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The East Kunlun Orogen (EKO) is the NW part of the Central China Orogenic Belt, which records the evolutionary history of the Proto- and Palaeo-Tethys Oceans from the Cambrian to the Triassic. An Early Palaeozoic eclogite belt has been recognized in recent years, which extends discontinuously for ∼500 km as three eclogite-bearing terranes. In this study, we report an integrated study of zircon grains from mica-schists accompanying the eclogites, in terms of mineral inclusions, U–Pb age systematics and P–T conditions. The presence of coesite is identified, as inclusions within the metamorphic domain of zircons, which provides unambiguous evidence for subducted terrigenous clastic rocks of the Proto-Tethys Ocean exhumed from coesite-forming depths. U–Pb dating of the metamorphic zircons yields a concordia age of 426.5 ± 0.88 Ma, which is likely to be the time of ultrahigh-pressure metamorphism in the Kehete terrane. P–T calculations suggest that metapelite may have experienced a clockwise P–T path with peak P/T conditions of 685 ± 41 °C and >28 kbar, and equilibrated at 482–566 °C and 5.6–8.9 kbar during subsequent exhumation. The high-pressure – ultrahigh-pressure (HP-UHP) metamorphic belt within the EKO may have formed by collision between the Qaidam Block and the South Kunlun Block, as a consequence of the closure of the Proto-Tethys Ocean.
Glyphodes pyloalis Walker (Lepidoptera: Pyralididae) is a common pest in sericulture and has developed resistance to different insecticides. However, the mechanisms involved in insecticide resistance of G. pyloalis are poorly understood. Here, we present the first whole-transcriptome analysis of differential expression genes in insecticide-resistant and susceptible G. pyloalis. Clustering and enrichment analysis of DEGs revealed several biological pathways and enriched Gene Ontology terms were related to detoxification or insecticide resistance. Genes involved in insecticide metabolic processes, including cytochrome P450, glutathione S-transferases and carboxylesterase, were identified in the larval midgut of G. pyloalis. Among them, CYP324A19, CYP304F17, CYP6AW1, CYP6AB10, GSTs5, and AChE-like were significantly increased after propoxur treatment, while CYP324A19, CCE001c, and AChE-like were significantly induced by phoxim, suggesting that these genes were involved in insecticide metabolism. Furthermore, the sequence variation analysis identified 21 single nucleotide polymorphisms within CYP9A20, CYP6AB47, and CYP6AW1. Our findings reveal many candidate genes related to insecticide resistance of G. pyloalis. These results provide novel insights into insecticide resistance and facilitate the development of insecticides with greater specificity to G. pyloalis.
Residents of Hong Kong have undergone a dietary transition from a traditional Chinese diet that is high in seafood to a more Western diet. This may have affected the nutritional composition of breast milk of Hong Kong mothers. The present study aims to investigate the relationship between the dietary pattern and the fatty acid profile of the breast milk of lactating women in Hong Kong. Seventy-three volunteering healthy Hong Kong lactating mothers participated in the study. Their dietary intakes were assessed by using a 3-d dietary record and FFQ. The mean n-3 fatty acid levels were approximately 0·4 % (EPA) and 0·9 % (DHA) of total fatty acids in the breast milk of lactating mothers who had exclusively breastfed their infants aged 2–6 months. Maternal dietary intakes of n-3 fatty acids were positively associated with their levels in the breast milk. The levels of maternal intakes of freshwater and saltwater fish, especially the consumption of salmon, croaker and mandarin, were significantly correlated with the content of DHA in breast milk. The present study is among the very few in the literature to determine the fatty acid profile of breast milk in Hong Kong populations and verify certain dietary factors that influence this profile. High levels of n-3 PUFA, especially DHA, were observed in the breast milk of Hong Kong lactating women. The findings may serve as a dietary reference for lactating mothers to optimise the fatty acid profile of their breast milk.
Annexin A2 (ANXA2) is reported to be associated with cancer development. To investigate the roles ANXA2 plays during the development of cancer, the RNAi method was used to inhibit the ANXA2 expression in caco2 (human colorectal cancer cell line) and SMMC7721 (human hepatocarcinoma cell line) cells. The results showed that when the expression of ANXA2 was efficiently inhibited, the growth and motility of both cell lines were significantly decreased, and the development of the motility relevant microstructures, such as pseudopodia, filopodia, and the polymerization of microfilaments and microtubules were obviously inhibited. The cancer cell apoptosis was enhanced without obvious significance. The possible regulating pathway in the process was also predicted and discussed. Our results suggested that ANXA2 plays important roles in maintaining the malignancy of colorectal and hepatic cancer by enhancing the cell proliferation, motility, and development of the motility associated microstructures of cancer cells based on a possible complicated signal pathway.
