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Antenna-pattern measurements obtained from a double-metal supra-terahertz-frequency (supra-THz) quantum cascade laser (QCL) are presented. The QCL is mounted within a mechanically micro-machined waveguide cavity containing dual diagonal feedhorns. Operating in continuous-wave mode at 3.5 THz, and at an ambient temperature of ~60 K, QCL emission has been directed via the feedhorns to a supra-THz detector mounted on a multi-axis linear scanner. Comparison of simulated and measured far-field antenna patterns shows an excellent degree of correlation between beamwidth (full-width-half-maximum) and sidelobe content and a very substantial improvement when compared with unmounted devices. Additionally, a single output has been used to successfully illuminate and demonstrate an optical breadboard arrangement associated with a future supra-THz Earth observation space-borne payload. Our novel device has therefore provided a valuable demonstration of the effectiveness of supra-THz diagonal feedhorns and QCL devices for future space-borne ultra-high-frequency Earth-observing heterodyne radiometers.
We present a workflow to track icebergs in proglacial fjords using oblique time-lapse photos and the Lucas-Kanade optical flow algorithm. We employ the workflow at LeConte Bay, Alaska, where we ran five time-lapse cameras between April 2016 and September 2017, capturing more than 400 000 photos at frame rates of 0.5–4.0 min−1. Hourly to daily average velocity fields in map coordinates illustrate dynamic currents in the bay, with dominant downfjord velocities (exceeding 0.5 m s−1 intermittently) and several eddies. Comparisons with simultaneous Acoustic Doppler Current Profiler (ADCP) measurements yield best agreement for the uppermost ADCP levels (~ 12 m and above), in line with prevalent small icebergs that trace near-surface currents. Tracking results from multiple cameras compare favorably, although cameras with lower frame rates (0.5 min−1) tend to underestimate high flow speeds. Tests to determine requisite temporal and spatial image resolution confirm the importance of high image frame rates, while spatial resolution is of secondary importance. Application of our procedure to other fjords will be successful if iceberg concentrations are high enough and if the camera frame rates are sufficiently rapid (at least 1 min−1 for conditions similar to LeConte Bay).
Microdiffraction is defined as the x-ray diffraction analysis performed on small samples or small areas of large samples. Since smallness is a relative term, micro diffraction is considered the technique of choice when samples are too small for the optics and precision of conventional instrumentation.
Objectives: A rich body of literature has established the role of body image distortion and dissatisfaction in the development and maintenance of eating disorders. However, many of the currently used techniques require explicit comparison of the person’s body to an external stimulus. As the body schema is a largely unconscious construct, explicit comparison tasks may reflect a proxy, rather than the body schema itself. Methods: Here we use an implicit mental motor imagery (MMI) task to interrogate the body schema in healthy control participants (N=40) and participants at a residential eating disorder treatment center (N=42). By comparing the time it takes to imagine making a movement along a part of the body to the time it takes to actually make the same movement, we were able to assess participants’ mental image of their body (i.e., body schema). Results: We found that participants with eating disorders, but not healthy controls, exhibited distortions of the body schema such that they believed their abdomen, buttocks, and thighs to be larger than they really are. Additionally, the MMI task used here provided information above and beyond traditional self-report measures (i.e., Body Shape Questionnaire). Together the MMI task and traditional measures provide the most information. Conclusions: Findings using the novel MMI task are in line with the literature; participants with eating disorders consider themselves to be larger than they truly are. Taken together, results of this study suggest that MMI tasks provide complementary information to traditional self-report measures. (JINS, 2018, 22, 000–000)
Purpose: We identified key clinicopathologic features of brain metastasis (BM) patients who are long-term survivors (LTS). Methods: We screened a prospective database of 1892 patients (treated 2006-2017), identified 92 (5%) who lived > 3 years following BM diagnosis, and performed per patient analyses. Results: Median age at diagnosis of BM was 57 years (range 19-77), 77% were women. The most common tumors were lung (50%), breast (26%), thyroid (7%) and skin (5%). 42% had tumors with drug-targetable oncoproteins (e.g. EGFR mutant) and 15% expressed hormonal receptors. ECOG was <2 in 70%. 47% had stage IV disease at diagnosis (75% with brain as the first site). 55% had controlled extracranial disease at the time of BM diagnosis. Median BM diameter was 1.5 cm (range 0.2-7) and 62% had a single lesion. Treatment was with surgery, radiosurgery, whole brain radiation (WBRT), or systemic therapy alone in 38%, 62%, 52%, and 4%, respectively. 53% received targeted- or immuno-therapy. Median follow up was 63 months (range 36-113). 61% failed intracranially at a median 24 months (range 1-99). 5 and 10- year survival (from BM diagnosis) was 82%, and 34%, respectively. Neither upfront WBRT nor other variables tested correlated with improved survival. In patients who died, an MRI was available within 3 months from death in 57%; of those 55% had no active intracranial disease, suggesting that the majority of deaths were non-neurologic. Conclusion: In general, LTS of BM had a limited number of BM, inactive extracranial disease, and drug targetable mutations.
