Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-18T07:41:17.940Z Has data issue: false hasContentIssue false
  • English
  • Français

Amylase activity in tracheobronchial secretions of laryngectomized patients

Published online by Cambridge University Press:  29 June 2007

V. Nandapalan ,
J. C. McIlwain  and
J. England
V. Nandapalan
Affiliation:
Department of Otorhinolaryngology, Royal Liverpool University Hospital, Prescot Street, Liverpool.
J. C. McIlwain*
Affiliation:
Department of Otorhinolaryngology, Liverpool and Whiston Hospital, Prescot Street, Liverpool.
J. England
Affiliation:
Department of Otorhinolaryngology, Liverpool and Whiston Hospital, Prescot Street, Liverpool.
*
Mr J. C. McIlwain Department of Otorhinolaryngology, Whiston Hospital, Prescot, Merseyside L35 5DR. Fax: 0151 430 1094
Get access Rights & Permissions [Opens in a new window]

Abstract

The alpha-amylase activity in tracheobronchial secretions of 16 consecutive patients with a total laryngectomy was studied. None of these patients had a tracheopharyngeal fistula or pulmonary disorder which might affect the amylase activity. This study proves the presence of amylase in tracheobronchial secretions of laryngectomized patients with a normal lung at a level between x and y and the quantitative analysis of the amylase activity is discussed. The relevance of investigating laryngectomy patients is because of the nature of the surgery the lower respiratory tract is permanently and physically isolated from any other source of salivary amylase. No similar study of the analysis of amylase in normal lung tissue had been reported before.

This information may be of value in order to detect salivary aspiration in patients with a tracheostomy or endotracheal intubation if the level in the aspirate is in the order of a-b times greater than that found in normal tracheobronchial secretions, (x = 35 and y = 1125 i.u./l; a = 31.8 and b = 628.6 i.u./l).

Keywords

AmylasesLaryngectomyTrachea, secretionsBronchus, secretions
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 7 , July 1995 , pp. 637 - 639
Copyright
Copyright © JLO (1984) Limited 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benjamin, D. R., Kenny, M. A. (1974) Clinical value of amylase isoenzyme determination. American Journal of Clinical Pathology 62: 752–758.CrossRefGoogle Scholar
Berk, J. E., Shimamura, J., Fridhandler, L. (1978) Amylase changes in disorders of the lung. Gastroenterology 74: 1313–1317.CrossRefGoogle ScholarPubMed
Clarke, P. D., Bain, B. C, Davies, A., Levin, G. E., Lambert, H. P. (1981) Aspiration in seriously ill patients; a study of amylase in bronchial secretions. Journal of Clinical Pathology 34: 803–805.CrossRefGoogle ScholarPubMed
Ende, N. (1960) Studies of amylase activity in pleural effusions and ascities. Cancer 13: 283–287.3.0.CO;2-2>CrossRefGoogle Scholar
Ende, N. (1961) Amylase activity in body fluids. Cancer 14: 1109–1114.3.0.CO;2-X>CrossRefGoogle Scholar
Ganong, W. F. (1987) Review of Medical Physiology, Ch. 25, 13th Edition, Appleton and Lange, USA, pp 391–394 and 406–407.Google Scholar
Harada, K., Kitamura, M. (1971) Amylase isoenzyme in a patient with primary bronchial carcinoma. Medicine and Biology 82: 155–158.Google Scholar
Heffernon, J. J., Smith, W. R., Fridhandler, L., Berk, J. E. (1976) Hyperamylasemia in heroin addicts; characterization by isoamylase analysis. American Journal of Gastroenterology 66: 17–22.Google ScholarPubMed
Luhr, H. (1951) Die Erhohung des glykolytischen Ferments Diatase in Serum bei Bronchial karzinom als Fruhsymptom. Munchener Medizinische Wochenschrift 93: 2407–2408.Google Scholar
McGeachin, R. L., Adams, M. R. (1957) Serum amylase and lung cancer. Cancer 10: 497–499.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Moores, W. Y., Gago, O., Morris, J. D., Peck, C. C. (1977) Serum and urinary amylase levels following pulsatile and continuous cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 74: 73–76.CrossRefGoogle ScholarPubMed
Otsuki, M., Maeda, M., Yuu, H., Yamasaki, J., Okano, K., Saeki, S., Sakamoto, C., Baba, S. (1977) The nature and origin of hyperamylasemia following open heart surgery with extracorporeal circulation. Clinica Chimca Ada 77: 349–357.Google ScholarPubMed
Sachar, L. A. (1952) Simplified laboratory test for acute pancreatitis. American Journal of Clinical Pathology 22: 1117–1125.CrossRefGoogle ScholarPubMed
Saugier, B., Emonot, M., Plauchu, M. (1976) Les epanchements riches en amylase en dehors des pancreatities Nouvelle Presse Medicate 5: 2777–2780.Google Scholar
Takano, T. (1938) Influence of organ extracts on the amylolytic action of blood taken from the right and left cardiac halves of rabbits. Journal of Oriental Medicine, (Abstract Section) 28: 98–99.Google Scholar
Weiss, M. J., Edmondson, H. A., Wertman, M. (1951) Elevated serum amylase associated with bronchogenic carcinoma. American Journal of Clinical Pathlogy 21: 1057–1061.CrossRefGoogle ScholarPubMed