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PART V - INCREASING RESOLVING POWER

Published online by Cambridge University Press:  07 August 2009

Raphael Falk
Affiliation:
Hebrew University of Jerusalem
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Summary

Continuity between the early reductionist ethos and the late anti-vitalist sentiment of Francis Crick, Jacques Monod and Linus Pauling … is suggested in the areas of fine structural genetic analysis, as in Benzer's wish to “translate linkage distances, as derived from genetic recombination experiments into molecular units”; the development of the operon theory … and the genetic code, as in Crick's legislative codification of molecular biological reductionism in the Sequence Hypothesis and the Central Dogma.

Fuerst (1982, 268)

Toward the 1940s genetics became a self-confident autonomous discipline. The Nobel Prize awarded to Morgan in 1933 was a symbol of this autonomy and it certainly also added to its self-confidence.

During the first decades of the twentieth century, the methodology of hybridization analysis of discrete traits was established, and a conceptual framework for the mechanics of inheritance was formulated: genes were inherited entities that (within given environmental circumstances) determined the properties of morphological, physiological, as well as behavioral traits of living organisms; the chromosomal theory of inheritance situated the genes along the chromosomes and mapped them; the analysis of mutations combined with cytogenetic observations indicated that there was a material basis for the Mendelian Faktoren and demonstrated the mechanics of their inheritance. Geneticists in Morgan's group and elsewhere now invaded other disciplines and explored them more aggressively: Dobzhansky's Genetics and the Origin of Species (Dobzhansky, 1937) declared his intent to expand into the sphere of evolutionary research.

Type
Chapter
Information
Genetic Analysis
A History of Genetic Thinking
, pp. 171 - 177
Publisher: Cambridge University Press
Print publication year: 2009

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