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An exploration of testosterone levels in patients with bipolar disorder

Published online by Cambridge University Press:  02 January 2018

Sarah C. Wooderson ,
Peter Gallagher ,
Stuart Watson  and
Allan H. Young
Sarah C. Wooderson
Affiliation:
Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, UK
Peter Gallagher
Affiliation:
Institute of Neuroscience (Academic Psychiatry), Newcastle University, Newcastle, UK
Stuart Watson
Affiliation:
Institute of Neuroscience, Newcastle University, Newcastle, UK
Allan H. Young*
Affiliation:
Centre for Affective Disorders, IoPPN, King's College London, UK
*
Allan H. Young, Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, PO72 De Crespigny Park, London SE5 8AF, UK. Email: allan.young@kcl.ac.uk
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Abstract

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Background

Testosterone influences well-being, mood and cognition and may play a role in the pathophysiology of bipolar disorder.

Aim

To examine testosterone levels in patients with bipolar disorder compared with healthy controls.

Method

We examined baseline total testosterone levels and current depression scores in male and female patients with bipolar disorder and mild to moderate depression and healthy controls.

Results

A significant interaction between diagnosis and gender was observed (F(2,97)=9.791, P=0.002). Testosterone levels were significantly lower for male patients with bipolar disorder compared with male controls (P=0.001). Women with bipolar disorder had significantly higher testosterone levels than female controls (P=0.03).

Conclusions

Disturbances in testosterone levels may represent an important neurobiological abnormality in bipolar disorder and may differ by gender. If these findings are confirmed, the use of gender appropriate treatment strategies for the normalisation of testosterone levels in bipolar disorder depression should be further explored.

Type
Research Article
Information
BJPsych Open , Volume 1 , Issue 2 , October 2015 , pp. 136 - 138
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Copyright
Copyright © The Royal College of Psychiatrists 2015

Footnotes

Declaration of interest

None.

References

1 Novick, DM, Swartz, HA, Frank, E. Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord 2010; 12: 1–9.CrossRefGoogle ScholarPubMed
2 Sylvia, LG, Thase, ME, Reilly-Harrington, NA, Salcedo, S, Brody, B, Kinrys, G, et al. Psychotherapy use in bipolar disorder: association with functioning and illness severity. Aust NZ J Psychiatry 2015; 49: 453–61.CrossRefGoogle ScholarPubMed
3 Sher, L, Grunebaum, MF, Sullivan, GM, Burke, AK, Cooper, TB, Mann, JJ, et al. Association of testosterone levels and future suicide attempts in females with bipolar disorder. J Affect Disord 2014; 166: 98–102.CrossRefGoogle ScholarPubMed
4 Weiner, CL, Primeau, M, Ehrmann, DA. Androgens and mood dysfunction in women: comparison of women with polycystic ovarian syndrome to healthy controls. Psychosom Med 2004; 66: 356–62.Google ScholarPubMed
5 Amanatkar, HR, Chibnall, JT, Seo, BW, Manepalli, JN, Grossberg, GT. Impact of exogenous testosterone on mood: a systematic review and meta-analysis of randomized placebo-controlled trials. Ann Clin Psychiatry 2014; 26: 19–32.Google Scholar
6 Burd, ID, Bachmann, GA. Androgen replacement in menopause. Curr Womens Health Rep 2001; 1: 202–5.Google ScholarPubMed
7 Crammer, JL. Premenstrual depression, cortisol and oestradiol treatment. Psychol Med 1986; 16: 451–5.CrossRefGoogle ScholarPubMed
8 Studd, J. Hormone therapy for reproductive depression in women. Post Reprod Health 2014; 20: 132–7.CrossRefGoogle ScholarPubMed
9 Johnson, JM, Nachtigall, LB, Stern, TA. The effect of testosterone levels on mood in men: a review. Psychosomatics 2013; 54: 509–14.CrossRefGoogle ScholarPubMed
10 Freinhar, JP, Alvarez, W. Androgen-induced hypomania. J Clin Psychiatry 1985; 46: 354–5.Google ScholarPubMed
11 First, MB, Spitzer, RL, Gibbon, M, Williams, JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version. Biometrics Research, 1997.Google Scholar
12 Watson, S, Gallagher, P, Porter, RJ, Smith, MS, Herron, LJ, Bulmer, S, et al. A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depression. Biol Psychiatry 2012; 72: 943–9.CrossRefGoogle ScholarPubMed
13 Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56–62.CrossRefGoogle ScholarPubMed
14 Montgomery, SA, Åsberg, M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382–9.CrossRefGoogle ScholarPubMed
15 Beck, AT, Ward, CH, Mendelson, M, Mock, J, Erbaugh, J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561–71.CrossRefGoogle ScholarPubMed
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