Hostname: page-component-7c8c6479df-p566r Total loading time: 0 Render date: 2024-03-28T08:02:07.330Z Has data issue: false hasContentIssue false

Neural correlates of cognitive behavioural therapy in patients with schizophrenia

Published online by Cambridge University Press:  16 April 2020

M. Cabanis
Affiliation:
Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany
A. Krug
Affiliation:
Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany
M. Pyka
Affiliation:
Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany
H. Walter
Affiliation:
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany
G. Winterer
Affiliation:
Department of Psychiatry and Psychotherapy, Heinrich Heine University, Rhineland State Clinics for Psychiatry, Düsseldorf, Germany
B. Müller
Affiliation:
Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, Rhineland State Clinics for Psychiatry, Essen, Germany
J. Herrlich
Affiliation:
Department of Psychiatry and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt/Main, Germany
G. Wiedemann
Affiliation:
Clinic of Psychiatry and Psychotherapy, Clinical Centre, Fulda, Germany
K. Vogeley
Affiliation:
Department of Psychiatry and Psychotherapy, University of Cologne, Köln, Germany
A. Rapp
Affiliation:
Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany
S. Klingberg
Affiliation:
Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany
T. Kircher
Affiliation:
Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

There is evidence that patients with persecutory delusions tend to attribute excessively hypothetical positive events to internal causes and hypothetical negative events to external causes, arrive at hasty conclusions and fail in gathering and assessing adequate feedback, particularly when emotionally salient material is involved. Research on the neural correlates of the corresponding neural correlates and even more so on the potential effects of cognitive behavioral therapy (CBT) on the associated cerebral networks is almost unavailable.

The first and preliminary results of a multicentre fMRI study will be presented.

In this study eighty schizophrenia patients from the POSITIVE clinical trial and eighty healthy subjects were recruited at six German university hospitals (Bonn, Duisburg-Essen, Düsseldorf, Frankfurt, Cologne, Tubingen). After nine months of therapy (either with CBT or Supportive Therapy) patients and controls were re-examined enabling the study correlates of cerebral reorganization processes.

We found reliable differences in brain activation relating to phenomena of decision making under uncertainty, and biased attribution (self- vs. external reference of emotional events).

The comparison of both groups revealed significant decreased activation in key areas for decision making, self-reflection, self-relevance and agency attribution of patients with schizophrenia.

The preliminary data analysis of the still blinded treatment arms shows significantly increased activations in these areas after nine months of CBT. This suggest neuroplasitic changes according to relearning strategies in psychotic patients with schizophrenia and will hopefully give rise to a more widespread application of CBT in treatment of schizophrenia.

Type
P02-320
Copyright
Copyright © European Psychiatric Association 2011
Submit a response

Comments

No Comments have been published for this article.