An early form of eurypterids (Chelicerata), Archopterus anjiensis n. gen. n. sp., is described from the uppermost Ordovician Wenchang Formation of Anji County, Zhejiang Province, South China. It is the earliest record of eurypterids in China and likely the oldest representative of the Adelophthalmidae. The species, represented by a single specimen, is diagnosed by a ventrally preserved prosoma with a parabolic carapace, Hughmilleria-type prosomal appendages, a short vase-shaped metastoma, and a three-segmented type A (female) genital appendage. The specimen is preserved, together with diverse sponges, graptolites and occasional nautiloids, in a 10 m thick shale of marine deep-water setting. This finding extends the stratigraphic range of adelophthalmids from the previously recorded early Silurian into the Late Ordovician (some 10 million years older) and supports an earlier cryptic phase of eurypterid evolution in Gondwana.

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Abstract

Model order reduction (MOR) can provide low-dimensional numerical models for fast simulation. Unlike intrusive methods, nonintrusive methods are attractive because they can be applied even without access to full order models (FOMs). Since nonintrusive MOR methods strongly rely on snapshots of the FOMs, constructing good snapshot sets becomes crucial. In this work, we propose a novel active-learning-based approach for use in conjunction with nonintrusive MOR methods. It is based on two crucial novelties. First, our approach uses joint space sampling to prepare a data pool of the training data. The training data are selected from the data pool using a greedy strategy supported by an error estimator based on Gaussian process regression. Second, we introduce a case-independent validation strategy based on probably approximately correct learning. While the methods proposed here can be applied to different MOR methods, we test them here with artificial neural networks and operator inference.

Meat quality is not only influenced by breed but also rearing environment. The aim of this study was to evaluate the influence of different housing environments on growth performance, carcase traits, meat quality, physiological response pre-slaughter and fatty acid composition in two pig breeds. A total of 120 growing pigs at 60-70 days of age were arranged in a 2 × 2 factorial design with the breeds (Duroc × Landrace × Large White [D × L × LW] and Duroc × Landrace × Min pig [D × L × M]) and environmental enrichment (barren concrete floor or enriched with straw bedding) as factors. Each treatment was performed in triplicate with ten pigs per replicate. The pigs housed in the enriched environment exhibited a higher average daily gain, average daily feed intake, saturated fatty acid percentage and backfat depth than the pigs reared in the barren environment. Plasma cortisol levels were lower and growth hormone higher in enriched compared to barren pens. The D × L × M pigs showed lower cooking loss compared with the D × L × LW pigs. Moreover, the D × L × M pigs exhibited poor growth performance but had a better water-holding capacity. Only carcase traits and meat quality interaction effects were observed. We concluded that an enriched environment can reduce preslaughter stress and improve the growth performance of pigs and modulate the fatty acid composition of pork products.

Doyle’s (2013) theoretical survey of discount functions criticizes two parametric families abbreviated as CRDI and CADI families. We show that Doyle’s criticisms are based on a mathematical mistake and are incorrect.

We assessed susceptibility patterns to newer antimicrobial agents among clinical carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from patients in long-term acute-care hospitals (LTACHs) from 2014 to 2015. Meropenem-vaborbactam and imipenem-relebactam nonsusceptibility were observed among 9.9% and 9.1% of isolates, respectively. Nonsusceptibility to ceftazidime-avibactam (1.1%) and plazomicin (0.8%) were uncommon.

Background: While managing patients with high-grade gliomas (HGG), predicting recurrence, or differentiating between pseudoprogression (radiation necrosis) and true tumour progression would be invaluable in improving overall prognosis. Characterizing small RNA (sRNA) expression profiles from plasma-derived extracellular vesicles (EVs) over the course of a patient’s treatments, may allow for patient-specific treatment modifications and improve outcomes. Methods: EVs were isolated using Vn96 capture from plasma obtained longitudinally from HGG patients perioperatively and with routine, follow-up surveillance imaging. sRNA was enriched from the EVs, upon which sequencing and unsupervised hierarchal clustering of sRNA signatures were completed. Expression profiles were grouped longitudinally with the clinical status of patients. Results: Cluster analysis of sequences from nine HGG patients, has revealed a sRNA signature that is able to distinguish between tumours showing evidence of progression and those remaining stable over time. Those samples obtained from patients where a clinical diagnosis of tumour progression or pseudoprogression were uncertain, were found to cluster into progression vs. stable signatures. Clinical follow up of these patients will reveal the predictive value of these identified clusters. Conclusions: These preliminary findings demonstrate the potential utility of small RNA profiling of EVs obtained from patients with high-grade gliomas as non-invasive biomarkers for recurrent/progressive disease or stability/pseudoprogression.

Background: Despite efforts toward gender equality in clinical trial enrollment, females are frequently underrepresented and gender-specific data analysis is often unavailable. The purpose of this study was to determine if gender equality exists in the management of degenerative lumbar disease. Methods: Part 1: A systematic scoping review was conducted according to PRISMA guidelines, in order to synthesize the adult surgical literature regarding gender differences in pre- and post-operative clinical assessment scores for patients diagnosed with degenerative lumbar disease.

Part 2: An ambispective cohort analysis (multi-variate logistic regression) of the Canadian Spine Outcomes Research Network registry was performed to address knowledge gaps identified in “Part 1”. Results: Part 1: Thirty articles were identified, accounting for 32,951 patients. Female patients have worse absolute pre-operative pain, disability and health-related quality-of-life (HRQoL). Following surgery, females have worse absolute pain, disability, and HRQoL, but demonstrate an equal or greater interval change compared to males.

Part 2: Data was analyzed for 5,039 patients. Significant gender differences in pre-operative utilization of healthcare resources (medication use, diagnostic testing, medical and allied healthcare professional visits) were identified. Conclusions: Significant gender disparities in clinical assessment scores and the pre-operative utilization of healthcare resources were identified for patients undergoing surgery for degenerative lumbar disease.

The diversity of mid-Cretaceous tyrannosauroids is poorly understood. We describe a partial tyrannosauroid femur from the Albian–Cenomanian Wayan Formation of eastern Idaho that helps to fill in an important spatiotemporal gap in the North American record of tyrannosaurs. This specimen, consisting of the proximal half of the bone, is morphologically similar to the femur of Moros intrepidus, a small-bodied tyrannosauroid from the Cenomanian Mussentuchit Member of the Cedar Mountain Formation of Utah, but not referable to this taxon. The Wayan femur lacks an autapomorphy diagnostic for Moros intrepidus, indicating the presence of a previously unrecognized tyrannosauroid taxon in the early Late Cretaceous of Laramidia. Histological results indicate that, at the time of death, this individual was at least five years old, skeletally immature, and undergoing growth at a moderate rate. The addition of this tyrannosauroid to the Wayan-Vaughn Assemblage provides additional evidence for the widespread distribution of various tyrannosauroid taxa in Laramidia during the early Late Cretaceous.

Academics and practitioners have shown a growing interest in automobile reverse supply chain (RSC) management as a result of the rise of circular economy and the development of Industry 4.0. Accurate quantity prediction enhances the efficiency of all decision levels in automobile RSC, not only the recovery of end-of-life vehicles (ELVs). Therefore, a comprehensive state-of-the-art review, evaluating ELVs quantity forecasting methodologies and summarizing the main variables influencing forecasting outcomes, is conducted to throw shed light on future research directions.

We describe a large outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) involving an acute-care hospital emergency department during December 2020 and January 2021, in which 27 healthcare personnel worked while infectious, resulting in multiple opportunities for SARS-CoV-2 transmission to patients and other healthcare personnel. We provide recommendations for improving infection prevention and control.