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Chapter 11 - Monitoring and Advanced Control of Crystallization Processes

Published online by Cambridge University Press:  14 June 2019

By
Zoltan K. Nagy ,
Mitsuko Fujiwara  and
Richard D. Braatz
Edited by
Allan S. Myerson ,
Deniz Erdemir  and
Alfred Y. Lee
Allan S. Myerson
Affiliation:
Massachusetts Institute of Technology
Deniz Erdemir
Affiliation:
Bristol-Myers Squibb, USA
Alfred Y. Lee
Affiliation:
Merck & Co., Inc
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Summary

Crystallization is one of the main separation and purification processes in the pharmaceutical, biotechnology, food, microelectronics, fine and bulk chemicals industries. The production of more than 70 percent of all solid products involves at least one crystallization as a key processing step, which can have a significant effect on the overall performance of the entire production process and the properties of the final product. The control of crystallization processes is challenging because of the highly nonlinear dynamics, large variations in length and time scales at which the various simultaneous mechanisms occur, variations in crystallization rates over time owing to variations in the impurity profiles of chemical feedstocks, unexpected polymorphic transformations, and nonideal mixing conditions.

Type
Chapter
Information
Handbook of Industrial Crystallization , pp. 313 - 345
Publisher: Cambridge University Press
Print publication year: 2019

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