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Chapter 45 - Renal Disorders in Pregnancy (Content last reviewed: 15th October 2018)

from Section 5 - Late Pregnancy – Maternal Problems

Published online by Cambridge University Press:  15 November 2017

David James
Affiliation:
University of Nottingham
Philip Steer
Affiliation:
Imperial College London
Carl Weiner
Affiliation:
University of Kansas
Bernard Gonik
Affiliation:
Wayne State University, Detroit
Stephen Robson
Affiliation:
University of Newcastle
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Summary

Renal disease complicates a small proportion of pregnancies worldwide. The incidence of acute kidney injury (AKI) in pregnancy is declining worldwide as a result of improved surveillance, identification, and management of preeclampsia, hemorrhage, and septic complications. Conversely, more women with chronic kidney disease (CKD) are contemplating pregnancy. This is a result of (a) increased recognition of early CKD because of estimated glomerular filtration rate (eGFR) reporting, (b) increasing maternal age in many parts of the world, and (c) improved maternal outcomes from renal diseases and treatments that might have led to impaired fertility in the past.

Type
Chapter
Information
High-Risk Pregnancy
Management Options
, pp. 1321 - 1365
Publisher: Cambridge University Press
First published in: 2017

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References

Renal Association. Acute kidney injury: guidelines. http://www.renal.org/guidelines/modules/acute-kidney-injury (accessed March 2017).Google Scholar
Gurrieri, C, Garovic, VD, Gullo, A, et al. Kidney injury during pregnancy: associated comorbid conditions and outcomes. Arch Gynecol Obstet 2012; 286: 567–73.CrossRefGoogle ScholarPubMed
Bentata, Y, Housni, B, Mimouni, A, Azzouzi, A, Abouqal, R. Acute kidney injury related to pregnancy in developing countries: etiology and risk factors in an intensive care unit. J Nephrol 2012; 25: 764–75.Google Scholar
Acharya, A, Santos, J, Linde, B, Anis, K. Acute kidney injury in pregnancy-current status. Adv Chronic Kidney Dis 2013; 20: 215–22.Google Scholar
Williams, D, Davison, J. Chronic kidney disease in pregnancy. BMJ 2008; 336: 211–15.Google Scholar
Okundaye, I, Abrinko, P, Hou, S. Registry of pregnancy in dialysis patients. Am J Kidney Dis 1998; 31: 766–73.Google Scholar
Brown, JH, Maxwell, AP, McGeown, MG. Outcome of pregnancy following renal transplantation. Ir J Med Sci 1991; 160: 255–6.Google Scholar
Hussein, W, Lafayette, RA. Renal function in normal and disordered pregnancy. Curr Opin Nephrol Hypertens 2014; 23: 4653.Google Scholar
Odutayo, A, Hladunewich, M. Obstetric nephrology: renal hemodynamic and metabolic physiology in normal pregnancy. Clin J Am Soc Nephrol 2012; 7: 2073–80.CrossRefGoogle ScholarPubMed
Higby, K, Suiter, CR, Phelps, JY. Normal values of urinary albumin and total protein excretion during pregnancy. Am J Obstet Gynecol 1994; 171: 984–9.CrossRefGoogle ScholarPubMed
Erman, A, van Dyk, DJ, Rabinov, M, Boner, G, Rosenfeld, JB. Urinary albumin excretion in the healthy population. Isr J Med Sci 1990; 26: 389–92.Google Scholar
Hytten, FE, Thomson, AM, Taggart, N. Total body water in normal pregnancy. J Obstet Gynaecol Br Commonw 1966; 73: 553–61.Google Scholar
