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Co-existence of diabetes and TB among adults in India: a study based on National Family Health Survey data

Published online by Cambridge University Press:  22 September 2020

Apyayee Sil Open the ORCID record for Apyayee Sil [Opens in a new window] ,
Dinabandhu Patra ,
Preeti Dhillon Open the ORCID record for Preeti Dhillon [Opens in a new window]  and
Padmanesan Narasimhan
Apyayee Sil
Affiliation:
Department of Mathematical Demography and Statistics, International Institute for Population Sciences, Mumbai, India
Dinabandhu Patra
Affiliation:
Department of Mathematical Demography and Statistics, International Institute for Population Sciences, Mumbai, India
Preeti Dhillon*
Affiliation:
Department of Mathematical Demography and Statistics, International Institute for Population Sciences, Mumbai, India
Padmanesan Narasimhan
Affiliation:
School of Public Health & Community Medicine, UNSW Medicine, Sydney, NSW, Australia
*
*Corresponding author. Email: pdhillon.iips@gmail.com
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Abstract

Multiple studies suggest that diabetes mellitus (DM) is a potential risk factor for tuberculosis (TB) development and treatment, especially in low- and middle-income countries. The study aimed to test concomitancy between DM and TB among adults in India. Data were from the 2015–16 National Family Health Survey (NFHS-4). The study sample comprised 107,575 men aged 15–54 and 677,292 women aged 15–49 for which data on DM status were available in the survey. The association between state-level prevalence of TB and DM was examined and robust Poisson regression analysis applied to examine the effect of DM on TB. A high prevalence of TB was observed among individuals with diabetes in India in 2015–16. A total of 866 per 100,000 men and 405 per 100,000 women who self-reported having diabetes also had TB; among those who self-reported not having diabetes the ratios were 407 per 100,000 men and 241 per 100,000 women. The risk of having TB among those who self-reported having DM was higher for both men (2.03, 95% CI: 1.26, 3.28) and women (1.79, 95% CI: 1.48, 2.49) than for those who did not self-report having DM. Adults who were diagnosed with diabetes (including pre-diabetes) also had a higher rate of TB (477 per 100,000 men and 331 per 100,000 women) than those who were not diagnosed (410 per 100,000 men and 239 per 100,000 women). Adults from poor families, with lower BMIs, lower levels of literacy and who were not working had a higher risk of TB–DM co-morbidity. The state-level pattern of co-morbidity, the under-reporting of DM (undiagnosed) and TB stigmatization are discussed. The study confirms that diabetes is an important co-morbid feature with TB in India, and reinforces the need to raise awareness on screening for the co-existence of DM and TB with integrated health programmes for the two conditions.

Keywords

TuberculosisDiabetesCo-morbidity
Type
Research Article
Information
Journal of Biosocial Science , Volume 53 , Issue 5 , September 2021 , pp. 758 - 772
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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