Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-12-09T05:30:21.875Z Has data issue: false hasContentIssue false

10 - Medication Overuse Headache in the Emergency Department

Published online by Cambridge University Press:  09 October 2017

Serena L. Orr
Affiliation:
Children’s Hospital of Eastern Ontario, Ottawa
Benjamin W. Friedman
Affiliation:
Albert Einstein College of Medicine, New York
David W. Dodick
Affiliation:
Mayo Clinic, Phoenix, AZ
Get access

Summary

Abstract

Medication overuse headache (MOH) is defined as headache occurring on 15 or more days per month developing as a consequence of regular overuse of acute or symptomatic headache medication (on 10 or more, or 15 or more days per month, depending on the medication) for more than three months. Triptans, NSAIDs, acetaminophen, ergotamine, barbiturates, and opioids can all cause MOH. Although the optimal treatment strategy for MOH is debated, treatments include discontinuing the overused medications and treating with preventive migraine medications. In the ED, it is important to recognize patients who have MOH to provide appropriate treatment recommendations for MOH and to avoid perpetuating the patient’s medication overuse. In general, ED treatment of the patient with frequent headaches should not include narcotics or butalbital-containing medications as they are associated with the highest risk of developing MOH as well as the potential to create drug-seeking behavior. Proper follow-up should be arranged prior to discharge from the ED.

