Background: The Cognitive Domains and Functional Assessment Questionnaire (CDFAQ) assess cognitive and functional decline based on the DSM-5 criteria for Neurocognitive Disorders. Its accuracy has been assessed and was translated and validated into English. The informant version (CDFAQ-IV) is a 30-item questionnaire that assesses six cognitive domains with 5 items each: Complex Attention (CA), Executive Functions (EF), Learning and

Memory (LM), Language (L), Perceptual-Motor (PM) and Social Cognition. The development of CDFAQ-IV was based on theDSM-5 cognitive domains, but its factor analysis has not been done yet.

Objectives: To perform a Confirmatory Factor Analysis of the CDFAQ-IV to assess the six-factor cognitive domain model.

Methods: Older adults and their informants were invited to participate in this study. The CDFAQ-IV was applied in 292 older adults’ informants. We used the JASP for a Confirmatory Factor Analysis based on Lavaan R Packages. The confirmatory factor analysis was chosen to manual six-factor model. This study was approved by the ethics committee of UFMG.

Results: Concerning model fitness in the confirmatory factor analysis the X2 was significant (p < .001), standardized root mean square residual (SRMR) was .059 (accepted < .08) and the goodness of fit index (GFI) .984 (accepted > .9). However, the root mean square error of approximation (RMSEA) was marginal to the accepted fitness .066 (accepted < .06) and the comparative fit index CFI was .839 under the accepted cutoff (accepted > .9).

Conclusions: The six-factor model of the showed a good fit for three parameters, marginal for one and negative for the CFI. These results point to a convergence of the questionnaire and factors the DSM-5 cognitive domains. These are still preliminary results and we aim to increase our sample to further assess the confirmatory factor analysis.

In this paper, we establish a new version of one-dimensional discrete improved Hardy’s inequality with shifts by introducing a shifting discrete Dirichlet’s Laplacian. We prove that the general discrete Hardy’s inequality as well as its variants in some special cases admit improvements. Further, it is proved that two-variable discrete $p$-Hardy inequality can also be improved via improved discrete $p$-Hardy inequality in one dimension. The result is also extended to the multivariable cases.

Ascaridoidea (Nematoda) is a widespread superfamily of nematodes that comprises gastrointestinal parasites from all major groups of vertebrates. Although this taxon probably emerged in the Carboniferous, its Brazilian fossil record includes mostly eggs, found in ancient remains, collected in paleontological and archeological sites from the Mesozoic and Cenozoic Eras. The Tremembé Formation (Oligocene of the Taubaté Basin) has become an important source for paleoparasitological studies in avian coprolites during the third decade of the 21st century, with reports of eggs only at only a single cell stage, of embryonic development. Here we present the first egg of Ascaridoidea preserved containing morula, from a bird coprolite recovered from the shales of the Tremembé Formation. Three coprolites, from the outcrop of Aligra Comércio de Argila S/A, Taubaté municipality (State of São Paulo), were rehydrated and subjected to spontaneous sedimentation. Based on morphological and morphometric features and diet and zoopaleontological context, the trace fossils were assigned to piscivorous birds. The egg found showed morphological characteristics typical of Ascaridoidea: namely spherical form, ornamented, and somewhat thick shell. Moreover, this superfamily includes several taxa that infect piscivorous birds and fish in heteroxenous life cycles and produce eggs with similar features as the egg found in the present study. The paleoparasitological information associated with the paleofaunistic diversity of birds and fish from the Tremembé Formation, reveal that the ancient Brazilian paleoenvironments provided subsidies for the rise and success of nematodes infecting these animals during the Paleogene.

Silvopastoral systems (SPSs) constitute a modality of agroforestry systems in which trees or shrubs, pastures and animals mutually grow, interacting with the environment, and providing several ecosystem services. This review aims to comprehensively discuss the ecosystem services provided by SPSs in different countries, highlighting the diverse ways these systems can contribute to human well-being and environmental sustainability, also emphasizing the importance of management strategies, the differences among systems and the main shortcomings and challenges to optimizing ecosystem service delivery from SPSs. The review focused on global studies, mainly those published between 2010 and 2024, directly relevant to the topic. We used Google Scholar, Scopus and Web of Science databases for literature screening. SPSs have demonstrated worldwide potential to enhance human food and forage production, nutrient cycling, soil fertility, biological nitrogen fixation, carbon sequestration, greenhouse gas mitigation, erosion control, microclimate regulation, pollination, control of pests and diseases, biodiversity, residue absorption, water quality, spiritual enrichment, recreation and aesthetic experiences. However, most ecosystem services provided by SPSs depend on climate conditions, soil type, choice of species, system design and management practices to ensure that such benefits are not provided at the cost of other important services. Interaction among components is a major challenge for system management and evaluations. Adopting SPSs has the potential to promote sustainable agriculture. Long-term studies are needed to elucidate the implications of multiple interactions within the system and their impact on ecosystem service delivery. Public policies, including evaluating ecosystem services, should be developed to promote the adoption of SPSs.