Major depressive disorder (MDD) is highly heterogeneous and can be classified as treatment-resistant depression (TRD) or antidepressant-responsive depression (non-TRD) based on patients' responses to antidepressant treatment. Methods for distinguishing between TRD and non-TRD are critical clinical concerns. Deficits of cortical inhibition (CI) have been reported to play an influential role in the pathophysiology of MDD. Whether TRD patients' CI is more impaired than that of non-TRD patients remains unclear.
Paired-pulse transcranial magnetic stimulation (ppTMS) was used to measure cortical inhibitory function including GABAA- and GABAB-receptor-related CI and cortical excitatory function including glutamate-receptor-related intracortical facilitation (ICF). We recruited 36 healthy controls (HC) and 36 patients with MDD (non-TRD, n = 16; TRD, n = 20). All participants received evaluations for depression severity and ppTMS examinations. Non-TRD patients received an additional ppTMS examination after 3 months of treatment with the SSRI escitalopram.
Patients with TRD exhibited reduced short-interval intracortical inhibition (SICI) and long-interval intracortical inhibition (LICI), as shown by abnormally higher estimates, than those with non-TRD or HC (F = 11.030, p < 0.001; F = 10.309, p < 0.001, respectively). After an adequate trial of escitalopram treatment, the LICI of non-TRD reduced significantly (t = − 3.628, p < 0.001), whereas the ICF remained lower than that of HC and showed no difference from pretreatment non-TRD.
TRD was characterized by relatively reduced CI, including both GABAA- and GABAB-receptor-mediated neurons while non-TRD preserved partial CI. In non-TRD, SSRIs may mainly modulate GABAB-receptor-related LICI. Our findings revealed distinguishable features of CI in antidepressant-resistant and responsive major depression.
We present a high-peak-power, near-infrared laser system based on optical parametric chirped pulse amplification pumped by a home-built picosecond pumping laser, which can generate over 40 mJ energy at 1450 nm center wavelength and operate at 100 Hz repetition rate. Subsequently, the chirped laser pulses are compressed down to 60 fs with 26.5 mJ energy, corresponding to a peak power of 0.44 TW. This high-energy, long-wavelength laser source is highly suitable for driving various nonlinear optical phenomena, such as high-order harmonic generation and high-flux coherent extreme ultraviolet/soft X-ray radiation.
Thermocapillary convection has always been one of the most important research topics in microgravity fluid physics. A space experimental study on the thermocapillary convection in an open annular liquid pool – a typical thermocapillary flow system – has been conducted on the SJ-10 satellite of China. This space experiment has observed the spatial temperature distribution of the liquid free surface using an infrared thermal imager, obtained the flow pattern transition process, analysed the oscillation characteristics and revealed the instability mechanism of themocapillary convection. The shape effects on the flow instability are researched by changing the volume ratio, Vr, which denotes the ratio of the liquid volume to the volume of the cylindrical gap between the walls. The volume ratio effect has been focused on for the first time. For a certain volume ratio, the flow pattern would transform from the steady state to the oscillation state accompanied by directional propagating hydrothermal waves with increasing temperature difference. In addition, the significant influences of the volume ratio on the critical conditions and wavenumber selection have been analysed in detail.
The second home-made single stage accelerator mass spectrometer (SSAMS) system dedicated to radiocarbon (14C) measurements was built after the first SSAMS system was moved to Guangxi Normal University. With some improvements to the second SSAMS system, the performance has been improved. With the conditions of total ion energy of 200KeV, ions charge states of 1+ and helium as stripper gas, 14C measurements with precision of 0.5% and a background level of 0.5 pMC were achieved. Details of the system and the experimental performance are given here.
Coupled with the social practice of female hypergamy, the male surplus within the never-married population means that today's Chinese marriage market is extremely tight in particular for men from a rural background and the least privileged socio-economic categories. Drawing on quantitative data from a survey conducted in 2014–2015, this article sheds light on the situation of single men who are past prime marriage age in three rural districts of Shaanxi particularly affected by this phenomenon. It compares single men's characteristics to those of their married counterparts and offers insights into the heterogeneity of single men with the aim of challenging some commonly accepted assumptions about bachelorhood in rural China. Results suggest a strong internalization of the various characteristics, centred on being able to offer social mobility to a potential wife, that a man is expected to have to be attractive to women in a context where women have more choice in mate selection. We conclude that mate selection is highly marked by class, social norms, social interactions, health, generation and age, and requires the mobilization of certain amounts of individual, social and economic resources. Unwanted bachelorhood would thus be better understood using an intersectional approach rather than mainly in numeric terms.
