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9 - Evaluation and management of cardiovascular diseases in Down syndrome

Published online by Cambridge University Press:  05 July 2011

By
Guy Dembour  and
Stephane Moniotte
Edited by
Jean-Adolphe Rondal ,
Juan Perera  and
Donna Spiker
Guy Dembour
Affiliation:
Catholic University of Louvain
Stephane Moniotte
Affiliation:
Catholic University of Louvain
Jean-Adolphe Rondal
Affiliation:
Université de Liège, Belgium
Juan Perera
Affiliation:
Universitat de les Illes Balears, Palma de Mallorca
Donna Spiker
Affiliation:
Stanford Research Institute International
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Summary

Introduction

Down syndrome (DS) is the most common chromosomal anomaly. Its overall worldwide prevalence is approximately 10 per 10,000 live births, a number which tended to increase over the recent years. The increasing average maternal age at childbirth mostly explains the elevated prevalence of the syndrome. In the Netherlands, the prevalence of DS was estimated to be 16 per 10,000 live births in 2003 (Weijerman et al., 2008). Similarly, DS accounts for up to 8% of all registered cases of congenital anomalies in Europe (De Walle & Cornel, 1995).

Historically, the association between DS and congenital heart disease (CHD) was described very early on. Down, in his original description of 1866, mentioned the possibility of cardiac disease and reported that “the circulation is feeble.”

In 1894, Garrod reported the association between DS and CHD. In the early twentieth century, the presence of CHD was used as a feature to distinguish DS from cretinism. The specific association between DS and atrioventricular septal defect (AVSD) was reported by Ablert in 1924 and more accurately by Helen Taussig in 1947. The incidence of CHD in DS was first described with very wide variations, from 16% to 62% (Berg et al., 1960). The current observations demonstrate that infants with DS have a 40%–50% risk of CHD (Wells et al., 1994; Marino, 1996; Stoll et al., 1998; Freeman et al., 2008; Weijerman et al., 2008).

Type
Chapter
Information
Neurocognitive Rehabilitation of Down Syndrome
Early Years
 , pp. 128 - 141
Publisher: Cambridge University Press
Print publication year: 2011

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References

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