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Chapter 38 - Disorders of Coagulation in Pregnancy (Content last reviewed: 11th November 2020)

from Section 5 - Late Pregnancy – Maternal Problems

Published online by Cambridge University Press:  15 November 2017

By
Cara C. Heuser  and
D. Ware Branch
Edited by
David James ,
Philip Steer ,
Carl Weiner ,
Bernard Gonik  and
Stephen Robson
David James
Affiliation:
University of Nottingham
Philip Steer
Affiliation:
Imperial College London
Carl Weiner
Affiliation:
University of Kansas
Bernard Gonik
Affiliation:
Wayne State University, Detroit
Stephen Robson
Affiliation:
University of Newcastle
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Summary

The human hemostatic system involves a number of complex and highly regulated processes. In turn, these processes are interwoven with other important systemic and cellular systems (e.g., immune, hematologic, nutritional/gastrointestinal, and cardiovascular) and are thus sensitive to myriad biologic influences and events. During states of blood vessel injury the hemostatic system must be quick, localized, and reliable. Unfortunately, there are many inherited, acquired, and physiologic conditions that can disrupt the hemostatic system and lead to suboptimal or inappropriate clot formation. The chapter focuses on thrombophilias and nonphysiologic thrombi (thrombosis not required for hemostasis) as they relate to the pregnant woman.

Type
Chapter
Information
High-Risk Pregnancy
Management Options
 , pp. 1084 - 1106
Publisher: Cambridge University Press
First published in: 2017

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