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Effect of intraoperative theophylline use on acute kidney injury in paediatric cardiac surgery

Part of: Surgery

Published online by Cambridge University Press:  02 February 2022

Yasemin Yavuz Open the ORCID record for Yasemin Yavuz [Opens in a new window]  and
Fatma Ukil Isildak
Yasemin Yavuz*
Affiliation:
Department of Anesthesia and Reanimation, Istanbul Kartal Kosuyolu High Speciality Educational and Research Hospital, Istanbul, Turkey
Fatma Ukil Isildak
Affiliation:
Department of Anesthesia and Reanimation, Istanbul Kartal Kosuyolu High Speciality Educational and Research Hospital, Istanbul, Turkey
*
Author for correspondence: Y. Yavuz, MD, Istanbul Kartal Kosuyolu High Speciality Educational and Research Hospital, Denizer Cd, Cevizli Kavsagi, 34865 Kartal, Istanbul, Turkey. Tel: +905324880172; Fax: +902164596321. E-mail: yavuzyase@gmail.com
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Abstract

Background:

This study aimed to examine the effects of theophylline use in preventing renal dysfunction in patients undergoing CHD surgery.

Methods:

A total of 94 patients aged 1–60 months were included in the study. Patients in the theophylline group were enrolled according to a pre-defined protocol for treatment administration, while controls were selected retrospectively from patients without theophylline treatment during the same period – who were matched according to critical baseline characteristics.

Results:

The incidence of acute kidney injury was similar between the two groups (p = 1.000). Higher urinary output and lower fluid balance were found intraoperatively and also postoperatively in the theophylline group (all, p < 0.050). Postoperative decrease in urinary output and estimated glomerular filtration rate were higher in the theophylline group (p < 0.050). Lower postoperative urea and creatinine levels were shown in theophylline recipients (p < 0.050). Urea levels increased significantly in the non-theophylline group during surgery (p < 0.001), and no significant change was observed in theophylline group (p = 0.136). Postoperative increase in creatinine and lactate levels was demonstrated in theophylline group (p < 0.050), and lactate levels were higher in the non-theophylline group during and after cardiopulmonary bypass (p = 0.010). Multiple linear regression analysis revealed less reduction in estimated glomerular filtration rate with higher age and in the presence of theophylline use (p < 0.050).

Conclusion:

Although we demonstrated a similar incidence of acute kidney injury in the both groups, we revealed an important decrease in serum creatinine, urea and lactate levels, accompanied by improved estimated glomerular filtration rate, increased urine output and decreased fluid overload, with theophylline treatment, suggesting that renal functions significantly improved with the use of theophylline.

Keywords

Congenital heart diseasetheophyllineacute kidney injurycardiopulmonary bypassNIRS
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 1 , January 2023 , pp. 60 - 68
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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