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Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project

  • G. Winterer (a1) (a2) (a3), G. Androsova (a4), O. Bender (a5), D. Boraschi (a6), F. Borchers (a2), T.B. Dschietzig (a7), I. Feinkohl (a8), P. Fletcher (a9), J. Gallinat (a10), D. Hadzidiakos (a2), J.D. Haynes (a11), F. Heppner (a12), S. Hetzer (a11), J. Hendrikse (a13), B. Ittermann (a14), I.M.J. Kant (a15), A. Kraft (a16), A. Krannich (a16), R. Krause (a4), S. Kühn (a3) (a9) (a17), G. Lachmann (a2), S.J.T. van Montfort (a15), A. Müller (a2), P. Nürnberg (a18) (a19), K. Ofosu (a2), M. Pietsch (a20), T. Pischon (a8), J. Preller (a21), E. Renzulli (a22), K. Scheurer (a1) (a2), R. Schneider (a4), A.J.C. Slooter (a15), C. Spies (a2), E. Stamatakis (a9), H.D. Volk (a23), S. Weber (a20), A. Wolf (a2), F. Yürek (a2), N. Zacharias (a1) (a2) (a3) and BioCog consortium...

Abstract

Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions – particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost–benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is funded by the European Union. It is the goal of this research and development (R&D) project, which involves academic and industry partners throughout Europe, to deliver a multivariate algorithm based on clinical assessments as well as molecular and neuroimaging biomarkers to overcome the currently unsatisfying situation.

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Copyright

Corresponding author

*Corresponding author. Experimental and Clinical Research Center (ECRC), Department of Anesthesiology & Intensive Care Medicine, Charité – Universitätsmedizin Berlin, Campus Buch, Lindenberger Weg 80, 13125 Berlin, Germany. Fax: +49 30 450 7540767. Georg.winterer@charite.de (G. Winterer).

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www.biocog.eu.

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References

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Keywords

Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project

  • G. Winterer (a1) (a2) (a3), G. Androsova (a4), O. Bender (a5), D. Boraschi (a6), F. Borchers (a2), T.B. Dschietzig (a7), I. Feinkohl (a8), P. Fletcher (a9), J. Gallinat (a10), D. Hadzidiakos (a2), J.D. Haynes (a11), F. Heppner (a12), S. Hetzer (a11), J. Hendrikse (a13), B. Ittermann (a14), I.M.J. Kant (a15), A. Kraft (a16), A. Krannich (a16), R. Krause (a4), S. Kühn (a3) (a9) (a17), G. Lachmann (a2), S.J.T. van Montfort (a15), A. Müller (a2), P. Nürnberg (a18) (a19), K. Ofosu (a2), M. Pietsch (a20), T. Pischon (a8), J. Preller (a21), E. Renzulli (a22), K. Scheurer (a1) (a2), R. Schneider (a4), A.J.C. Slooter (a15), C. Spies (a2), E. Stamatakis (a9), H.D. Volk (a23), S. Weber (a20), A. Wolf (a2), F. Yürek (a2), N. Zacharias (a1) (a2) (a3) and BioCog consortium...

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Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project

  • G. Winterer (a1) (a2) (a3), G. Androsova (a4), O. Bender (a5), D. Boraschi (a6), F. Borchers (a2), T.B. Dschietzig (a7), I. Feinkohl (a8), P. Fletcher (a9), J. Gallinat (a10), D. Hadzidiakos (a2), J.D. Haynes (a11), F. Heppner (a12), S. Hetzer (a11), J. Hendrikse (a13), B. Ittermann (a14), I.M.J. Kant (a15), A. Kraft (a16), A. Krannich (a16), R. Krause (a4), S. Kühn (a3) (a9) (a17), G. Lachmann (a2), S.J.T. van Montfort (a15), A. Müller (a2), P. Nürnberg (a18) (a19), K. Ofosu (a2), M. Pietsch (a20), T. Pischon (a8), J. Preller (a21), E. Renzulli (a22), K. Scheurer (a1) (a2), R. Schneider (a4), A.J.C. Slooter (a15), C. Spies (a2), E. Stamatakis (a9), H.D. Volk (a23), S. Weber (a20), A. Wolf (a2), F. Yürek (a2), N. Zacharias (a1) (a2) (a3) and BioCog consortium...
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