Type
Chapter
Information
Emergency Headache
Diagnosis and Management
, pp. 99 - 109
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders, 2nd edition. Cephalalgia. 2004;24(Suppl. 1):9160.Google Scholar
2.Silberstein, S, Olesen, J, Bousser, M-G, et al. The International Classification of Headache Disorders, 2nd edition (ICHD-II): revision of criteria for 8.2 medication-overuse headache. Cephalalgia. 2005;25(6):460–5.CrossRefGoogle ScholarPubMed
3.Headache Classification Committee, Olesen, J, Bousser, M-G, et al. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia. 2006;26(6):742–6.Google Scholar
4.Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629808.Google Scholar
5.Chiang, CC, Schwedt, TJ, Wang, SJ, Dodick, DW. Treatment of medication-overuse headache: a systematic review. Cephalalgia. 2016;36(4):371–86.Google Scholar
6.Wang, SJ, Fuh, JL. Medication overuse headache in Taiwan. Cephalalgia. 2008;28(11):1240–2.Google Scholar
7.Katsarava, Z, Diener, HC. Medication overuse headache in Germany. Cephalalgia. 2008;28(11):1221–2.Google Scholar
8.Becker, WJ, Purdy, RA. Medication overuse headache in Canada. Cephalalgia. 2008;28(11):1218–20.Google Scholar
9.Pascual, J, Mateos, V, Gracia, M, Láinez, JM. Medication overuse headache in Spain. Cephalalgia. 2008;28(11):1234–6.CrossRefGoogle ScholarPubMed
10.Ravishankar, K. Medication overuse headache in India. Cephalalgia. 2008;28(11):1223–6.Google Scholar
11.Jensen, R, Bendtsen, L. Medication overuse headache in Scandinavia. Cephalalgia. 2008;28(11):1237–9.Google Scholar
12.Kanki, R, Nagaseki, Y, Sakai, F. Medication-overuse headache in Japan. Cephalalgia. 2008;28(11):1227–8.CrossRefGoogle ScholarPubMed
13.Castillo, J, Muñoz, P, Guitera, V, Pascual, J. Epidemiology of chronic daily headache in the general population. Headache. 1999;39(3):190–6.Google Scholar
14.Scher, AI, Stewart, WF, Liberman, J, Lipton, RB. Prevalence of frequent headache in a population sample. Headache. 1998;38(7):497506.Google Scholar
15.Green, AL, Gu, P, De Felice, M, et al. Increased susceptibility to cortical spreading depression in an animal model of medication-overuse headache. Cephalalgia. 2014;34(8):594604.Google Scholar
16.Meng, ID, Dodick, D, Ossipov, MH, Porreca, F. Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies. Cephalalgia. 2011;31(7): 851–60.Google Scholar
17.Le Bars, D, Dickenson, AH, Besson, JM. Diffuse noxious inhibitory controls (DNIC): I. Effects on dorsal horn convergent neurones in the rat. Pain. 1979;6(3):283304.CrossRefGoogle ScholarPubMed
18.Okada-Ogawa, A, Porreca, F, Meng, ID. Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons. J Neurosci. 2009;29(50):15828–35.Google Scholar
19.Munksgaard, SB, Bendtsen, L, Jensen, RH. Modulation of central sensitisation by detoxification in MOH: results of a 12-month detoxification study. Cephalalgia. 2013;33(7):444–53.Google Scholar
20.Grazzi, L, Chiapparini, L, Ferraro, S, et al. Chronic migraine with medication overuse pre–post withdrawal of symptomatic medication: clinical results and FMRI correlations. Headache. 2010;50(6):9981004.Google Scholar
21.Bigal, ME, Lipton, RB. Excessive acute migraine medication use and migraine progression. Neurology. 2008;71(22):1821–8.CrossRefGoogle ScholarPubMed
22.Meskunas, CA, Tepper, SJ, Rapoport, AM, Sheftell, FD, Bigal, ME. Medications associated with probable medication overuse headache reported in a tertiary care headache center over a 15-year period. Headache. 2006;46(5):766–72.Google Scholar
23.Jensen, R, Zeeberg, P, Dehlendorff, C, Olesen, J. Predictors of outcome of the treatment programme in a multidisciplinary headache centre. Cephalalgia. 2010;30(10):1214–24.Google Scholar
24.Relja, G, Granato, A, Bratina, A, Antonello, RM, Zorzon, M. Outcome of medication overuse headache after abrupt in-patient withdrawal. Cephalalgia. 2006;26(5):589–95.Google Scholar
25.Katsarava, Z, Muessig, M, Dzagnidze, A, et al. Medication overuse headache: rates and predictors for relapse in a 4-year prospective study. 2005;25(1):1215.Google Scholar
26.Zeeberg, P, Olesen, J, Jensen, R. Probable medication-overuse headache: the effect of a 2-month drug-free period. Neurology. 2006;66(12):1894–8.CrossRefGoogle ScholarPubMed
27.Munksgaard, SB, Bendtsen, L, Jensen, RH. Treatment‐resistant medication overuse headache can be cured. Headache. 2012;52(7):1120–9.Google Scholar
28.Relja, G, Granato, A, Bratina, A, Antonello, RM, Zorzon, M. Outcome of medication overuse headache after abrupt in-patient withdrawal. Cephalalgia. 2006;26(5):589–95.Google Scholar
