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The influence of unheated guinea-pig serum on the neutralization of Semliki Forest virus by various antisera

Published online by Cambridge University Press:  15 May 2009

P. M. Osterrieth
P. M. Osterrieth
Affiliation:
Laboratoires de Microbiologic Générate et Médicate, Université de Liège
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The neutralization of a constant dose of Semliki Forest virus by various doses of different antisera was studied. The presence of complement (1/200, v/v) in the neutralization mixture inhibited the neutralization by high concentration of antiserum and somewhat potentiated neutralization by low serum concentration. Because the experiments were biased towards a measure of irreversible neutralization, the inhibition observed in the presence of complement appeared to be an inhibition of irreversible neutralization. This inhibition was interpreted as a dissociation of a complement binding virus–antibody complex. The antibodies involved appeared to be virus-specific.

Type
Research Article
Information
Journal of Hygiene , Volume 64 , Issue 1 , March 1966 , pp. 33 - 44
Copyright
Copyright © Cambridge University Press 1966

References

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