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Chapter 51 - Mental Health Disorders in Pregnancy (Content last reviewed: 14th December 2020)

from Section 5 - Late Pregnancy – Maternal Problems

Published online by Cambridge University Press:  15 November 2017

By
Ben Di Mambro  and
Zena Schofield
Edited by
David James ,
Philip Steer ,
Carl Weiner ,
Bernard Gonik  and
Stephen Robson
David James
Affiliation:
University of Nottingham
Philip Steer
Affiliation:
Imperial College London
Carl Weiner
Affiliation:
University of Kansas
Bernard Gonik
Affiliation:
Wayne State University, Detroit
Stephen Robson
Affiliation:
University of Newcastle
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Summary

Mental health disorders are common in pregnancy and after childbirth, and maternity services will encounter symptoms that vary in severity from the mild self-limiting to the potentially life-threatening as part of daily practice. Detecting women with, or at risk of, a serious mental health disorder and accessing appropriate care in a timely fashion is a shared responsibility. However, given the frequency of contact maternity service have with women through this period, maternity services have a pivotal role. From a mental health perspective, high-risk pregnancies are primarily associated with serious mental illness (psychotic illnesses and severe depressive episodes). However, given the challenges in interpreting emerging anxiety and mood symptoms, clinicians require a broader understanding of mental health presentations.

Type
Chapter
Information
High-Risk Pregnancy
Management Options
 , pp. 1500 - 1522
Publisher: Cambridge University Press
First published in: 2017

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References

Cox, JL, Murray, D, Chapman, G. A controlled study of the onset, duration and prevalence of postnatal depression. Br J Psychiatry 1993; 163: 27–31.CrossRefGoogle ScholarPubMed
Joint Commissioning Panel for Mental Health. Guidance for Commissioners of Perinatal Mental Health Services. Volume Two: Practical Mental Health Commissioning. London: JCPMH, 2012. http://www.rcpsych.ac.uk/pdf/perinatal_web.pdf (accessed March 2017).Google Scholar
Confidential Enquiries into Maternal Deaths. Why Mothers Die 2000–2002: The Sixth Report of the Confidential Enquiries into Maternal Deaths in the UK. London: Royal College of Obstetricians and Gynaecologists, 2004.Google Scholar
Lewis, G, Clutton-Brock, T, Cooper, G, et al. Saving Mothers’ Lives: Reviewing Maternal Deaths to Make Motherhood Safer – 2003 to 2005. The Seventh Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. London, CEMACH, 2007.Google Scholar
Cantwell, R, Clutton-Brock, T, Cooper, G, et al. Saving mothers’ lives: reviewing maternal deaths to make motherhood safer: 2006–2008. The Eight Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG 2011; 118 (Suppl 1): 1–203.Google Scholar
Knight, M, Bunch, K, Tuffnell, D, et al. Saving Lives, Improving Mothers’ Care: Lessons Learned to Inform Maternity Care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2014–16. Oxford: National Perinatal Epidemiology Unit, University of Oxford 2018.Google Scholar
National Institute for Health and Care Excellence (NICE). Antenatal and Postnatal Mental Health: Clinical Management and Service Guidance. Clinical Guideline 192. London: NICE, 2014 (updated February 2020). www.nice.org.uk/guidance/cg192 (accessed February 2020).Google Scholar
