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Larval toxocariasis and its clinical manifestation in childhood in the Slovak Republic

Published online by Cambridge University Press:  11 April 2024

J. Kinčeková ,
K. Reiterová  and
P. Dubinský
J. Kinčeková*
Affiliation:
Parasitological Institute of the Slovak Academy of Sciences, Hlinkova 3, 040 01 Kosice, Slovak Republic
K. Reiterová
Affiliation:
Parasitological Institute of the Slovak Academy of Sciences, Hlinkova 3, 040 01 Kosice, Slovak Republic
P. Dubinský
Affiliation:
Parasitological Institute of the Slovak Academy of Sciences, Hlinkova 3, 040 01 Kosice, Slovak Republic
*
*Fax: 421 95 63 31414 E-mail: pausav@saske.sk
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Abstract

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Results are presented of 90 children aged 1–15 years hospitalized with toxocariasis. Blood count analysis and laboratory examination were done by routine clinical laboratory methods. Anti-Toxocara antibodies were detected in the serum of patients using an ELISA method. Demographic analysis of the children's families exposed to the risk of disease allowed estimation of age-specific rates for clinical toxocariasis. The probability of toxocaral infection and the intensity of its clinical manifestations in children are determined by the epidemiology of this zoonosis and by the risk factors in the family. The presence of high titres of specific IgG antibodies in all age categories correlates with the clinical manifestations of toxocariasis. The highest admission rate is in the age categories of 3–5 years (43.3%) and 6–10 years (36.7%). Laboratory findings show that the most conspicuous changes occur in the age category 1–5 years. The high percentage of seropositive dog-keeping and puppy-breeding families and the possibility of infection with repeated doses of larvae stimulate eosinophilia, which prevails in children under the age of five years. We present the percentage of patients whose parameters showed deviations from the reference values for a particular age category. Analyses of laboratory indices and of clinical manifestations will contribute to the accuracy of diagnosis and effectiveness of treatment of this disease.

Type
Research Article
Information
Journal of Helminthology , Volume 73 , Issue 4 , April 1999 , pp. 323 - 328
Copyright
Copyright © Cambridge University Press 1999

