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RETRACTED - Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study

Published online by Cambridge University Press:  02 January 2018

Shinichiro Takiguchi ,
Takashi X. Fujisawa ,
Sakae Mizushima ,
Daisuke N. Saito ,
Yuko Okamoto ,
Koji Shimada ,
Michiko Koizumi ,
Hirokazu Kumazaki ,
Minyoung Jung  and
Hirotaka Kosaka
...Show all authors
Shinichiro Takiguchi
Affiliation:
Advanced Biomedical Sciences Course, Graduate School of Medical Sciences, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan
Takashi X. Fujisawa
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan
Sakae Mizushima
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan
Daisuke N. Saito
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Research Center for Child Mental Development, University of Fukui, and Biomedical Imaging Research Center, University of Fukui, Fukui, Japan
Yuko Okamoto
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Fukui, Research Center for Child Mental Development, University of Fukui, Fukui
Koji Shimada
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Research Center for Child Mental Development, University of Fukui, and Biomedical Imaging Research Center, University of Fukui, Fukui, Japan
Michiko Koizumi
Affiliation:
Research Center for Child Mental Development, University of Fukui, Fukui, Japan
Hirokazu Kumazaki
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan
Minyoung Jung
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui, Japan
Hirotaka Kosaka
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, University of Fukui, Research Center for Child Mental Development, University of Fukui, and Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Michio Hiratani
Affiliation:
Research Center for Child Mental Development, University of Fukui, Hiratani Clinic for Developmental Disorders of Children, Fukui, Japan
Yusei Ohshima
Affiliation:
Research Center for Child Mental Development, and Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Martin H. Teicher
Affiliation:
Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, Massachusetts, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Akemi Tomoda*
Affiliation:
Division of Developmental Higher Brain Functions, United Graduate School of Child Development, and Research Center for Child Mental Development, University of Fukui, Fukui
*
Akemi Tomoda, Research Center for Child Mental Development, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Fukui 910-1193, Japan. Email: atomoda@u-fukui.ac.jp
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Abstract

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Background

Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD).

Aims

To examine whether neural activity during reward processing was altered in children and adolescents with RAD.

Method

Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging.

Results

Significantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups.

Conclusions

Striatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology.

Type
Research Article
Information
BJPsych Open , Volume 1 , Issue 2 , October 2015 , pp. 121 - 128
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Copyright
Copyright © The Royal College of Psychiatrists 2015

Footnotes

Declaration of interest

None.

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