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Regional differences in dendritic spine density confer resilience to chronic social defeat stress

Published online by Cambridge University Press:  01 June 2017

Youge Qu ,
Chun Yang ,
Qian Ren ,
Min Ma ,
Chao Dong  and
Kenji Hashimoto
Youge Qu
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Chun Yang
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Qian Ren
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Min Ma
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Chao Dong
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Kenji Hashimoto*
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
*
Kenji Hashimoto, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan Tel: +81 43 226 2517; Fax: +81 43 226 2561; E-mail: hashimoto@faculty.chiba-u.jp
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Abstract

Objective

Although alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS).

Methods

We examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS.

Results

Spine density in the prelimbic area of mPFC, CA3, and DG in the susceptible group, but not resilient group, was significantly lower than control group. In contrast, spine density in the NAc and VTA in the susceptible group, but not resilient group, was significantly higher than control group.

Conclusions

The results suggest that regional differences in spine density may contribute to resilience versus susceptibility in mice subjected to CSDS.

Keywords

depressionresiliencestresssusceptible
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 30 , Issue 2 , April 2018 , pp. 117 - 122
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Copyright
© Scandinavian College of Neuropsychopharmacology 2017 

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