Davison, JM, Lindheimer, MD. Volume homeostasis and osmoregulation in human pregnancy. Baillieres Clin Endocrinol Metab 1989; 3: 451–72.Google Scholar
Machado, S, Figueiredo, N, Borges, A, et al. Acute kidney injury in pregnancy: a clinical challenge. J Nephrol 2012; 25: 1930.Google Scholar
Ganesan, C, Maynard, SE. Acute kidney injury in pregnancy: the thrombotic microangiopathies. J Nephrol 2011; 24: 554–63.CrossRefGoogle ScholarPubMed
Silva, GB, Monteiro, FA, Mota, RM, et al. Acute kidney injury requiring dialysis in obstetric patients: a series of 55 cases in Brazil. Arch Gynecol Obstet 2009; 279: 131–7.Google Scholar
Sibai, BM, Ramadan, MK. Acute renal failure in pregnancies complicated by hemolysis, elevated liver enzymes, and low platelets. Am J Obstet Gynecol 1993; 168: 1682–7.Google Scholar
Khwaja, A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 2012; 120: c179–84.Google Scholar
Drakeley, AJ, Le Roux, PA, Anthony, J, Penny, J. Acute renal failure complicating severe preeclampsia requiring admission to an obstetric intensive care unit. Am J Obstet Gynecol 2002; 186: 253–6.CrossRefGoogle Scholar
Smaill, F, Vazquez, JC. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database Syst Rev 2015; (8): CD000490.CrossRefGoogle Scholar
Widmer, M, Gulmezoglu, AM, Mignini, L, Roganti, A. Duration of treatment for asymptomatic bacteriuria during pregnancy. Cochrane Database Syst Rev 2015; (11): CD000491.Google Scholar
Vazquez, JC, Abalos, E. Treatments for symptomatic urinary tract infections during pregnancy. Cochrane Database Syst Rev 2011; (1): CD002256.Google Scholar
Wing, DA, Fassett, MJ, Getahun, D. Acute pyelonephritis in pregnancy: an 18-year retrospective analysis. Am J Obstet Gynecol 2014; 210: 219.e1–6.Google Scholar
Hill, JB, Sheffield, JS, McIntire, DD, Wendel, GD. Acute pyelonephritis in pregnancy. Obstet Gynecol 2005; 105: 1823.Google Scholar
Foley, ME, Farquharson, R, Stronge, JM. Is screening for bacteriuria in pregnancy worthwhile? Br Med J 1987; 295: 270.Google Scholar
Jolley, JA, Kim, S, Wing, DA. Acute pyelonephritis and associated complications during pregnancy in 2006 in US hospitals. J Matern Fetal Neonatal Med 2012; 25: 2494–8.CrossRefGoogle ScholarPubMed
Schneeberger, C, Geerlings, SE, Middleton, P, Crowther, CA. Interventions for preventing recurrent urinary tract infection during pregnancy. Cochrane Database Syst Rev 2015; (7): CD009279.Google Scholar
Lumbiganon, P, Laopaiboon, M, Thinkhamrop, J. Screening and treating asymptomatic bacteriuria in pregnancy. Curr Opin Obstet Gynecol 2010; 22: 95–9.Google Scholar
D’Souza, Z, D’Souza, D. Urinary tract infection during pregnancy: dipstick urinalysis vs. culture and sensitivity. J Obstet Gynaecol 2004; 24: 22–4.Google Scholar
Jolley, JA, Wing, DA. Pyelonephritis in pregnancy: an update on treatment options for optimal outcomes. Drugs 2010; 70: 1643–55.Google Scholar
Rouse, DJ, Andrews, WW, Goldenberg, RL, Owen, J. Screening and treatment of asymptomatic bacteriuria of pregnancy to prevent pyelonephritis: a cost-effectiveness and cost-benefit analysis. Obstet Gynecol 1995; 86: 119–23.Google Scholar
Wing, DA, Rumney, PJ, Preslicka, CW, Chung, JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008; 180: 1367–72.Google Scholar