We present the fourth data release (DR4) of the SkyMapper Southern Survey (SMSS), the last major step in our hemispheric survey with six optical filters: u, v, g, r, i, z. SMSS DR4 covers 26 000 deg$^{2}$ from over 400 000 images acquired by the 1.3 m SkyMapper telescope between 2014-03 and 2021-09. The 6-band sky coverage extends from the South Celestial Pole to $\delta=+16^{\circ}$, with some images reaching $\delta\sim +28^{\circ}$. In contrast to previous DRs, we include all good-quality images from the facility taken during that time span, not only those explicitly taken for the public Survey. From the image dataset, we produce a catalogue of over 15 billion detections made from $\sim$700 million unique astrophysical objects. The typical 10$\sigma$ depths for each field range between 18.5 and 20.5 mag, depending on the filter, but certain sky regions include longer exposures that reach as deep as 22 mag in some filters. As with previous SMSS catalogues, we have cross-matched with a host of other imaging and spectroscopic datasets to facilitate additional science outcomes. SMSS DR4 is now available to the worldwide astronomical community.

The occurrence of dyslipidaemia, which is an established risk factor for cardiovascular diseases, has been attributed to multiple factors including genetic and environmental factors. We used a genetic risk score (GRS) to assess the interactions between genetic variants and dietary factors on lipid-related traits in a cross-sectional study of 190 Brazilians (mean age: 21 ± 2 years). Dietary intake was assessed by a trained nutritionist using three 24-h dietary recalls. The high GRS was significantly associated with increased concentration of TAG (beta = 0·10 mg/dl, 95 % CI 0·05–0·16; P < 0·001), LDL-cholesterol (beta = 0·07 mg/dl, 95 % CI 0·04, 0·11; P < 0·0001), total cholesterol (beta = 0·05 mg/dl, 95 % CI: 0·03, 0·07; P < 0·0001) and the ratio of TAG to HDL-cholesterol (beta = 0·09 mg/dl, 95 % CI: 0·03, 0·15; P = 0·002). Significant interactions were found between the high GRS and total fat intake on TAG:HDL-cholesterol ratio (Pinteraction = 0·03) and between the high GRS and SFA intake on TAG:HDL-cholesterol ratio (Pinteraction = 0·03). A high intake of total fat (>31·5 % of energy) and SFA (>8·6 % of energy) was associated with higher TAG:HDL-cholesterol ratio in individuals with the high GRS (beta = 0·14, 95 % CI: 0·06, 0·23; P < 0·001 for total fat intake; beta = 0·13, 95 % CI: 0·05, 0·22; P = 0·003 for SFA intake). Our study provides evidence that the genetic risk of high TAG:HDL-cholesterol ratio might be modulated by dietary fat intake in Brazilians, and these individuals might benefit from limiting their intake of total fat and SFA.

Background: Meningiomas are the most common intracranial tumor with surgery, dural margin treatment, and radiotherapy as cornerstones of therapy. Response to treatment continues to be highly heterogeneous even across tumors of the same grade. Methods: Using a cohort of 2490 meningiomas in addition to 100 cases from the prospective RTOG-0539 phase II clinical trial, we define molecular biomarkers of response across multiple different, recently defined molecular classifications and use propensity score matching to mimic a randomized controlled trial to evaluate the role of extent of resection, dural marginal resection, and adjuvant radiotherapy on clinical outcome. Results: Gross tumor resection led to improved progression-free-survival (PFS) across all molecular groups (MG) and improved overall survival in proliferative meningiomas (HR 0.52, 95%CI 0.30-0.93). Dural margin treatment (Simpson grade 1/2) improved PFS versus complete tumor removal alone (Simpson 3). MG reliably predicted response to radiotherapy, including in the RTOG-0539 cohort. A molecular model developed using clinical trial cases discriminated response to radiotherapy better than standard of care grading in multiple cohorts (ΔAUC 0.12, 95%CI 0.10-0.14). Conclusions: We elucidate biological and molecular classifications of meningioma that influence response to surgery and radiotherapy in addition to introducing a novel molecular-based prediction model of response to radiation to guide treatment decisions.