29.Katsarava, Z, Limmroth, V, Finke, M, Diener, HC, Fritsche, G. Rates and predictors for relapse in medication overuse headache: a 1-year prospective study. Neurology. 2003;60(10):1682–3.Google Scholar
30.Zidverc-Trajkovic, J, Pekmezovic, T, Jovanovic, Z, et al. Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up. Cephalalgia. 2007;27(11):1219–25.Google Scholar
31.Fontanillas, N, Colás, R, Muñoz, P, Oterino, A, Pascual, J. Long-term evolution of chronic daily headache with medication overuse in the general population. Headache. 2010;50(6):981–8.Google Scholar
32.Sances, G, Ghiotto, N, Galli, F, et al. Risk factors in medication-overuse headache: a 1-year follow-up study (care II protocol). Cephalalgia. 2010;30(3):329–36.Google Scholar
33.Zeeberg, P, Olesen, J, Jensen, R. Discontinuation of medication overuse in headache patients: recovery of therapeutic responsiveness. Cephalalgia. 2006;26(10):1192–8.CrossRefGoogle ScholarPubMed
34.Lake, AE, Saper, JR, Hamel, RL. Comprehensive inpatient treatment of refractory chronic daily headache. Headache. 2009;49(4):555–62.CrossRefGoogle ScholarPubMed
35.Bøe, MG, Mygland, Å, Salvesen, R. Prednisolone does not reduce withdrawal headache: a randomized, double-blind study. Neurology. 2007;69(1):2631.Google Scholar
36.Pageler, L, Katsarava, Z, Diener, HC, Limmroth, V. Prednisone vs. placebo in withdrawal therapy following medication overuse headache. Cephalalgia. 2008;28(2):152–6.Google Scholar
37.Krymchantowski, AV, Barbosa, JS. Prednisone as initial treatment of analgesic-induced daily headache. Cephalalgia. 2000;20(2):107–13.CrossRefGoogle ScholarPubMed
38.Evers, S, Jensen, R, European Federation of Neurological Societies. Treatment of medication overuse headache: guideline of the EFNS headache panel. Eur J Neurol. 2011;18(9):1115–21.CrossRefGoogle ScholarPubMed
39.Garza, I, Schwedt, TJ. Medication Overuse Headache: Treatment and Prognosis. 10th ed. Waltham: UpTo-Date; 2012.Google Scholar
40.Dodick, DW, Silberstein, SD. How clinicians can detect, prevent and treat medication overuse headache. Cephalalgia. 2008;28(11):1207–17.Google Scholar
41.Bigal, ME, Lipton, RB. Modifiable risk factors for migraine progression. Headache. 2006;46(9):1334–43.Google ScholarPubMed
42.Aurora, SK, Winner, P, Freeman, MC, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical program. Headache. 2011;51(9):1358–73.Google Scholar
43.Silberstein, S, Lipton, R, Dodick, D, et al. Topiramate treatment of chronic migraine: a randomized, placebo-controlled trial of quality of life and other efficacy measures. 2009;49(8):1153–62.CrossRefGoogle Scholar
44.AAN (American Academy of Neurology). Clinical Practice Guideline Process Manual, 2011 ed. St. Paul, MN: The American Academy of Neurology; 2011.Google Scholar
45.Tassorelli, C, Jensen, R, Allena, M, et al. A consensus protocol for the management of medication-overuse headache: evaluation in a multicentric, multinational study. Cephalalgia. 2014;34(9):645–55.CrossRefGoogle Scholar
46.Dodick, DW, Turkel, CC, DeGryse, RE, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program. Headache. 2010;50(6):921–36.Google Scholar
47.Silberstein, SD, Blumenfeld, AM, Cady, RK, et al. OnabotulinumtoxinA for treatment of chronic migraine: PREEMPT 24-week pooled subgroup analysis of patients who had acute headache medication overuse at baseline. J Neurol Sci. 2013;331(12):4856.Google Scholar
48.Silberstein, SD, Lipton, RB, Dodick, DW, et al. Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. 2007;47(2):170–80.Google Scholar
49.Diener, HC, Dodick, DW, Aurora, SK, et al. OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia. 2010;30(7):804–14.Google Scholar
50.Diener, HC, Bussone, G, Van Oene, JC, et al. Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia. 2007;27(7):814–23.Google Scholar
51.Colman, I, Rothney, A, Wright, SC, Zilkalns, B, Rowe, BH. Use of narcotic analgesics in the emergency department treatment of migraine headache. Neurology. 2004;62(10):1695–700.CrossRefGoogle ScholarPubMed
52.Del Portal, DA, Healy, ME, Satz, WA, McNamara, RM. Impact of an opioid prescribing guideline in the acute care setting. J Emerg Med. 2016;50(1):21–7.Google Scholar
53.Hoppe, JA, Kim, H, Heard, K. Association of emergency department opioid initiation with recurrent opioid use. Ann Emerg Med. 2015;65(5):493–4.Google Scholar
54.Minen, MT, Lindberg, K, Wells, RE, et al. Survey of opioid and barbiturate prescriptions in patients attending a tertiary care headache center. 2015;55(9):1183–91.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×