Lenke, RR, VanDorsten, JP, Schifrin, BS. Pyelonephritis in pregnancy: a prospective randomized trial to prevent recurrent disease evaluating suppressive therapy with nitrofurantoin and close surveillance. Am J Obstet Gynecol 1983; 146: 953–7.Google Scholar
Meher, S, Gibbons, N, DasGupta, R. Renal stones in pregnancy. Obstet Med 2014; 7: 103–10.Google Scholar
Semins, MJ, Matlaga, BR. Kidney stones and pregnancy. Adv Chronic Kidney Dis 2013; 20: 260–4.Google Scholar
Ross, AE, Handa, S, Lingeman, JE, Matlaga, BR. Kidney stones during pregnancy: an investigation into stone composition. Urol Res 2008; 36: 99102.Google Scholar
Swartz, MA, Lydon-Rochelle, MT, Simon, D, Wright, JL, Porter, MP. Admission for nephrolithiasis in pregnancy and risk of adverse birth outcomes. Obstet Gynecol 2007; 109: 1099–104.Google Scholar
Rosenberg, E, Sergienko, R, Abu-Ghanem, S, et al. Nephrolithiasis during pregnancy: characteristics, complications, and pregnancy outcome. World J Urol 2011; 29: 743–7.Google Scholar
Tangren JS, Powe CE, Ecker J, et al. Metabolic and hypertensive complications of pregnancy in women with nephrolithiasis. Clin J Am Soc Nephrol 2018; 13: 612–19. doi: 10.2215/CJN.12171017.Google Scholar
Banhidy, F, Acs, N, Puho, EH, Czeizel, AE. Maternal kidney stones during pregnancy and adverse birth outcomes, particularly congenital abnormalities in the offspring. Arch Gynecol Obstet 2007; 275: 481–7.Google Scholar
Butler, EL, Cox, SM, Eberts, EG, Cunningham, FG. Symptomatic nephrolithiasis complicating pregnancy. Obstet Gynecol 2000; 96: 753–6.Google Scholar
Health Protection Agency, Royal College of Radiologists, College of Radiographers. Protection of Pregnant Patients during Diagnostic Medical Exposures to Ionising Radiation. Didcot: HPA, 2009. http://www.who.int/tb/advisory_bodies/impact_measurement_taskforce/meetings/prevalence_survey/imaging_regnant_hpa.pdf (accessed March 2017).Google Scholar
Smith-Bindman, R, Aubin, C, Bailitz, J, et al. Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med 2014; 371: 1100–10.Google Scholar
Shokeir, AA, Mahran, MR, Adbulmaaboud, M. Renal colic in pregnant women: role of resistive index. Urology 2000; 55: 344–7.Google Scholar
White, WM, Johnson, EB, Zite, NB, et al. Predictive value of current imaging modalities for the detection of urolithiasis during pregnancy: a multicenter, longitudinal study. J Urol 2013; 189: 931–4.Google Scholar
Semins, MJ, Trock, BJ, Matlaga, BR. The safety of ureteroscopy during pregnancy: a systematic review and meta-analysis. J Urol 2009; 181: 139–43.Google Scholar
Mackay, EV. Pregnancy and renal disease: a ten year survey. Aust N Z J Obstet Gynecol 1963; 3: 21.Google Scholar
Youssouf, S, Hall, M, Lightstone, L, Brunskill, NJ, Carr, S. Pregnancy in a prospective cohort of women with CKD 3-5: maternal outcomes. J Am Soc Nephrol 2011; 22: 16A.Google Scholar
Imbasciati, E, Gregorini, G, Cabiddu, G, et al. Pregnancy in CKD stages 3 to 5: fetal and maternal outcomes. Am J Kidney Dis 2007; 49: 753–62.Google Scholar
Piccoli, GB, Cabiddu, G, Attini, R, et al. Pregnancy in CKD: questions and answers in a changing panorama. Best Pract Res Clin Obstet Gynaecol 2015; 29: 625–42.Google Scholar
Jungers, P, Chauveau, D, Choukroun, G, et al. Pregnancy in women with impaired renal function. Clin Nephrol 1997; 47: 281–8.Google Scholar