Scottish Intercollegiate Guidelines Network. Management of Perinatal Mood Disorders: A National Clinical Guideline. SIGN 127. Edinburgh: SIGN, 2012. http://sign.ac.uk/guidelines/fulltext/127 (accessed March 2017).Google Scholar
NHS England. NHS Five Year Forward View. London: NHS, 2014.Google Scholar
NHS England. The NHS Long Term Plan. London: NHS, 2019. www.longtermplan.nhs.uk (accessed February 2020).Google Scholar
Oates, M. Suicide: the leading cause of maternal death. Br J Psychiatry 2003; 183: 279–81.Google Scholar
Stein, A, Pearson, RM, Goodman, SH. Effects of perinatal mental disorders on the fetus and child. Lancet 2014; 384: 1800–17.Google Scholar
McAllister-Williams, RH, Baldwin, DS, Cantwell, R, et al. British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017. J Psychopharmacol 2017; 31: 519–52. doi: 10.1177/0269881117699361.Google Scholar
Di Florio, A, Forty, L, Gordon-Smith, K, et al. Perinatal episodes across the mood disorder spectrum. JAMA Psychiatry 2013; 70: 168–75.CrossRefGoogle ScholarPubMed
World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. Geneva: World Health Organization, 1993.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th edn. Arlington, VA: American Psychiatric Publishing, 2013.Google Scholar
Gavin, NI, Gaynes, BN, Lohr, KN, et al. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol 2005; 106: 1071–83.Google Scholar
Henshaw, C, Foreman, D, Cox, J. Postnatal blues: a risk factor for postnatal depression. J Psychosom Obstet Gynaecol 2004; 25: 267–72.Google Scholar
Parsons, CE, Young, KS, Rochat, TJ, Kringelbach, ML, Stein, A. Postnatal depression and its effects on child development: a review of evidence from low- and middle-income countries. Br Med Bull 2012; 101: 57–79.Google Scholar
O’Hara, MW, Swain, AM. Rates and risk of postpartum depression – a meta-analysis. Int Rev Psychiatry 1996; 8: 87–98.Google Scholar
Munk-Olsen, T, Laursen, TM, Pedersen, CB, Mors, O, Mortensen, PB. New parents and mental disorders: a population-based register study. JAMA 2006; 296: 2582–9.Google Scholar
Josefsson, A, Angelsiöö, L, Berg, G, et al. Obstetric, somatic, and demographic risk factors for postpartum depressive symptoms. Obstet Gynecol 2002; 99: 223–8.Google Scholar
Cooper, C, Jones, L, Dunn, E, et al. Clinical presentation of postnatal and non-postnatal depressive episodes. Psychol Med 2007; 37: 1273–80.CrossRefGoogle ScholarPubMed
Nylen, KJ, Williamson, JA, O’Hara, MW, Watson, D, Engeldinger, J. Validity of somatic symptoms as indicators of depression in pregnancy. Arch Womens Ment Health 2013; 16: 1–8.CrossRefGoogle ScholarPubMed
Dayan, J, Creveuil, C, Dreyfus, M, et al. Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress. PLoS One 2010; 22: e12942.Google Scholar
Forty, L, Jones, L, Macgregor, S, et al. Familiality of postpartum depression in unipolar disorder: results of a family study. Am J Psychiatry 2006; 163: 1549–53.Google Scholar
Forman, ND, Videbech, P, Hedegaard, M, Dalby Salvig, J, Secher, NJ. Postpartum depression: identification of women at risk. BJOG 2000; 107: 1210–17.Google Scholar
Brockington, IF, Aucamp, HM, Fraser, C. Severe disorders of the mother–infant relationship: definitions and frequency. Arch Womens Ment Health 2006; 9: 243–51.Google Scholar
Howard, LM, Oram, S, Galley, H, Trevillion, K, Feder, G. Domestic violence and perinatal mental disorders: a systematic review and meta-analysis. PLoS Med 2013; 10: e1001452.Google Scholar