Sucrose yield in sugarcane is a complex process regulated by both environmental and endogenous factors. However, the metabolic balance driving vegetative growth and sucrose accumulation remains poorly understood. Herein, we carried out a comprehensive assessment of carbohydrate dynamics throughout the crop cycle in two sugarcane varieties varying in biomass production, evaluating the carbon metabolism in both leaves and stalks. Our data revealed that the decline in photosynthetic rates during sugarcane maturation is associated not only to accumulation of sugars in leaves but also due to stomatal and non-stomatal limitations. We found that metabolic processes in leaves and stalks were intrinsically linked. While IACSP94-2094 had higher stalk sucrose concentration than IACSP95-5000, this latter produced more biomass. Compared to IACSP95-5000, IACSP94-2094 showed higher sucrose phosphate synthase (SPS) activity in leaves and stalks, along with lower soluble acid invertase (SAI) activity in leaves during the maximum growth stage. Interestingly, IACSP94-2094 also exhibited higher stalk SPS activity and lower stalk SAI activity than IACSP95-5000 during maturation. High biomass production by IACSP95-5000 was associated with higher sucrose synthase (SuSy) and SAI activity in leaves and higher SuSy and soluble neutral invertase (SNI) activity in stalks when compared to IACSP94-2094 during the maximum growth. Despite the contrasting strategies, both varieties displayed similar total sucrose yield, a balance between sucrose concentration and biomass production. This phenomenon implies the presence of a compensatory mechanism in sugarcane, with high biomass production compensating low sucrose accumulation and vice versa.

We published a series of papers regarding the oldest turritellids, naticids, their paleoecological interaction, and gastropod biozonation, which are of Oxfordian in age, from the Jhura pond section, Kutch, western India. Recently, an Oxfordian age was challenged by Fürsich et al. (2023) and they argued for a Cenozoic age. The authors reproduced a local geological map based on regional data where the Jhura pond section sediments were overlying the Bhuj Formation. In the original regional data, there was no Bhuj Formation and the introduction of the Bhuj Formation served to show that Jhura pond section sediments were “allochthonous”. Other lines of argument against our conclusions (e.g., identification of associated bivalve fauna, foraminiferal assemblage, and geological context) were brought forward. There were additional inconsistencies, such as the reworking of Oxfordian fossils, in their comment/opinion pieces. The only hard evidence was the report of a microfaunal assemblage, but the taxa were identified at the generic level and most of the genera appear in the Jurassic or even earlier.

Here we provide detailed and concrete evidence explaining features at the Jhura pond section, such as the subvertical nature of the beds, the ooid-bearing lithologies, the presence of various Oxfordian fossils, the difference in turritellids, naticid assemblages, and differences in the diversity curves between the present beds and the lower Miocene Chhasra Formation of Kutch. Detailed paleoecological analyses (both gastropods and bivalves) speak for two paleocommunities. We, therefore, reiterate that the present Jhura pond section sediments are Oxfordian in age and validate all the interpretations and conclusions that we have made in our previous papers.

Velocity gradient tensor, $A_{ij}\equiv \partial u_i/\partial x_j$, in a turbulence flow field is modelled by separating the treatment of intermittent magnitude ($A = \sqrt {A_{ij}A_{ij}}$) from that of the more universal normalised velocity gradient tensor, $b_{ij} \equiv A_{ij}/A$. The boundedness and compactness of the $b_{ij}$-space along with its universal dynamics allow for the development of models that are reasonably insensitive to Reynolds number. The near-lognormality of the magnitude $A$ is then exploited to derive a model based on a modified Ornstein–Uhlenbeck process. These models are developed using data-driven strategies employing high-fidelity forced isotropic turbulence data sets. A posteriori model results agree well with direct numerical simulation data over a wide range of velocity-gradient features and Reynolds numbers.