Basgul, A, Kavak, ZN, Sezen, D, et al. A rare case of early onset nephrotic syndrome in pregnancy. Clin Exp Obstet Gynecol 2006; 33: 127–8.Google Scholar
Fisher, KA, Ahuja, S, Luger, A, Spargo, BH, Lindheimer, MD. Nephrotic proteinuria with pre-eclampsia. Am J Obstet Gynecol 1977; 129: 643–6.CrossRefGoogle ScholarPubMed
First, MR, Ooi, BS, Jao, W, Pollak, VE. Pre-eclampsia with the nephrotic syndrome. Kidney Int 1978; 13: 166–77.Google Scholar
Imbasciati, E, Ponticelli, C. Pregnancy and renal disease: predictors for fetal and maternal outcome. Am J Nephrol 1991; 11: 353–62.CrossRefGoogle ScholarPubMed
Hall, M, Brunskill, NJ. Glomerulonephritis and the nephrotic syndrome in pregnancy. Fetal Matern Med Rev 2010; 21: 163–84.Google Scholar
Pregnancy and renal disease. Lancet 1975; 2: 801–2.Google Scholar
Nevis, IF, Reitsma, A, Dominic, A, et al. Pregnancy outcomes in women with chronic kidney disease: a systematic review. Clin J Am Soc Nephrol 2011; 6: 2587–98.Google Scholar
Franceschini, N, Savitz, DA, Kaufman, JS, Thorp, JM. Maternal urine albumin excretion and pregnancy outcome. Am J Kidney Dis 2005; 45: 1010–18.Google Scholar
Yao, T, Yao, H, Wang, H. Diagnosis and treatment of nephrotic syndrome during pregnancy. Chin Med J (Engl) 1996; 109: 471–3.Google Scholar
Brown, RA, Kemp, GJ, Walkinshaw, SA, Howse, M. Pregnancies complicated by preeclampsia and non-preeclampsia-related nephrotic range proteinuria. Obstet Med 2013; 6: 159–64.Google Scholar
De Castro I, Easterling TR, Bansal N, Jefferson JA. Nephrotic syndrome in pregnancy poses risks with both maternal and fetal complications. Kidney Int 2017; 91: 1464–72. doi: 10.1016/j.kint.2016.12.019.Google Scholar
Jones, DC, Hayslett, JP. Outcome of pregnancy in women with moderate or severe renal insufficiency. N Engl J Med 1996; 335: 226–32.Google Scholar
Bramham, K, Lightstone, L. Pre-pregnancy counseling for women with chronic kidney disease. J Nephrol 2012; 25: 450–9.Google Scholar
Li, DK, Yang, C, Andrade, S, Tavares, V, Ferber, JR. Maternal exposure to angiotensin converting enzyme inhibitors in the first trimester and risk of malformations in offspring: a retrospective cohort study. BMJ 2011; 343: d5931.Google Scholar
Tabacova, S, Little, R, Tsong, Y, Vega, A, Kimmel, CA. Adverse pregnancy outcomes associated with maternal enalapril antihypertensive treatment. Pharmacoepidemiol Drug Saf 2003; 12: 633–46.Google Scholar
Murawski, IJ, Gupta, IR. Vesicoureteric reflux and renal malformations: a developmental problem. Clin Genet 2006; 69: 105–17.Google Scholar
Mallik, M, Watson, AR. Antenatally detected urinary tract abnormalities: more detection but less action. Pediatr Nephrol 2008; 23: 897904.Google Scholar
Day, C, Hewins, P, Hildebrand, S, et al. The role of renal biopsy in women with kidney disease identified in pregnancy. Nephrol Dial Transplant 2008; 23: 201–6.Google Scholar
Fink, JC, Schwartz, SM, Benedetti, TJ, Stehman-Breen, CO. Increased risk of adverse maternal and infant outcomes among women with renal disease. Paediatr Perinat Epidemiol 1998; 12: 277–87.Google Scholar
Royal College of Obstetricians and Gynaecologists. The Investigation and Management of the Small-for-Gestational-Age Fetus, 2nd edn. Green-top Guideline No. 31. London: RCOG, 2013. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg_31.pdf (accessed March 2017).Google Scholar