Talge, NM, Neal, C, Glover, V. Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J Child Psychol Psychiatry 2007; 48: 245–61.CrossRefGoogle ScholarPubMed
Brown, AS, van Os, J, Driessens, C, Hoek, HW, Susser, ES. Further evidence of relation between prenatal famine and major affective disorder. Am J Psychiatry 2000; 157: 190–5.CrossRefGoogle ScholarPubMed
Grigoriadis, S, VonderPorten, EH, Mamisashvili, L, et al. The impact of maternal depression during pregnancy on perinatal outcomes: a systematic review and meta-analysis. J Clin Psychiatry 2013; 74: e321–41.CrossRefGoogle ScholarPubMed
Grote, NK, Bridge, JA, Gavin, AR, et al. A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Arch Gen Psychiatry 2010; 67: 1012–24.Google Scholar
Pearson, RM, Evans, J, Kounali, D, et al. Maternal depression during pregnancy and the postnatal period: risks and possible mechanisms for offspring depression at age 18 years. JAMA Psychiatry 2013 Dec; 70: 1312–19. doi: 10.1001/jamapsychiatry.2013.2163.Google Scholar
O’Donnell, KJ, Glover, V, Barker, ED, O’Connor, TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Dev Psychopathol 2014; 26: 393–403. doi: 10.1017/S0954579414000029.CrossRefGoogle ScholarPubMed
Capron, LE, Glover, V, Pearson, RM, et al. Associations of maternal and paternal antenatal mood with offspring anxiety disorder at age 18 years. J Affect Disord 2015; 187: 20–6. doi: 10.1016/j.jad.2015.08.012.CrossRefGoogle ScholarPubMed
Cohen, LS, Altshuler, LL, Harlow, BL, et al. Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment. JAMA 2006; 295: 499–507.Google Scholar
Ross, LE, Grigoriadis, S, Mamisashvili, L, et al. Selected pregnancy and delivery outcomes after exposure to antidepressant medication: a systematic review and meta-analysis. JAMA Psychiatry 2013; 70: 436–43.Google Scholar
Huybrechts, KF, Palmsten, K, Avorn, J, et al. Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med 2014; 370: 2397–407.CrossRefGoogle ScholarPubMed
Grigoriadis, S, VonderPorten, EH, Mamisashvili, L, et al. Antidepressant exposure during pregnancy and congenital malformations: is there an association? A systematic review and meta-analysis of the best evidence. J Clin Psychiatry 2013; 74: e293–308.Google Scholar
Bérard, A, Iessa, N, Chaabane, S, et al. The risk of major cardiac malformations associated with paroxetine use during the first trimester of pregnancy: a systematic review and meta-analysis. Br J Clin Pharmacol 2016; 81: 589–604. doi: 10.1111/bcp.12849.Google Scholar
Hemels, ME, Einarson, A, Koren, G, Lanctôt, KL, Einarson, TR. Antidepressant use during pregnancy and the rates of spontaneous abortions: a meta-analysis. Ann Pharmacother 2005; 39: 803–9.CrossRefGoogle ScholarPubMed
Yonkers, KA, Blackwell, KA, Glover, J, Forray, A. Antidepressant use in pregnant and postpartum women. Annu Rev Clin Psychol 2014; 10: 369–92.Google Scholar
Grigoriadis, S, Vonderporten, EH, Mamisashvili, L, et al. Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis. BMJ 2014; 348: f6932.Google Scholar
Masarwa, R, Bar-Oz, B, Gorelik, E, et al. Prenatal exposure to selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors and risk for persistent pulmonary hypertension of the newborn: a systematic review, meta-analysis, and network meta-analysis. Am J Obstet Gynecol 2019; 220: 57.e1–57.e13. doi: 10.1016/j.ajog.2018.08.030.Google Scholar
