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Efficacy of enterotoxigenic Escherichia coli vaccine for bovine clinical mastitis

Published online by Cambridge University Press:  04 March 2011

Kazuhide Morimoto ,
Madoka Shimizu ,
Tomoyasu Kurose ,
Keiji Nakatani ,
Shinji Akita ,
Yasunori Shinozuka  and
Naoki Isobe
Kazuhide Morimoto*
Affiliation:
Hiroshima Prefectural Technology Research Institute, Livestock Technology Research Center, 584 Nanatsuka-cho, Shobara, Hiroshima, 727-0023Japan
Madoka Shimizu
Affiliation:
Hiroshima Prefectural West Livestock Health & Hygiene Service Center, 1-15, Saijogojo-cho, Higashihiroshima, Hiroshima 739-0013Japan
Tomoyasu Kurose
Affiliation:
Higashihiroshima Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 284-1, Inaki, Takaya-cho, Higashihiroshima, Hiroshima, 739-2106Japan
Keiji Nakatani
Affiliation:
Hatsukaichi Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 10-14, Honmachi, Hatsukaichi, Hiroshima, 738-0015Japan
Shinji Akita
Affiliation:
Higashihiroshima Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 284-1, Inaki, Takaya-cho, Higashihiroshima, Hiroshima, 739-2106Japan
Yasunori Shinozuka
Affiliation:
Miyoshi Veterinary Clinical Center, Hiroshima P.F.A.M.A.A 3-6-36, Tokaichihigashi, Miyoshi, Hiroshima, 728-0013Japan
Naoki Isobe
Affiliation:
Graduate School of Biosphere Science, Hiroshima University1-4-4, Kagamiyama, Higashihiroshima, Hiroshima, 739-8528Japan
*
*For correspondence: khd02062@nifty.com
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Abstract

An enterotoxigenic Escherichia coli (ETEC) vaccine designed to prevent diarrhoea was inoculated into dairy cows, and the occurrence of clinical mastitis was investigated for 2 years. Half of 480 cows in five farms were subcutaneously inoculated with ETEC vaccine (Imocolibov) twice with a 1-month interval in 2007 and 2008. Fisher's exact test and survival (time to event) analysis with the log-rank test were used to compare vaccinates and controls. In 2007, there was no significant difference in the incidence rate of mastitis between vaccinate (20·3%) and control (17·1%) cows. The rate of death or culling due to mastitis was lower in vaccinated cows (7·4%) than in control cows (29·2%, P=0·07, Fisher's exact test; P=0·02, log-rank test). In 2008, there was no significant difference in both the incidence rate of mastitis and the rate of death or culling due to mastitis. Milk productivity was compared between vaccinates and controls in one farm. Multi-way analysis of variance (ANOVA) was performed for the amount of 4% fat-corrected milk, and there was no significant difference between vaccinates and controls. These results suggest that ETEC vaccine inoculation reduces death or culling due to mastitis, whereas no preventive effect on the development of mastitis was observed.

Keywords

Vaccinebovine mastitisETECefficacy
Type
Research Article
Information
Journal of Dairy Research , Volume 78 , Issue 2 , May 2011 , pp. 149 - 153
Copyright
Copyright © Proprietors of Journal of Dairy Research 2011

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