Valentin, M, Muller, F, Beaujard, MP, et al. First-trimester combined screening for trisomy 21 in women with renal disease. Prenat Diagn 2015; 35: 244–8.Google Scholar
Visintin, C, Mugglestone, MA, Almerie, MQ, et al. Management of hypertensive disorders during pregnancy: summary of NICE guidance. BMJ 2010; 341: c2207.Google Scholar
Mahmoodi, BK, ten Kate, MK, Waanders, F, et al. High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome: results from a large retrospective cohort study. Circulation 2008; 117: 224–30.Google Scholar
KDIGO. Blood pressure in CKD. KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease. http://kdigo.org/home/guidelines/blood-pressure-in-ckd (accessed March 2017).Google Scholar
Magee, LA, von Dadelszen, P, Rey, E, et al. Less-tight versus tight control of hypertension in pregnancy. N Engl J Med 2015; 372: 407–17.Google Scholar
Piccoli, GB, Attini, R, Vasario, E, et al. Pregnancy and chronic kidney disease: a challenge in all CKD stages. Clin J Am Soc Nephrol 2010; 5: 844–55.Google Scholar
Kamel, H, Navi, BB, Sriram, N, et al. Risk of a thrombotic event after the 6-week postpartum period. N Engl J Med 2014; 370: 1307–15.Google Scholar
Moon, SJ, Park, HS, Kwok, SK, et al. Predictors of end-stage renal disease and recurrence of lupus activity after initiation of dialysis in patients with lupus nephritis. Clin Exp Rheumatol 2013; 31: 31–9.Google Scholar
Park, EJ, Jung, H, Hwang, J, et al. Pregnancy outcomes in patients with systemic lupus erythematosus: a retrospective review of 62 pregnancies at a single tertiary center in South Korea. Int J Rheum Dis 2014; 17: 887–97.Google Scholar
Zhao, C, Zhao, J, Huang, Y, et al. New-onset systemic lupus erythematosus during pregnancy. Clin Rheumatol 2013; 32: 815–22.Google Scholar
Moroni, G, Quaglini, S, Banfi, G, et al. Pregnancy in lupus nephritis. Am J Kidney Dis 2002; 40: 713–20.Google Scholar
Chen, TK, Gelber, AC, Witter, FR, Petri, M, Fine, DM. Renal biopsy in the management of lupus nephritis during pregnancy. Lupus 2015; 24: 147–54.Google Scholar
Borella, E, Lojacono, A, Gatto, M, et al. Predictors of maternal and fetal complications in SLE patients: a prospective study. Immunol Res 2014; 60: 170–6.Google Scholar
Jara, LJ, Medina, G, Cruz-Dominguez, P, et al. Risk factors of systemic lupus erythematosus flares during pregnancy. Immunol Res 2014; 60: 184–92.Google Scholar
Moroni, G, Ponticelli, C. Pregnancy after lupus nephritis. Lupus 2005; 14: 8994.Google Scholar
Kirshon, B, Wasserstrum, N, Willis, R, Herman, GE, McCabe, ER. Teratogenic effects of first-trimester cyclophosphamide therapy. Obstet Gynecol 1988; 72: 462–4.Google Scholar
Webster, P, Wardle, A, Bramham, K, et al. Tacrolimus is an effective treatment for lupus nephritis in pregnancy. Lupus 2014; 23: 1192–6.Google Scholar
Enns, GM, Roeder, E, Chan, RT, et al. Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype? Am J Med Genet 1999; 86: 237–41.Google Scholar
Sangle, SR, Lutalo, PM, Davies, RJ, Khamashta, MA, D’Cruz, DP. B-cell depletion therapy and pregnancy outcome in severe, refractory systemic autoimmune diseases. J Autoimmun 2013; 43: 55–9.Google Scholar
Bertsias, GK, Tektonidou, M, Amoura, Z, et al. Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis 2012; 71: 1771–82.Google Scholar