Croen, LA, Grether, JK, Yoshida, CK, Odouli, R, Hendrick, V. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011; 68: 1104–12.Google Scholar
Man, KK, Tong, HH, Wong, LY, et al. Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: a systematic review and meta-analysis of observational studies. Neurosci Biobehav Rev 2015; 49: 82–9.CrossRefGoogle ScholarPubMed
Kaplan, YC, Keskin-Arslan, E, Acar, S, Sozmen, K. Maternal SSRI discontinuation, use, psychiatric disorder and the risk of autism in children: a meta-analysis of cohort studies. Br J Clin Pharmacol 2017; 83: 2798–806. doi: 10.1111/bcp.13382.CrossRefGoogle ScholarPubMed
Hviid, A, Melbye, M, Pasternak, B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013; 369: 2406–15.Google Scholar
Vega, ML, Newport, GC, Bozhdaraj, D, et al. Implementation of advanced methods for reproductive pharmacovigilance in autism: a meta-analysis of the effects of prenatal antidepressant exposure. Am J Psychiatry 2020; 177: 506–17. https://doi.org/10.1176/appi.ajp.2020.18070766.Google Scholar
Clements, CC, Castro, VM, Blumenthal, SR, et al. Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Mol Psychiatry 2015; 20: 727–34.Google Scholar
Grigoriadis, S, VonderPorten, EH, Mamisashvili, L, et al. The effect of prenatal antidepressant exposure on neonatal adaptation: a systematic review and meta-analysis. J Clin Psychiatry 2013; 74: e309–20.Google Scholar
Fenger-Grøn, J, Thomsen, M, Andersen, KS, Nielsen, RG. Paediatric outcomes following intrauterine exposure to serotonin reuptake inhibitors: a systematic review. Dan Med Bull 2011; 58: A4303.Google Scholar
Klinger, G, Frankenthal, D, Merlob, P, et al. Long-term outcome following selective serotonin reuptake inhibitor induced neonatal abstinence syndrome. J Perinatol. 2011; 31: 615–20.Google Scholar
Kim, DR, Epperson, N, Paré, E, et al. An open label pilot study of transcranial magnetic stimulation for pregnant women with major depressive disorder. J Womens Health (Larchmt) 2011; 20: 255–61.Google Scholar
Pompili, M, Dominici, G, Giordano, G, et al. Electroconvulsive treatment during pregnancy: a systematic review. Expert Rev Neurother 2014; 14: 1377–90.CrossRefGoogle ScholarPubMed
Leiknes, KA, Cooke, MJ, Jarosch-von Schweder, L, Harboe, I, Høie, B. Electroconvulsive treatment during pregnancy: a systematic review. Arch Womens Ment Health 2015; 18: 1–39.Google Scholar
Dennis, CL, Dowswell, T. Psychosocial and psychological interventions for preventing postpartum depression. Cochrane Database Syst Rev 2013; (2): CD001134.Google Scholar
Sockol, LE, Epperson, CN, Barber, JP. Preventing postpartum depression: a meta-analytic review. Clin Psychol Rev 2013; 33: 1205–17.Google Scholar
Dennis, CL, Hodnett, E. Psychosocial and psychological interventions for treating postpartum depression. Cochrane Database Syst Rev 2007; (4): CD006116.Google Scholar
Molyneaux, E, Howard, LM, McGeown, HR, Karia, AM, Trevillion, K. Antidepressant treatment for postnatal depression. Cochrane Database Syst Rev 2014; (9): CD002018.CrossRefGoogle Scholar
Sinyor, M, Schaffer, A, Levitt, A. The sequenced treatment alternatives to relieve depression (STAR*D) trial: a review. Can J Psychiatry 2010; 55: 126–35.CrossRefGoogle ScholarPubMed
UK ECT Review Group. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet 2003; 361: 799–808.Google Scholar
Semkovska, M, McLoughlin, DM. Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis. Biol Psychiatry 2010; 68: 568–77.CrossRefGoogle ScholarPubMed
