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11 - Programmed cell death

Published online by Cambridge University Press:  22 August 2009

By
Rafael Linden  and
Benjamin E. Reese
Edited by
Evelyne Sernagor ,
Stephen Eglen ,
Bill Harris  and
Rachel Wong
Rafael Linden
Affiliation:
Instituto de BiofÍsica da UFRJ, CCS, bloco G, Cidade Universitaria, 21949-900, Rio de Janeiro, Brazil
Benjamin E. Reese
Affiliation:
Neuroscience Research Institute and Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA
Evelyne Sernagor
Affiliation:
University of Newcastle upon Tyne
Stephen Eglen
Affiliation:
University of Cambridge
Bill Harris
Affiliation:
University of Cambridge
Rachel Wong
Affiliation:
Washington University, St Louis
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Summary

Introduction

Interest in programmed cell death (PCD) emerged over a century ago (reviewed in Clarke and Clarke, 1996), and such naturally occurring cell death in the developing nervous system has been extensively documented (Oppenheim, 1991 for review). More recently, the concept of PCD has been the subject of some controversy mainly due to the overwhelming interest in one of its forms, apoptosis (Sloviter, 2002). For the purpose of this chapter, PCD is defined simply as a sequence of events based on cellular metabolism that leads to cell destruction (Lockshin and Zakeri, 2001; Guimarães and Linden, 2004), without commitment to particular morphological types.

Programmed cell death has been identified using a variety of techniques, though each of them is prone to errors when estimating the magnitude of cell loss. Estimating the size of the population based on counts of axons in developing nerves or tracts may be confounded by the simultaneous occurrence of both cell death and axonal ingrowth, and by the transient contaminating presence of other axonal populations. Estimates based on cell counts may be influenced by the continuous migration of differentiating cells into spatially delimited cell populations, as well as by the inclusion of other types of cells that are not so readily discriminable at earlier developmental stages. And while great progress has been made in understanding the molecular mechanisms of apoptosis in the last decade, multiple alternative pathways of PCD add a further degree of complexity in understanding developmental cell death and estimating its magnitude.

Type
Chapter
Information
Retinal Development , pp. 208 - 241
Publisher: Cambridge University Press
Print publication year: 2006

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  • Programmed cell death
    • By Rafael Linden, Instituto de BiofÍsica da UFRJ, CCS, bloco G, Cidade Universitaria, 21949-900, Rio de Janeiro, Brazil, Benjamin E. Reese, Neuroscience Research Institute and Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA
  • Edited by Evelyne Sernagor, University of Newcastle upon Tyne, Stephen Eglen, University of Cambridge, Bill Harris, University of Cambridge, Rachel Wong, Washington University, St Louis
  • Book: Retinal Development
  • Online publication: 22 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541629.013
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  • Programmed cell death
    • By Rafael Linden, Instituto de BiofÍsica da UFRJ, CCS, bloco G, Cidade Universitaria, 21949-900, Rio de Janeiro, Brazil, Benjamin E. Reese, Neuroscience Research Institute and Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA
  • Edited by Evelyne Sernagor, University of Newcastle upon Tyne, Stephen Eglen, University of Cambridge, Bill Harris, University of Cambridge, Rachel Wong, Washington University, St Louis
  • Book: Retinal Development
  • Online publication: 22 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541629.013
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  • Programmed cell death
    • By Rafael Linden, Instituto de BiofÍsica da UFRJ, CCS, bloco G, Cidade Universitaria, 21949-900, Rio de Janeiro, Brazil, Benjamin E. Reese, Neuroscience Research Institute and Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA
  • Edited by Evelyne Sernagor, University of Newcastle upon Tyne, Stephen Eglen, University of Cambridge, Bill Harris, University of Cambridge, Rachel Wong, Washington University, St Louis
  • Book: Retinal Development
  • Online publication: 22 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541629.013
Available formats
×