Bramham, K, Soh, MC, Nelson-Piercy, C. Pregnancy and renal outcomes in lupus nephritis: an update and guide to management. Lupus 2012; 21: 1271–83.Google Scholar
Damm, JA, Asbjornsdottir, B, Callesen, NF, et al. Diabetic nephropathy and microalbuminuria in pregnant women with type 1 and type 2 diabetes: prevalence, antihypertensive strategy, and pregnancy outcome. Diabetes Care 2013; 36: 3489–94.Google Scholar
Sato, T, Sugiyama, T, Kurakata, M, et al. Pregnancy outcomes in women with type 1 and type 2 diabetes mellitus in a retrospective multi-institutional study in Japan. Endocr J 2014; 61: 759–64.Google Scholar
Ekbom, P, Damm, P, Feldt-Rasmussen, B, et al. Pregnancy outcome in type 1 diabetic women with microalbuminuria. Diabetes Care 2001; 24: 1739–44.Google Scholar
Piccoli, GB, Clari, R, Ghiotto, S, et al. Type 1 diabetes, diabetic nephropathy, and pregnancy: a systematic review and meta-study. Rev Diabet Stud 2013; 10: 626.Google Scholar
Nielsen, LR, Damm, P, Mathiesen, ER. Improved pregnancy outcome in type 1 diabetic women with microalbuminuria or diabetic nephropathy: effect of intensified antihypertensive therapy? Diabetes Care 2009; 32: 3844.Google Scholar
Mathiesen, ER, Ringholm, L, Feldt-Rasmussen, B, Clausen, P, Damm, P. Obstetric nephrology: pregnancy in women with diabetic nephropathy–the role of antihypertensive treatment. Clin J Am Soc Nephrol 2012; 7: 2081–8.Google Scholar
Wu, M, Wang, D, Zand, L, et al. Pregnancy outcomes in autosomal dominant polycystic kidney disease: a case-control study. J Matern Fetal Neonatal Med 2016; 29: 807–12.Google Scholar
Harris, PC, Rossetti, S. Molecular diagnostics for autosomal dominant polycystic kidney disease. Nat Rev Nephrol 2010; 6: 197206.Google Scholar
Vidaeff, AC, Yeomans, ER, Ramin, SM. Pregnancy in women with renal disease. Part I: general principles. Am J Perinatol 2008; 25: 385–97.Google Scholar
Pietrzak, B, Cyganek, A, Jabiry-Zieniewicz, Z, et al. Function of the ovaries in female kidney transplant recipients. Transplant Proc 2006; 38: 180–3.Google Scholar
EBPG Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.10. Pregnancy in renal transplant recipients. Nephrol Dial Transplant 2002; 17 (Suppl 4): 50–5.Google Scholar
Armenti, VT, Radomski, JS, Moritz, MJ, et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl 2005: 69–83.Google Scholar
Deshpande, NA, James, NT, Kucirka, LM, et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant 2011; 11: 2388–404.Google Scholar
Moon, JI, Park, SG, Cheon, KO, et al. Pregnancy in renal transplant patients. Transplant Proc 2000; 32: 1869–70.Google Scholar
Piccoli GB, Cabiddu G, Attini R, et al. Outcomes of pregnancies after kidney transplantation: lessons learned from CKD. A comparison of transplanted, nontransplanted chronic kidney disease patients and low-risk pregnancies: a multicenter nationwide analysis. Transplantation 2017; 101: 2536–44. doi: 10.1097/TP.0000000000001645.Google Scholar
Mohammadi FA, Borg M, Gulyani A, McDonald SP, Jesudason S. Pregnancy outcomes and impact of pregnancy on graft function in women after kidney transplantation. Clin Transplant 2017; 31(10). doi: 10.1111/ctr.13089.Google Scholar
Sibanda, N, Briggs, JD, Davison, JM, Johnson, RJ, Rudge, CJ. Pregnancy after organ transplantation: a report from the UK Transplant pregnancy registry. Transplantation 2007; 83: 1301–7.Google Scholar