FM-to-AM (frequency modulation-to-amplitude modulation) conversion caused by nonuniform spectral transmission of broadband beam is harmful to high-power laser facility. Smoothing by spectral dispersion (SSD) beam is a special broadband beam for its monochromatic feature at the given time and space on the near field. The traditional method which uses the optical spectral transfer function as filters cannot accurately describe its AM characteristics. This paper presents the theoretical analysis of the etalon effect for SSD beam. With a low-order approximation, the analytic model of the temporal shape of SSD beam is obtained for the first time, which gives the detailed AM characteristics at local and integral aspects, such as the variation of ripples width and amplitude in general situation. We also analyze the FM-to-AM conversion on the focal plane; in the focusing process, the lens simply acts as an integrator to smooth the AM of SSD beam. Because AM control is necessary for the near field to avoid optics damage and for the far field to ensure an optimal interaction of laser–target, our investigations could provide some important phenomena and rules for pulse shape control.
Laves phase plays a positive role in improving the strength of high-entropy alloys (HEAs); Nb and Ti elements have potential to promote Laves phase formation in some HEAs. For improving the strength of the face-centered cubic (FCC) CoCrFeMnNi HEA, a series of (CoCrFeMnNi)100−xNbx (atomic ratio: x = 0, 4, 8, 12, 16) and (CoCrFeMnNi)100−xTix (atomic ratio: x = 0, 2, 4, 6, 8, 12) HEAs were prepared by melting. The effects of Nb and Ti on the microstructure evolution and compressive properties of the CoCrFeMnNi HEAs were investigated. For (CoCrFeMnNi)100−xNbx HEAs, the second-phase (Laves and σ phase) volume fraction increased from 0 to 42%. The yield strength also increased gradually from 202 to 1010 MPa. However, the fracture strain decreased from 60% (no fracture) to 12% with increasing Nb content. For (CoCrFeMnNi)100−xTix HEAs, the yield strength increased from 202 to 1322 MPa. The Laves phase volume fraction also increased from 0 to 27%. However, the fracture strain decreased from 60% (no fracture) to 7.5% with increasing Ti content. Addition of Nb and Ti has a good effect on improving the strength of FCC CoCrFeMnNi HEA.
Research suggests an association between metabolic disorders, such as type 2 diabetes mellitus (T2DM), and schizophrenia. However, the risk of metabolic disorders in the unaffected siblings of patients with schizophrenia remains unclear.
Using the Taiwan National Health Insurance Research Database, 3135 unaffected siblings of schizophrenia probands and 12,540 age-/sex-matched control subjects were included and followed up to the end of 2011. Individuals who developed metabolic disorders during the follow-up period were identified.
The unaffected siblings of schizophrenia probands had a higher prevalence of T2DM (3.4% vs. 2.6%, p = 0.010) than the controls. Logistic regression analyses with the adjustment of demographic data revealed that the unaffected siblings of patients with schizophrenia were more likely to develop T2DM (odds ratio [OR]: 1.39, 95% confidence interval [CI]: 1.10–1.75) later in life compared with the control group. Moreover, only female siblings of schizophrenia probands had an increased risk of hypertension (OR: 1.47, 95% CI: 1.07–2.01) during the follow-up compared with the controls.
The unaffected siblings, especially sisters, of schizophrenia probands had a higher prevalence of T2DM and hypertension compared with the controls. Our study revealed a familial link between schizophrenia and T2DM in a large sample. Additional studies are required to investigate the shared pathophysiology of schizophrenia and T2DM.
Public interest law organizations (PILOs) are important institutions for providing access to justice in the United States. How have political, economic, and institutional factors shaped PILOs? How do PILOs vary in the services they offer and in their geographical location relative to poverty and population in the United States? This article investigates these questions by combining original survey data from a representative sample of public interest law organizations with GIS data on population and poverty. We find that the presence of a PILO is positively related to political progressiveness and population at the county level, but negatively related to the concentration of poverty. Our analysis reveals a two-tier system of public interest representation in which national organizations engage in a variety of social change strategies, whereas local and regional organizations utilize more limited strategies and depend more on governmental funding. These patterns have implications for access to justice in the United States today.
