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Role of chemokines in proteinuric kidney disorders

Published online by Cambridge University Press:  17 February 2014

Juan Antonio Moreno*
Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain
Sara Moreno
Affiliation:
Department of Biotechnology, INIA, Madrid, Spain
Alfonso Rubio-Navarro
Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain
Carmen Gómez-Guerrero
Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
Alberto Ortiz
Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Fundacion Renal Iñigo Alvarez de Toledo/Instituto Reina Sofia de Investigacion Nefrologica (FRIAT/IRSIN), Spain
Jesús Egido
Affiliation:
Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain Fundacion Renal Iñigo Alvarez de Toledo/Instituto Reina Sofia de Investigacion Nefrologica (FRIAT/IRSIN), Spain Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain
*
*Corresponding author: Juan Antonio Moreno, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, 28040 Madrid, Spain. E-mail: jamoreno@fjd.es

Abstract

Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent progress in cellular and molecular understanding of the role of chemokines in the pathogenesis of proteinuria-induced renal injury, as well as their clinical implications and therapeutic potential.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2014 

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References

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Further reading, resources and contacts

Nephrology Dialysis Transplantation-Educational for kidney and blood pressure related disorders

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http://www.cybernephrology.org/

International Society of Nephrology

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American Society of Nephrology

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