Murrough, JW, Iosifescu, DV, Chang, LC, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry 2013; 170: 1134–42.Google Scholar
Gaynes, BN, Lloyd, SW, Lux, L, et al. Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis. J Clin Psychiatry 2014; 75: 477–89.CrossRefGoogle ScholarPubMed
National Institute for Health and Care Excellence (NICE). Bipolar Disorder: Assessment and Management. Clinical Guideline 185. London: NICE, 2014. https://www.nice.org.uk/guidance/cg185 (accessed March 2017).Google Scholar
Dierckx, B, Heijnen, WT, van den Broek, WW, Birkenhager, TK. Efficacy of electroconvulsive therapy in bipolar versus unipolar major depression: a meta-analysis. Bipolar Disord 2012; 14: 146–50.Google Scholar
Judd, LL, Akiskal, HS, Schettler, PJ, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry 2002; 59: 530–7.Google Scholar
Merikangas, KR, Akiskal, HS, Angst, J, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2007; 64 (5): 543–52.Google Scholar
Yonkers, KA, Vigod, S, Ross, LE. Diagnosis, pathophysiology, and management of mood disorders in pregnant and postpartum women. Obstet Gynecol 2011; 117: 961–77.Google Scholar
Viguera, AC, Tondo, L, Koukopoulos, AE, et al. Episodes of mood disorders in 2,252 pregnancies and postpartum periods. Am J Psychiatry 2011; 168: 1179–85.Google Scholar
Jones, I, Craddock, N. Familiality of the puerperal trigger in bipolar disorder: results of a family study. Am J Psychiatry 2001; 158: 913–17.Google Scholar
Jablensky, AV, Morgan, V, Zubrick, SR, Bower, C, Yellachich, LA. Pregnancy, delivery, and neonatal complications in a population cohort of women with schizophrenia and major affective disorders. Am J Psychiatry 2005; 162: 79–91.Google Scholar
Bodén, R, Lundgren, M, Brandt, L, et al. Risks of adverse pregnancy and birth outcomes in women treated or not treated with mood stabilisers for bipolar disorder: population based cohort study. BMJ. 2012; 345: e7085.Google Scholar
Freeman, MP. Bipolar disorder and pregnancy: risks revealed. Am J Psychiatry 2007; 164: 1771–3.Google Scholar
National Institute for Health and Care Excellence (NICE). Antenatal and Postnatal Mental Health: Quality statement 1: Valproate. London: NICE, 2016. www.nice.org.uk/guidance/qs115/chapter/Quality-statement-1-Valproate (accessed February 2020).Google Scholar
Kendell, RE, Chalmers, JC, Platz, C. Epidemiology of puerperal psychoses. Br J Psychiatry 1987; 150: 662–73.Google Scholar
Epstein, RA, Bobo, WV, Shelton, RC, et al. Increasing use of atypical antipsychotics and anticonvulsants during pregnancy. Pharmacoepidemiol Drug Saf 2013; 22: 794–801.Google Scholar
Gentile, S. Antipsychotic therapy during early and late pregnancy: a systematic review. Schizophr Bull 2010; 36: 518–44.Google Scholar
Einarson, A, Boskovic, R. Use and safety of antipsychotic drugs during pregnancy. J Psychiatr Pract 2009; 15: 183–92.Google Scholar
Damkier, P, Videbech, P. The safety of second-generation antipsychotics during pregnancy: a clinically focused review. CNS Drugs 2018; 32: 351–66. doi: 10.1007/s40263-018-0517-5.Google Scholar
Boden, R, Lundgren, M, Brandt, L, Reutfors, J, Kieler, H. Antipsychotics during pregnancy: relation to fetal and maternal metabolic effects. Arch Gen Psychiatry 2012; 69: 715–21. doi: 10.1001/archgenpsychiatry.2011.1870.Google Scholar
Ellfolk, M, Leinonen, MK, Gissler, M, et al. Second-generation antipsychotics and pregnancy complications. Eur J Clin Pharmacol 2020; 76: 107–15. https://doi.org/10.1007/s00228-019-02769-z.Google Scholar