How are international law firms faring in China? Drawing on 2013 data, this article presents the first comprehensive overview of the field, including information about the global mix of players and variation in market niche. Three variables—years present in China, global strategy, and level of localization—help explain why some China practices grow bigger than others. Overall, however, there is a great deal of convergence on one business model: an outpost office with a median size of eleven lawyers responsible for under 5 percent of worldwide revenue. The common experience of stagnation following market entry illustrates the strength of hype, the constraints of partnership, and the persistent power of the Chinese state to shape the legal services market. At the same time, the rarity of market exit reflects perceptions that a China presence is a valuable symbol of global commitment and a worthwhile bet on future growth.
TRIM28/KAP1/TIF1β was identified as a universal transcriptional co-repressor and is critical for regulating post-fertilization methylation reprogramming in preimplantation embryos. In this study, three siRNAs (si647, si742, and si1153) were designed to target the TRIM28 mRNA sequence. After transfection of the mixture of the three siRNA (siMix) into bovine fibroblast cells, the most effective one for TRIM28 knockdown was selected. By injecting RNAi directed against TRIM28 mRNA, we found that TRIM28 knockdown in oocytes had the most effect on the H19 gene, in which differentially methylated region (DMR) methylation was almost completely absent at the 2-cell stage (1.4%), while control embryos showed 74% methylation. In addition, global H3K9me3 levels at the 2-cell stage were significantly higher in the in vitro fertilization (IVF) group than in the TRIM28 knockdown group (P<0.05). We further show that TRIM28 is highly expressed during oocyte maturation and reaches peak levels at the 2-cell stage. In contrast, at this stage, TRIM28 expression in somatic cell nuclear transfer (SCNT) embryos decreased significantly (P<0.05), suggesting that Trim28 transcripts are lost during SCNT. TRIM28 is required for the maintenance of methylation imprints in bovine preimplantation embryos, and the loss of TRIM28 during SCNT may contribute to the unfaithful maintenance of imprints in cloned embryos.
Bipolar disorder is a highly heritable mental illness that transmits intergeneratively. Previous studies supported that first-degree relatives (FDRs), such as parents, offspring, and siblings, of patients with bipolar disorder, had a higher risk of bipolar disorder. However, whether FDRs of bipolar patients have an increased risk of schizophrenia, major depressive disorder (MDD), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD) remains unclear.
Among the entire population in Taiwan, 87 639 patients with bipolar disorder and 188 290 FDRs of patients with bipolar disorder were identified in our study. The relative risks (RRs) of major psychiatric disorders were assessed among FDRs of patients with bipolar disorder.
FDRs of patients with bipolar disorder were more likely to have a higher risk of major psychiatric disorders, including bipolar disorder (RR 6.12, 95% confidence interval (CI) 5.95–6.30), MDD (RR 2.89, 95% CI 2.82–2.96), schizophrenia (RR 2.64, 95% CI 2.55–2.73), ADHD (RR 2.21, 95% CI 2.13–2.30), and ASD (RR 2.10, 95% CI 1.92–2.29), than the total population did. These increased risks for major psychiatric disorders were consistent across different familial kinships, such as parents, offspring, siblings, and twins. A dose-dependent relationship was also found between risk of each major psychiatric disorder and numbers of bipolar patients.
Our study was the first study to support the familial coaggregation of bipolar disorder with other major psychiatric disorders, including schizophrenia, MDD, ADHD, and ASD, in a Taiwanese (non-Caucasian) population. Given the elevated risks of major psychiatric disorders, the public health government should pay more attention to the mental health of FDRs of patients with bipolar disorder.
The formation of low-angle grain boundaries (LABs) in the rejoined platforms of a Ni-based single crystal superalloy under different directional solidification rates was investigated by the experimental investigation and the ProCAST simulation. The results showed that the growth morphology and orientation evolution of dendrites in the platforms were different under the withdrawal rates in the range of 60–100 μm/s and then resulted in different types of LABs. At lower withdrawal rates, the longitudinal LABs were common in the rejoined platforms. Both the sliver defects and the orientation deviation of original primary dendrites from two independent growth paths could cause the longitudinal LABs in the platforms. At higher withdrawal rates, the dendrite growth patterns were more complex and the secondary branches with lateral growth tended to deviate from their original orientation, eventually leading to the formation of some transverse LABs. Finally, some suggestions to prevent the formation of different LABs are provided.