References

Buijs, J., Borsboom, G., van Gemund, J.J., Hazebroek, A., van Dongen, P.A.M., van Knapen, F. & Nijkamp, H.J. (1994) Toxocara seroprevalence in 5-year-old elementary schoolchildren: relation with allergic asthma. American Journal of Epidemiology 140, 639–646.CrossRefGoogle ScholarPubMed
Edwards, M.G. & Pordell, G.R. (1985) Ocular toxocariasis studied by CT scanning. Radiology 157, 685–686.CrossRefGoogle ScholarPubMed
Ellis, G., Pakalnis, V.A., Worley, G., Gree, J.A., Frontingham, T.E., Sturner, R.A. & Walls, K.W. (1986) Toxocara canis infestation. Clinical and epidemiological associations with seropositivity in kindergarden children. Ophthalmology 93, 1032–1037.CrossRefGoogle Scholar
Ghafoor, S.Y., Smith, H.V., Lee, W.R., Quinn, R. & Girdwood, R.W. (1984) Experimental ocular toxocariasis: a mouse model. British Journal of Ophthalmology 68, 89–96.CrossRefGoogle ScholarPubMed
Gillespie, S.H., Dinnig, W.J., Voller, A. & Croucroft, N.S. (1993) The spectrum of ocular toxocariasis. Eye 7, 415–418.CrossRefGoogle ScholarPubMed
Glickman, L.T. & Schantz, P.M. (1981) Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiologic Reviews 3, 230–250.CrossRefGoogle ScholarPubMed
Ishibashi, H., Shimamura, R., Hirata, Y., Kudo, J. & Onizuka, H. (1992) Hepatic granuloma in toxocaral infection: role of ultrasonography in hypereosinophilia. Journal of Clinical Ultrasound 20, 204–210.CrossRefGoogle ScholarPubMed
Karalus, N.C., Garret, J.E. & Lang, S.D.R. (1995) Roxithromycin 150 mg t.i.d. versus amoxycillin 500 mg/ clavulanic acid 125 mg t.i.d. for the treatment of lower respiratory tract infections in general practice. Infection 23, 15–20.CrossRefGoogle ScholarPubMed
Kerr-Muir, M.G. (1994) Toxocara canis and human health. British Medical Journal 309, 5–6.CrossRefGoogle ScholarPubMed
Kimmig, P., Naser, K. & Frank, W. (1991) Seroepidemiologische Untersuchungen zur Toxocariasis des Menschen. Zentralblatt für Hygiene und Umweltmedizin 191, 406–422.Google Scholar
Kinceková, J., Suchá, E., Dubinský, P. & Szabadosová, V. (1996) Larval toxocarosis in childhood. Helminthologia 33, 187–193.Google Scholar
Le Luyer, B., Menager, V., Andebert, C. Le, Roux, P., Briguet, M.T. & Boulloche, J. (1990) Inflammatory joint disease as a manifestation of Toxocara canis larva migrans. Annales de Pediatrie 37, 445–448.Google ScholarPubMed
Linthoudt, van, D., Mean, A.P., Favre, R. & Ott, H. (1990) Arthritis of the hip associated with infantile toxocariasis. Schweizerische Rundschau für Medizin Praxis 79, 1022–1024.Google ScholarPubMed
Logar, J., Kraut, A. & Likar, M. (1993) Toxocara antibodies in patients with visceral and ocular disorder in Slovenia. Infection 21, 27–29.CrossRefGoogle ScholarPubMed
Mancal, P. (1987) Methods of enzyme immunoanalysis. 67 pp. Prague, Publ. House of USOL.Google Scholar
Notario, G., Siepman, N. & Devcich, K. (1994) Clarithromycin in the treatment of acute bacterial exacerbation of chronic bronchitis. 2nd International Conference on the Macrolides, Azalides and Treptogramins. Italy, 89.Google Scholar
Olson, L.J. (1976) Ocular toxocariasis in mice: distribution of larvae and lesions. International Journal for Parasitology 6, 247–251.CrossRefGoogle ScholarPubMed
Petithory, J.C., Chaumeil, C., Liotet, S., Rosseau, M. & Bisognani, A.C. (1993) Immunological studies on ocular larva migrans. pp. 81–91 in Lewis, J.W. & Maizels, R.M. (Eds) Toxocara and toxocariasis. London, Institute of Biology and the British Society for Parasitology.Google Scholar
Preiss, V. (1982) Die Toxocariasis im Kindesalter. Larva migrans visceralis-Syndrom. Monatschrift für Kinderheilkunde 130, 99–104.Google Scholar
Roig, J., Romen, J., Riera, C., Texido, A., Domingo, Ch. & Morera, J. (1992) Acute eosinophilic pneumonia due to toxocarosis with bronchoalveolar larvae findings. Chest 102, 294–296.CrossRefGoogle ScholarPubMed
Rüttinger, P. & Hadaidi, H. (1991) MRI in cerebral toxocaral disease. Journal of Neurology, Neurosurgery and Psychiatry 54, 361–362.CrossRefGoogle ScholarPubMed
Sakalova, A. Lipšic, T. (1995) Haematology and transfusiology. 253 pp. Martin, Osveta.Google Scholar
Savigny de, D.H. (1975) In vitro maintenance of Toxocara canis larvae and a simple method for the production of Toxocara ES antigen for use in serodiagnostic test for visceral larva migrans. Journal of Parasitology 61, 781–782.CrossRefGoogle Scholar
Schantz, P.M. (1989) Toxocara larva migrans now. American Journal of Tropical Medicine and Hygiene 41, 21–34.CrossRefGoogle ScholarPubMed
Schönherr, V. & Bialasiewicz, A.A. (1990) Subretinales granulom mit Verbalkung bei Toxocariasis. Klinische Monatsblatter für Augenheilkunde 197, 422–425.CrossRefGoogle ScholarPubMed
Taylor, M.R., Keane, C.T., O'Connor, P., Mulvihill, E. & Holland, C. (1988) The expanded spectrum of toxocaral disease. Lancet 1, 692–695.CrossRefGoogle ScholarPubMed
Végh, M. & Danka, J. (1987) Das Krankenheitsbild und die Behandlung der Toxocara canis-Uveitis im Kindersalter. Klinische Monatsblatter für Augenheilkunde 191, 395–396.Google Scholar
Vliegera, de, A., Druart, M. & Puttemans, M. (1992) Roxithromycin versus doxycycline in treatment of acute exacerbations of chronic bronchitis. Diagnostic Microbiology and Infectious Diseases 15, 123–127.CrossRefGoogle Scholar