Vigod, SN, Gomes, T, Wilton, AS, Taylor, VH, Ray, JG. Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study. BMJ 2015; 350: h2298. doi: 10.1136/bmj.h2298.Google Scholar
Galbally, M, Frayne, J, Watson, SJ, Morgan, V, Snellen, M. The association between gestational diabetes mellitus, antipsychotics and severe mental illness in pregnancy: a multicentre study. Aust N Z J Obstet Gynaecol 2020; 60: 63–9. https://doi.org/10.1111/ajo.12986.Google Scholar
Viguera, AC, Nonacs, R, Cohen, LS, et al. Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance. Am J Psychiatry 2000; 157: 179–84.Google Scholar
Viguera, AC, Whitfield, T, Baldessarini, RJ, et al. Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation. Am J Psychiatry 2007; 164: 1817–24.Google Scholar
Nora, JJ, Nora, AH, Toews, WH. Letter: lithium, Ebstein’s anomaly, and other congenital heart defects. Lancet 1974; 2: 594–5.Google Scholar
Yacobi, S, Ornoy, A. Is lithium a real teratogen? What can we conclude from the prospective versus retrospective studies? A review. Isr J Psychiatry Relat Sci 2008; 45: 95–106.Google Scholar
McKnight, RF, Adida, M, Budge, K, et al. Lithium toxicity profile: a systematic review and meta-analysis. Lancet 2012; 379: 721–8.CrossRefGoogle ScholarPubMed
Gutgesell, H. Lithium use in pregnancy and the risk of cardiac malformations. N Engl J Med 2017; 377: 893. doi: 10.1056/NEJMc1708919.Google ScholarPubMed
Kozma, C. Neonatal toxicity and transient neurodevelopmental deficits following prenatal exposure to lithium: another clinical report and a review of the literature. Am J Med Genet A 2005; 132A: 441–4.Google Scholar
Meador, K, Reynolds, MW, Crean, S, Fahrbach, K, Probst, C.Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 2008; 81: 1–13.Google Scholar
Jentink, J, Bakker, MK, Nijenhuis, CM, Wilffert, B, de Jong-van den Berg, LT. Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid? Pharmacoepidemiol Drug Saf 2010; 19: 803–7.CrossRefGoogle ScholarPubMed
Medicines and Healthcare products Regulatory Agency. Valproate use by women and girls. 2018. www.gov.uk/guidance/valproate-use-by-women-and-girls (accessed February 2020).Google Scholar
McCorry, D, Bromley, R. Does in utero exposure of antiepileptic drugs lead to failure to reach full cognitive potential? Seizure 2015; 28: 51–6.Google Scholar
Tomson, T, Battino, D. Teratogenic effects of antiepileptic drugs. Lancet Neurol 2012; 11: 803–13.Google Scholar
Bergink, V, Burgerhout, KM, Koorengevel, KM, et al. Treatment of psychosis and mania in the postpartum period. Am J Psychiatry 2015; 172: 115–23.Google Scholar
Lawson, A, Murphy, KE, Sloan, E, Uleryk, E, Dalfen, A. The relationship between sleep and postpartum mental disorders: a systematic review. J Affect Disord 2015; 176: 65–77.Google Scholar
Chandra, PS, Bhargavaraman, RP, Raghunandan, VN, Shaligram, D. Delusions related to infant and their association with mother–infant interactions in postpartum psychotic disorders. Arch Womens Ment Health 2006; 9: 285–8.Google Scholar
Di Florio, A, Jones, L, Forty, L, et al. Mood disorders and parity: a clue to the aetiology of the postpartum trigger. J Affect Disord 2014; 152–154: 334–39.Google Scholar
Blackmore, ER, Jones, I, Doshi, M, et al. Obstetric variables associated with bipolar affective puerperal psychosis. Br J Psychiatry 2006; 188:32–6.CrossRefGoogle ScholarPubMed
