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1 - Introduction – from eye field to eyesight

Published online by Cambridge University Press:  22 August 2009

Rachel O. L. Wong
Affiliation:
University of Washington, Seattle, USA
Evelyne Sernagor
Affiliation:
University of Newcastle upon Tyne
Stephen Eglen
Affiliation:
University of Cambridge
Bill Harris
Affiliation:
University of Cambridge
Rachel Wong
Affiliation:
Washington University, St Louis
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Summary

Vision begins at the retina, a light-sensitive tissue at the back of the eye that comprises highly organized, laminated networks of nerve cells. Investigating the mechanisms of retinal development is fundamentally important to gaining a basic knowledge of how vision is established. In this book, we present the sequence of developmental events and the mechanisms involved in shaping the structure and function of the vertebrate retina.

Formation of the eye

The eye is derived from three types of tissue during embryogenesis: the neural ectoderm gives rise to the retina and the retinal pigment epithelium (RPE), the mesoderm produces the cornea and sclera, and the lens originates from the surface ectoderm (epithelium). During embryogenesis (Figure 1.1), the eyes develop as a consequence of interactions between the surface ectoderm and the optic vesicles, evaginations of the diencephalon (forebrain). These optic vesicles are connected to the developing central nervous system by a stalk that later becomes the optic nerve. When the optic vesicles contact the ectoderm, inductive events take place to cause the epithelium to form a lens placode. The lens placode then invaginates, pinches off eventually and becomes the lens. During these events, the optic vesicle folds inwards and forms a bilayered cup, the optic cup. The outer layer of the optic cup differentiates into the RPE whereas the inner layer differentiates into the retina. The iris and ciliary body develop from the peripheral edges of the retina.

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Publisher: Cambridge University Press
Print publication year: 2006

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References

Cajal, S. R. (1972). The Structure of the Retina, ed. Thorpe, S. A. and Glickstein, M.. Springfield, Illinois: Charles ThomasGoogle Scholar
Mann, I. (1964). The Development of the Human Eye. New York: Grune and Stralton.Google Scholar
Morgan, J., Huckfeldt, R. and Wong, R. O. (2005). Imaging techniques in retinal research. Exp. Eye Res., 80, 297–306CrossRefGoogle ScholarPubMed
Wässle, H. (2004). Parallel processing in the mammalian retina. Nat. Rev. Neurosci., 5, 747–57CrossRefGoogle ScholarPubMed

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