, 688 (2006)Google Scholar
11. Schladt, T.D., Graf, T., Tremel, W., Chem. Mater., 21, 3183 (2009)Google Scholar
12. Shukoor, M.I., Natalio, F., Ksenofontov, V., Tahir, M.N., Eberhardt, M., Theato, P., Schröder, H.C., Müller, W.E.G. and Tremel, W., Small, 3, 1374 (2007)Google Scholar
13. Schladt, T. D., Shukoor, M.I., Schneider, K., Tahir, M.N., Natalio, F., Ament, I., Becker, J., Jochum, F.D., Weber, S., Köhlerm, O., Theato, P., Schreiber, L.M., Sönnichsen, C., Schröder, H.C., Müller, W.E.G. and Tremel, W., Angew. Chem. Int. Ed., 49, 3976 (2010)Google Scholar