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Interaction of Hairless, Delta, Enhancer of split and Notch genes of Drosophila melanogaster as expressed in adult morphology

Published online by Cambridge University Press:  14 April 2009

Mariitta Siren  and
Petter Portin
Mariitta Siren
Affiliation:
Laboratory of Genetics, Department of Biology, University of Turku, SF-20500 Turku 50, Finland
Petter Portin*
Affiliation:
Laboratory of Genetics, Department of Biology, University of Turku, SF-20500 Turku 50, Finland
*
* Corresponding author.
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Summary

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The interaction of three neurogenic loci viz. Delta, Enhancer of split and Notch, and a related gene, Hairless, of Drosophila melanogaster was investigated at the adult morphology level by measuring the effects of the mutations of the three other genes on the expression of the recessive lethal antimorphic Abruptex mutations of the Notch locus. The Abruptex mutations were also coupled in cis or trans with facet-glossy or split mutations of the Notch locus. In some of the experiments, the genotype of the fly was homozygous for either facet-glossy or split mutation or their wild type alleles but heterozygous for the Abruptex. Facet-glossy is located in a large intron of the locus, whereas split is located in the same exon as Abruptex. In all compounds studied, Delta suppressed the expression of Abruptex while Hairless and Enhancer of split enhanced it. The interactions of the four genes studied were allele specific, suggesting an interaction at the protein level. The comparison of the results presented in this study on the interaction of the neurogenic genes with other results on the same subject suggests that the interactions are similar in embryonic and imaginal development.

Type
Research Article
Information
Genetics Research , Volume 54 , Issue 1 , August 1989 , pp. 23 - 26
Copyright
Copyright © Cambridge University Press 1989

References

Artavanis-Tsakonas, S., Grimwade, B. G., Harrison, R. G., Markopoulou, K., Muskavitch, M. A. T., Schlesinger-Bryant, R., Wharton, K. & Yedvobnick, B. (1984). The Notch locus of Drosophila melanogaster: A molecular analysis. Developmental Genetics 4, 233–254.CrossRefGoogle Scholar
de la Concha, A., Dietrich, U., Weigel, D. & Campos-Ortega, J. A. (1988). Functional interactions of neurogenic genes of Drosophila melanogaster. Genetics 118, 499–508.CrossRefGoogle ScholarPubMed
Hartley, D. A., Xu, T. & Artavanis-Tsakonas, S. (1987). The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the putative protein. The EM BO Journal 6, 3407–3418.Google Scholar
Kelley, M. R., Kidd, S., Deutsch, W. A. & Young, M. W. (1987). Mutations altering the structure of Epidermal Growth Factor-like coding sequences at the Drosophila Notch locus. Cell 51, 539–548.Google Scholar
Kidd, S., Lockett, T. & Young, M. W. (1983). The Notch locus of Drosophila melanogaster. Cell 34, 421–433.CrossRefGoogle ScholarPubMed
Kidd, S., Kelley, M. R. & Young, M. W. (1986). Sequence of the Notch locus of Drosophila melanogaster: Relationship of the encoded protein to mammalian clotting and growth factors. Molecular and Cellular Biology 6, 3094–3108.Google Scholar
Kidd, S. & Young, M. W. (1986). Transposon-dependent mutant phenotypes at the Notch locus of Drosophila. Nature 232, 89–91.Google Scholar
Knust, E., Bremer, K. A., Vässin, H., Ziemer, A., Tepan, U. & Campos-Ortega, J. A. (1987). The Enhancer of split locus and neurogenesis in Drosophila melanogaster. Developmental Biology 122, 262–273.CrossRefGoogle ScholarPubMed
Lehmann, R., Dietrich, U., Jimenez, F. & Campos-Ortega, J. A. (1981). Mutations of early neurogenesis in Drosophila. Wilhelm Roux's Archives of Developmental Biology 190, 226–229.CrossRefGoogle Scholar
Lehmann, R., Jimenez, F., Dietrich, U. & Campos-Ortega, J. A. (1983). On the phenotype of development of mutants of early neurogenesis in Drosophila melanogaster. Roux's Archives of Developmental Biology 192, 62–74.CrossRefGoogle Scholar
Lindsley, D. L. & Grell, E. H. (1986). Genetic Variations of Drosophila melanogaster. Washington: Carnegie Institute Publications.Google Scholar
Portin, P. (1981). The antimorphic mode of action of lethal Abruptex alleles of the Notch locus in Drosophila melanogaster. Hereditas 95, 247–251.CrossRefGoogle Scholar
Poulson, D. F. (1937). Chromosomal deficiencies and embryonic development of Drosophila melanogaster. Proceedings of The National Academy of Sciences of U.S.A. 23, 133–137.Google Scholar
Poulson, D. F. (1941). The developmental effects of a series of Notch deficiencies in the X-chromosome of Drosophila melanogaster. Proceedings of the 7th International Congress of Genetics, 240–241.Google Scholar
Technau, G. M. & Campos-Ortega, J. A. (1987). Cell autonomy of expression of neurogenic genes of Drosophila melanogaster. Proceedings of The National Academy of Sciences of U.S.A. 84, 4500–4504.CrossRefGoogle ScholarPubMed
Vässin, H., Bremer, K. A., Knust, E. & Campos-Ortega, J. A. (1987). The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EM BO Journal 6, 3431–3440.Google ScholarPubMed
Vässin, H., Vielmetter, J. & Campos-Ortega, J. A. (1985). Genetic interactions in early neurogenesis of Drosophila melanogaster. Journal of Neurogenetics 2, 291–308.CrossRefGoogle ScholarPubMed
Welshons, W. J. (1965). Analysis of a gene in Drosophila. Science 150, 1122–1129.Google Scholar
Wharton, K. A., Johansen, K. M., Xu, T. & Artavanis-Tsakonas, S. (1985). Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43, 567–581.Google Scholar