Rubella virus infection typically presents as a mild illness in children; however, infection during pregnancy may cause the birth of an infant with congenital rubella syndrome (CRS). As of February 2017, India began introducing rubella-containing vaccine (RCV) into the public-sector childhood vaccination programme. Low-level RCV coverage among children over several years can result in an increase in CRS incidence by increasing the average age of infection without sufficiently reducing rubella incidence. We evaluated the impact of RCV introduction on CRS incidence across India's heterogeneous demographic and epidemiological contexts. We used a deterministic age-structured model that reflects Indian states’ rural and urban area-specific demography and vaccination coverage levels to simulate rubella dynamics and estimate CRS incidence with and without RCV introduction to the public sector. Our analysis suggests that current low-level private-sector vaccination has already slightly increased the burden of CRS in India. We additionally found that the effect of public-sector RCV introduction depends on the basic reproductive number, R0, of rubella. If R0 is five, a value empirically estimated from an array of settings, CRS incidence post-RCV introduction will likely decrease. However, if R0 is seven or nine, some states may experience short-term or annual increases in CRS, even if a long-term total reduction in cases (30 years) is expected. Investment in population-based serological surveys and India's fever/rash surveillance system will be key to monitoring the success of the vaccination programme.
We investigate the excitation and radiation of near-inertial internal gravity waves continuously excited by a latitudinally confined temporally fluctuating wind in a numerical model of a stratified ocean on a
-plane at mid-latitude. The surface wind forcing contains both high- and low-frequency components which excite propagating waves and a baroclinically unstable zonal jet respectively. Wentzel–Kramers–Brillouin (WKB) ray theory implies that near-inertial waves propagate strictly towards the equator. We seek to refine this view here by (i) adding the non-traditional Coriolis force (accounting for the horizontal component of the Earth’s rotation) into the equations of motion, in order to allow poleward sub-inertial propagation to occur, and (ii) relaxing the conceptual constraint of no zonal variability, to allow the zonal jet to undergo instability, to meander and to sustain an active field of mesoscale eddies, potentially impacting the excitation of near-inertial waves. The key results are that, while (i) permits weakly stratified waveguides with sub-inertial poleward wave propagation to develop in accord with theory, the sub-inertial energy flux observed is very small compared with the equatorward flux. Thus, in terms of energy radiated from the storm track, non-traditional effects are small for wind-driven near-inertial waves. The consequences of (ii) are much more pronounced. Refinement (ii) produces a radiating wave field that is bidirectional, i.e. with both poleward and equatorward components. We show that the presence of regions of significant background vorticity with horizontal scales significantly smaller than the width of the storm track provides the scale selection mechanism to excite waves with sufficiently super-inertial frequencies to propagate poleward distances of the order of 1000 km.
For forty eventful years, ending with the outbreak of the First World War, the Young Czech Party waged an unremitting struggle on behalf of Czech national interests within the limited constitutional framework of the Hapsburg Monarchy. Political activity for such a span of time would be enough to insure the party a niche in history, but in addition it dominated Czech politics for sixteen of those years and enlisted politicians of the caliber of Kaizl, Kramář, Rašín, and briefly Masaryk under its banner in their quest for elective office. The intent of this article is to evaluate the party's contributions to the development of the modern Czech political system by outlining its history and general orientation and by comparing party platforms with achievements.
We investigate the dynamic stability of stratified flow configurations characteristic of hydraulically controlled downslope flow over topography. Extraction of the correct ‘base state’ for stability analysis from spatially and temporally evolving flows that exhibit instability is not easy since the observed flow in most cases has already been modified by nonlinear interactions between the instability modes and the mean flow. Analytical studies, however, can yield steady solutions under idealized conditions which can then be analysed for stability. Following the latter approach, we study flow profiles whose essential character is determined by recently obtained solutions of Winters & Armi (J. Fluid Mech., vol. 753, 2014, pp. 80–103) for topographically controlled stratified flows. Their condition of optimal control necessitates a streamline bifurcation which then naturally produces a stagnant isolating layer overlying an accelerating stratified jet in the lee of the topography. We show that the inclusion of the isolating layer is an essential component of the stability analysis and further clarify the nature and mechanism of the instability in light of the wave-interaction theory. The spatial stability problem is also briefly examined in order to estimate the downstream location where finite-amplitude features might be manifested in streamwise slowly varying flows over topography.