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Effect of denervation on primate laryngeal muscles: a morphologic and morphometric study

Published online by Cambridge University Press:  29 June 2007

V. Sahgal  and
M. H. Hast
V. Sahgal
Affiliation:
Chicago, U.S.A.
M. H. Hast*
Affiliation:
Chicago, U.S.A.
*
Prof. M. H. Hast, Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611.
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Abstract

Primate intrinsic laryngeal muscles studied consisted of Type I and Type II fibres. Type II fibres were larger than Type I fibres. The coefficient of variance of these muscles suggested that the fibre-size variation was similar in all of these muscles. Denervation resulted in shrinking of Type II fibres at two weeks in all the muscles, while at four weeks the thyroarytenoid showed an inflammatory reaction and far greater reduction in size than the other muscles. At eight weeks, however, all the muscles were fibrosed. We conclude that laryngeal muscles begin to show evidence of denervation at two weeks and are fibrosed in eight weeks. The thyroarytenoid muscle showed inflammatory degeneration, while the posterior cricoarytenoid and cricothyroid muscles showed classical changes of denervation. These findings should have clinical significance in the timing of reinnervation procedures.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 100 , Issue 5 , May 1986 , pp. 553 - 560
Copyright
Copyright © JLO (1984) Limited 1986

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