Heron, J, Robertson Blackmore, E, McGuinness, M, Craddock, N, Jones, I. No “latent period” in the onset of bipolar affective puerperal psychosis. Arch Womens Ment Health 2007; 10: 79–81.Google Scholar
Heron, J, McGuinness, M, Blackmore, ER, Craddock, N, Jones, I. Early postpartum symptoms in puerperal psychosis. BJOG 2008; 115: 348–53.Google Scholar
Jones, I, Smith, S. Puerperal psychosis: identifying and caring for women at risk. Adv Psychiatr Treat 2009; 15: 411–18.Google Scholar
Doucet, S, Jones, I, Letourneau, N, Dennis, CL, Blackmore, ER. Interventions for the prevention and treatment of postpartum psychosis: a systematic review. Arch Womens Ment Health 2010; 14: 89–98.Google Scholar
Focht, A, Kellner, CH. Electroconvulsive therapy (ECT) in the treatment of postpartum psychosis. J ECT. 2012; 28: 31–3.Google Scholar
Robertson, E, Jones, I, Haque, S, Holder, R, Craddock, N. Risk of puerperal and non-puerperal recurrence of illness following bipolar affective puerperal (post-partum) psychosis. Br J Psychiatry 2005; 186: 258–9.CrossRefGoogle ScholarPubMed
Blackmore, ER, Rubinow, DR, O’Connor, TG, et al. Reproductive outcomes and risks of subsequent illness in women diagnosed with postpartum psychosis. Bipolar Disord 2013; 15: 394–404.Google Scholar
Blanchard, JJ, Kring, AM, Horan, WP, Gur, R. Toward the next generation of negative symptom assessments: the collaboration to advance negative symptom assessment in schizophrenia. Schizophr Bull 2011; 37: 291–9.Google Scholar
Judd, F, Komiti, A, Sheehan, P, et al. Adverse obstetric and neonatal outcomes in women with severe mental illness: to what extent can they be prevented? Schizophr Res 2014; 157: 305–9.Google Scholar
Howard, LM. Fertility and pregnancy in women with psychotic disorders. Eur J Obstet Gynecol Reprod Biol 2005; 119: 3–10.Google Scholar
Taylor, CL, Stewart, R, Ogden, J, et al. The characteristics and health needs of pregnant women with schizophrenia compared with bipolar disorder and affective psychoses. BMC Psychiatry 2015; 15: 88.Google Scholar
Vigod, SN, Kurdyak, PA, Dennis, CL, et al. Maternal and newborn outcomes among women with schizophrenia: a retrospective population-based cohort study. BJOG 2014; 121: 566–74.Google Scholar
Bennedsen, BE, Mortensen, PB, Olesen, AV, Henriksen, TB, Frydenberg, M. Obstetric complications in women with schizophrenia. Schizophr Res 2001; 47: 167–75.CrossRefGoogle ScholarPubMed
Miller, LJ. Sexuality, reproduction, and family planning in women with schizophrenia. Schizophr Bull 1997; 23: 623–35.Google Scholar
Matevosyan, NR. Pregnancy and postpartum specifics in women with schizophrenia: a meta-study. Arch Gynecol Obstet 2011; 283: 141–7.Google Scholar
Henriksson, KM, McNeil, TF. Health and development in the first 4 years of life in offspring of women with schizophrenia and affective psychoses: Well-Baby Clinic information. Schizophr Res 2004; 70: 39–48.Google Scholar
Bundy, H, Stahl, D, MacCabe, JH. A systematic review and meta-analysis of the fertility of patients with schizophrenia and their unaffected relatives. Acta Psychiatr Scand 2011; 123: 98–106.Google Scholar
Vigod, SN, Seeman, MV, Ray, JG, et al. Temporal trends in general and age-specific fertility rates among women with schizophrenia (1996–2009): a population-based study in Ontario, Canada. Schizophr Res 2012; 139: 169–75.Google Scholar
Mehta, TM, Van Lieshout, RJ. A review of the safety of clozapine during pregnancy and lactation. Arch Womens Ment Health 2017; 20: 1–9. doi: 10.1007/s00737-016-0670-0.Google Scholar