Hebert, MF, Zheng, S, Hays, K, et al. Interpreting tacrolimus concentrations during pregnancy and postpartum. Transplantation 2013; 95: 908–15.Google Scholar
Zheng, S, Easterling, TR, Umans, JG, et al. Pharmacokinetics of tacrolimus during pregnancy. Ther Drug Monit 2012; 34: 660–70.Google Scholar
Camargo, LF, Esteves, AB, Ulisses, LR, Rivelli, GG, Mazzali, M. Urinary tract infection in renal transplant recipients: incidence, risk factors, and impact on graft function. Transplant Proc 2014; 46: 1757–9.Google Scholar
Briggs, JD, Jager, K. The first year of the new ERA-EDTA Registry. Nephrol Dial Transplant 2001; 16: 1130–1.Google Scholar
Shrestha, BM, Throssell, D, McKane, W, Raftery, AT. Injury to a transplanted kidney during caesarean section: a case report. Exp Clin Transplant 2007; 5: 618–20.Google Scholar
Hoeltzenbein, M, Elefant, E, Vial, T, et al. Teratogenicity of mycophenolate confirmed in a prospective study of the European Network of Teratology Information Services. Am J Med Genet A 2012; 158A: 588–96.Google Scholar
Sifontis, NM, Coscia, LA, Constantinescu, S, et al. Pregnancy outcomes in solid organ transplant recipients with exposure to mycophenolate mofetil or sirolimus. Transplantation 2006; 82: 1698–702.Google Scholar
Saarikoski, S, Seppala, M. Immunosuppression during pregnancy: transmission of azathioprine and its metabolites from the mother to the fetus. Am J Obstet Gynecol 1973; 115: 1100–6.Google Scholar
Armenti, VT, Ahlswede, KM, Ahlswede, BA, et al. National Transplantation Pregnancy Registry: outcomes of 154 pregnancies in cyclosporine-treated female kidney transplant recipients. Transplantation 1994; 57: 502–6.Google Scholar
McKay, DB, Josephson, MA. Pregnancy in recipients of solid organs–effects on mother and child. N Engl J Med 2006; 354: 1281–93.Google Scholar
Bar Oz, B, Hackman, R, Einarson, T, Koren, G. Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis. Transplantation 2001; 71: 1051–5.Google Scholar
Hou, S. Pregnancy in chronic renal insufficiency and end-stage renal disease. Am J Kidney Dis 1999; 33: 235–52.Google Scholar
Park-Wyllie, L, Mazzotta, P, Pastuszak, A, et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 2000; 62: 385–92.Google Scholar
Jain, AB, Shapiro, R, Scantlebury, VP, et al. Pregnancy after kidney and kidney-pancreas transplantation under tacrolimus: a single center’s experience. Transplantation 2004; 77: 897902.CrossRefGoogle ScholarPubMed
Bramham, K, Chusney, G, Lee, J, Lightstone, L, Nelson-Piercy, C. Breastfeeding and tacrolimus: serial monitoring in breast-fed and bottle-fed infants. Clin J Am Soc Nephrol 2013; 8: 563–7.Google Scholar
Constantinescu, S, Pai, A, Coscia, LA, et al. Breast-feeding after transplantation. Best Pract Res Clin Obstet Gynaecol 2014; 28: 1163–73.Google Scholar
Steenkamp, R, Castledine, C, Feest, T, Fogarty, D. UK Renal Registry 13th Annual Report (December 2010): Chapter 2: UK RRT prevalence in 2009: national and centre-specific analyses. Nephron Clin Pract 2011; 119 (Suppl 2): c27–52.Google Scholar
Nadeau-Fredette, AC, Hladunewich, M, Hui, D, Keunen, J, Chan, CT. End-stage renal disease and pregnancy. Adv Chronic Kidney Dis 2013; 20: 246–52.Google Scholar
