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Neuropathic Pain
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  • Cited by 1
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    This book has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Raoof, Ramin Willemen, Hanneke L D M and Eijkelkamp, Niels 2018. Divergent roles of immune cells and their mediators in pain. Rheumatology, Vol. 57, Issue. 3, p. 429.

  • Edited by Cory Toth, Department of Neurology, University of Calgary , Dwight E. Moulin, Department of Clinical Neurological Sciences, University of Western Ontario
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    Neuropathic Pain
    • Online ISBN: 9781139152211
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Book description

Central or peripheral neuropathic pain can be caused by a wide range of injuries, infections and diseases such as: spinal cord injury, multiple sclerosis, stroke, herpes zoster, diabetes and cancer. Many of these pain syndromes are difficult to treat, representing a challenge for many neurologists not routinely trained in pain management. Written by an international team of experts in the field, Neuropathic Pain: Causes, Management and Understanding gives readers an in-depth understanding of the multitude of conditions causing neuropathic pain. Epidemiology, clinical diagnosis, pathophysiology, outcome measurement and the best evidence-based management of individual and general neuropathic pain conditions are also described in depth. A unique chapter, written from a patient's viewpoint, gives new insight into how chronic neuropathic pain affects the lives of those patients with the condition. This book is essential reading for all pain specialists, neurologists, psychiatrists and anesthesiologists who wish to better understand their patients' neuropathic pain.


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Page 1 of 2

  • Chapter 7 - Pathophysiology of neuropathic pain: inflammatory mediators
    pp 77-89
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    This chapter summarizes a standard approach to identifying neuropathic pain for the clinician. For neuropathic pain, and for the condition of complex regional pain syndrome (CRPS) especially, the six Ss should be queried when obtaining details regarding the affected region. A useful tool to rapidly and accurately localize sources of chronic pain and assist in the diagnosis of causes of neuropathic pain is a pain diagram. The examination of a chronic pain patient should start with an appropriate and directed general examination including a neurological examination. Quantitative sensory testing (QST) provides indirect information used to evaluate underlying sensory function abnormalities using only small, portable tools and with less time requirement than protocols developed by the German Neuropathic Research Network. In the future, bedside QST is expected to continue to play a role in determining potential pain mechanisms to help direct further evaluation and treatment.
  • Chapter 9 - Diabetic and other peripheral neuropathies
    pp 101-119
  • View abstract


    Diagnostic testing for determining the sources of neuropathic pain has evolved over time. Good clinical practice requires that the clinician takes a good history and performs an appropriate clinical examination to establish the diagnosis of neuropathic pain as possible or probable. Quantitative sensory testing (QST) is helpful in the early diagnosis and follow-up of peripheral neuropathy affecting small-fiber function. Peripheral nerve biopsy was performed in certain circumstances, such as when vasculitis, amyloid, or an unspecified inflammatory condition could be the etiology of peripheral neuropathy. Computerized tomography (CT) and magnetic resonance imaging (MRI) scans can facilitate diagnoses by identifying causes of central and peripheral nervous tissue ischemia, demyelination, compression, or infiltration. Functional MRI works on the principle that regional cerebral blood flow (rCBF) is related to regional cerebral activity. Autonomic function testing relies on indirectly accessing the function of unmyelinated postganglionic fibers, which cannot be tested directly by conventional neurophysiological techniques.
  • Chapter 10 - Post-herpetic neuralgia: the prevention of a scourge
    pp 120-129
  • View abstract


    Epidemiology has long been a neglected aspect of clinical research related to neuropathic pain and until recently there was no reliable information regarding the general epidemiology of this type of pain, most notably its prevalence and incidence. Two large population-based postal surveys have been carried out to estimate the overall prevalence of chronic pain with neuropathic characteristics (NC) in the general population. The large epidemiological survey of the burden of illness due to chronic neuropathic pain was undertaken in the French general population. Assessment of quality of life in patients with or without pain was based on the Medical Outcome Short Form 12 scale (MOS-SF-12). The surveys have shown that all domains of quality of life, sleep duration, and quality and symptoms of depression and anxiety are consistently more impaired in subjects reporting chronic pain with NC than in subjects reporting chronic pain without NC.
  • Chapter 11 - Painful conditions affecting the nerve roots and plexus
    pp 130-144
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    This chapter describes commonly used peripheral nerve injury models of neuropathic pain. It introduces the central, non-traumatic and orofacial models of neuropathic pain. Neuropathic pain of central origin is observed clinically after traumatic incidents, such as stroke or spinal cord injury (SCI). An important consideration is that the pain experience, in humans and animals, has both sensory and emotional dimensions. The focus on nociception in pain research has been associated with the clinical failure of several potential pain medicines. An understanding of both sensory and affective dimensions of pain may improve translational research. Further, interpretations made from animal nerve injury models should be considered in the context of gender, age, and species/strain studied. Finally, it appears that no animal nerve injury model is without limitations, therefore, behavioral, physiological, and biochemical studies can only speculate on the relevance of experimental findings to human neuropathic pain.
  • Chapter 13 - Central pain symptoms in multiple sclerosis
    pp 156-169
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    This chapter explores the cellular and genetic mechanisms important in the development of neuropathic pain and other forms of chronic pain related to the phenomenon of sensitization. Peripheral sensitization contributes to pain hypersensitivity found at the location of tissue damage and/or inflammation. The chapter reviews the events that underlie pain as well as the anatomical and pharmacological basis for nociceptive sensations and chronic pain. Nociceptor excitation via various transient receptor potential (TRP) channels can result from a number of contributing processes. Transduction of mechanical, thermal, and chemical stimuli begins with membrane depolarization, which, if sufficient, transforms into an action potential. There are three classes of cell surface proteins at the sensory neuron important for sensory transduction: ion channels, metabotropic G protein-coupled receptors (GPCRs), and receptors for neurotrophins or cytokines. An important concept in central modulation of pain is the central inhibitory pathways and networks.