Kenny, M, Conroy, S, Pariante, CM, Seneviratne, G, Pawlby, S. Mother–infant interaction in mother and baby unit patients: before and after treatment. J Psychiatr Res 2013; 47: 1192–8.Google Scholar
Leucht, S, Tardy, M, Komossa, K, et al. Maintenance treatment with antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev 2012; (5): CD008016.Google Scholar
Heron, J, O’Connor, TG, Evans, J, Golding, J, Glover, V. The course of anxiety and depression through pregnancy and the postpartum in a community sample. J Affect Disord 2004; 80: 65–73.Google Scholar
Matthey, S, Barnett, B, Howie, P, Kavanagh, DJ. Diagnosing postpartum depression in mothers and fathers: whatever happened to anxiety? J Affect Disord 2003; 74: 139–47.Google Scholar
Zhang, S, Ding, Z, Liu, H, et al. Association between mental stress and gestational hypertension/preeclampsia: a meta-analysis. Obstet Gynecol Surv 2013; 68: 825–34.Google Scholar
Goodman, JH, Chenausky, KL, Freeman, MP. Anxiety disorders during pregnancy: a systematic review. J Clin Psychiatry 2014; 75: e1153–84.Google Scholar
Ding, XX, Wu, YL, Xu, SJ, et al. Maternal anxiety during pregnancy and adverse birth outcomes: a systematic review and meta-analysis of prospective cohort studies. J Affect Disord 2014; 159: 103–10.Google Scholar
Littleton, HL, Breitkopf, CR, Berenson, AB. Correlates of anxiety symptoms during pregnancy and association with perinatal outcomes: a meta-analysis. Am J Obstet Gynecol 2007; 196: 424–32.Google Scholar
O’Connor, TG, Heron, J, Golding, J, Beveridge, M, Glover, V. Maternal antenatal anxiety and children’s behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children. Br J Psychiatry 2002; 180: 502–8.Google Scholar
Pemberton, CK, Neiderhiser, JM, Leve, LD, et al. Influence of parental depressive symptoms on adopted toddler behaviors: an emerging developmental cascade of genetic and environmental effects. Dev Psychopathol 2010; 22: 803–18.Google Scholar
Timpano, KR, Abramowitz, JS, Mahaffey, BL, Mitchell, MA, Schmidt, NB. Efficacy of a prevention program for postpartum obsessive-compulsive symptoms. J Psychiatr Res 2011; 45: 1511–17.Google Scholar
Milgrom, J, Schembri, C, Ericksen, J, Ross, J, Gemmill, AW. Towards parenthood: an antenatal intervention to reduce depression, anxiety and parenting difficulties. J Aff ect Disord 2011; 130: 385–94.Google Scholar
National Institute for Health and Care Excellence (NICE). Generalised Anxiety Disorder and Panic Disorder in Adults. Clinical Guideline 192. London: NICE, 2011. www.nice.org.uk/guidance/cg113 (accessed February 2020).Google Scholar
Okun, M, Ebert, R, Saini, B. A review of sleep-promoting medications used in pregnancy. Am J Obstet Gynecol 2015; 212: 428–41. doi: 10.1016/j.ajog.2014.10.1106.Google Scholar
Bellantuono, C, Tofani, S, Di Sciascio, G, et al. Benzodiazepine exposure in pregnancy and risk of major malformations: a critical overview. Gen Hosp Psychiatry 2013; 35: 3–8. doi: 10.1016/j.genhosppsych.2012.09.003.Google Scholar
Enato, E, Moretti, M, Koren, G. The fetal safety of benzodiazepines: an updated meta-analysis. J Obstet Gynaecol Can 2011; 33: 46–8.Google Scholar
Oberlander, TF, Warburton, W, Misri, S, et al. Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health data. Birth Defects Res B Dev Reprod Toxicol 2008; 83: 68–76.Google Scholar

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