Filocamo, MT, Zanazzi, M, Li Marzi, V, et al. Sexual dysfunction in women during dialysis and after renal transplantation. J Sex Med 2009; 6: 3125–31.Google Scholar
Schwarz, A, Post, KG, Keller, F, Molzahn, M. Value of human chorionic gonadotropin measurements in blood as a pregnancy test in women on maintenance hemodialysis. Nephron 1985; 39: 341–3.Google Scholar
Shahir, AK, Briggs, N, Katsoulis, J, Levidiotis, V. An observational outcomes study from 1966–2008, examining pregnancy and neonatal outcomes from dialysed women using data from the ANZDATA Registry. Nephrology (Carlton) 2013; 18: 276–84.Google Scholar
Chan, WS, Okun, N, Kjellstrand, CM. Pregnancy in chronic dialysis: a review and analysis of the literature. Int J Artif Organs 1998; 21: 259–68.Google Scholar
Shan, HY, Rana, S, Epstein, FH, et al. Use of circulating antiangiogenic factors to differentiate other hypertensive disorders from preeclampsia in a pregnant woman on dialysis. Am J Kidney Dis 2008; 51: 1029–32.Google Scholar
Davison, JM, Nelson-Piercy, C, Kehoe, S, Baker, P. Renal Disease in Pregnancy. London: Royal College of Obstetricians and Gynaecologists, 2008.Google Scholar
Jefferys, A, Wyburn, K, Chow, J, Cleland, B, Hennessy, A. Peritoneal dialysis in pregnancy: a case series. Nephrology (Carlton) 2008; 13: 380–3.Google Scholar
Okundaye, I, Hou, S. Management of pregnancy in women undergoing continuous ambulatory peritoneal dialysis. Adv Perit Dial 1996; 12: 151–5.Google Scholar
Hladunewich, M, Hercz, AE, Keunen, J, Chan, C, Pierratos, A. Pregnancy in end stage renal disease. Semin Dial 2011; 24: 634–9.Google Scholar
Hladunewich, MA, Hou, S, Odutayo, A, et al. Intensive hemodialysis associates with improved pregnancy outcomes: a Canadian and United States cohort comparison. J Am Soc Nephrol 2014; 25: 1103–9.Google Scholar
Registration Committee of the European Dialysis and Transplant Association. Successful pregnancies in women treated by dialysis and kidney transplantation. Br J Obstet Gynaecol 1980; 87: 839–45.Google Scholar
Romao, JE, Luders, C, Kahhale, S, et al. Pregnancy in women on chronic dialysis. A single-center experience with 17 cases. Nephron 1998; 78: 416–22.Google Scholar
Jesudason, S, Grace, BS, McDonald, SP. Pregnancy outcomes according to dialysis commencing before or after conception in women with ESRD. Clin J Am Soc Nephrol 2014; 9: 143–9.Google Scholar
Barua, M, Hladunewich, M, Keunen, J, Pierratos, A, McFarlane, P, Sood, M, et al. Successful pregnancies on nocturnal home hemodialysis. Clin J Am Soc Nephrol 2008; 3: 392–6.Google Scholar
FHN Trial Group; Chertow, GM, Levin, NW, Beck, GJ, et al. In-center hemodialysis six times per week versus three times per week. N Engl J Med 2010; 363: 2287–300.Google Scholar
Chou, CY, Ting, IW, Hsieh, FJ, Lee, CN. Haemoperitoneum in a pregnant woman with peritoneal dialysis. Nephrol Dial Transplant 2006; 21: 1454–5.Google Scholar
Lew, SQ. Persistent hemoperitoneum in a pregnant patient receiving peritoneal dialysis. Perit Dial Int 2006; 26: 108–10.Google Scholar

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Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

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Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

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