Healthcare workers (HCWs) were at increased risk for mental health problems during the COVID-19 pandemic, with prior data suggesting women may be particularly vulnerable. Our global mental health study aimed to examine factors associated with gender differences in psychological distress and depressive symptoms among HCWs during COVID-19. Across 22 countries in South America, Europe, Asia and Africa, 32,410 HCWs participated in the COVID-19 HEalth caRe wOrkErS (HEROES) study between March 2020 and February 2021. They completed the General Health Questionnaire-12, the Patient Health Questionnaire-9 and questions about pandemic-relevant exposures. Consistently across countries, women reported elevated mental health problems compared to men. Women also reported increased COVID-19-relevant stressors, including insufficient personal protective equipment and less support from colleagues, while men reported increased contact with COVID-19 patients. At the country level, HCWs in countries with higher gender inequality reported less mental health problems. Higher COVID-19 mortality rates were associated with increased psychological distress merely among women. Our findings suggest that among HCWs, women may have been disproportionately exposed to COVID-19-relevant stressors at the individual and country level. This highlights the importance of considering gender in emergency response efforts to safeguard women’s well-being and ensure healthcare system preparedness during future public health crises.

Two analogous inorganic-organic hybrids with a phyllosilicate-like structure SILMg1 and SILMg2, containing 3-aminopropyl- and N-propylethylenediaminetrimethoxysilane were synthesized through a sol-gel process. These hybrids adsorbed divalent cations of cobalt, nickel, copper, and zinc from aqueous solution to give the effectiveness of adsorption capacities in the sequence Cu2+ > Zn2+ > Ni2+ > Co2+. SILMg1 has a higher capacity of adsorption than SILMg2. Elemental analysis, X-ray diffractometry, thermal analysis, infrared and nuclear magnetic resonance spectroscopies, and energy dispersive system microscopy characterized all hybrids. The proposed adsorption mechanism involves dissolution of the precursor matrix, formation of a phyllosilicate around the adsorbed ion, and a complexation of the cation by the amino-pendant groups in the interlayer. These new phyllosilicates are more crystalline than the original hybrids. The adsorption of Co2+ increases the interlayer distance to maximum values of 1.81 and 2.24 Å for SILMg1 and SILMg2, respectively. Thermal analysis data showed a decrease of thermal stability with cation adsorption. Si-O-Si groups were detected by infrared spectroscopy in all hybrids and a band at 1384 cm-1 was assigned to the nitrate counter anion, which indicates the participation of this ion in the sphere of coordination of the interlayer complexes. The photomicrographs obtained by scanning electron microscopy showed the organized distribution of the sheet structure for these synthesized phyllosilicates.

Many soils developed from volcanic rocks in southern Brazil exhibit spontaneous magnetization caused by the presence of fine-grained maghemite (γ-Fe2O3), but few attempts were made to quantify or characterize this important soil component. To that end, clays were separated from freely drained soils derived from acid (≥63% SiO2), intermediate (54–62% SiO2), and basic (≤53% SiO2) igneous rocks produced by the Paraná flood volcanism. The sample set included soils with a wide range of pedogenic development on different landscape positions. The Fe oxide mineralogy of these samples was examined by using a combination of selective dissolution, magnetic susceptibility, and X-ray diffraction (XRD) techniques. Hematite and maghemite were the primary Fe oxides in mature soils (Oxisols, Ultisols, and Alfisols) developed from basic rocks; whereas goethite was dominant in all other soils, especially those formed from acid-intermediate rocks. The association of maghemite with basic rock materials suggests that it was primarily formed by oxidation of lithogenic magnetite. A strong, positive correlation (R2 = 0.89) was obtained between mass specific magnetic susceptibility (χ) of the clay fractions and maghemite contents estimated by XRD. Either method could be used for quantitative analyses, but χ was more sensitive than XRD at low maghemite concentrations (<2 wt. %). The clay-sized maghem-ites were superparamagnetic with an estimated value for the mass specific magnetic susceptibility (χlf) value of 91,000 × 10−8 m3 kg−1 and frequency dependent variations of 10–15%. The maghemites also had low unit cell constants, which, if attributed entirely to replacement of Fe by Al, would correlate with Al substitutions in the range of 5–16 mole %. Selective dissolution of the soil maghemites was achieved by treatment of Fe oxide concentrates with 1.8 M H2SO4 at 75°C for 2 h.

Magnetic fractionation, chemical, and structural analyses prove that alteration of ilmenite from Manavalakurichi deposit extends only up to the formation of pseudorutile with traces of rutile. The data indicate that ferrous to ferric iron transformation, ferric iron oxide formation, and iron removal contribute to the alteration sequence. The first two highly magnetic fractions are not unaltered ilmenite. A reduction in ilmenite unit cell volume indicates the ferrous-ferric conversion occurred during alteration.