To send content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about sending content to .
To send content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about sending to your Kindle.
Note you can select to send to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Recent acceleration and thinning of Thwaites Glacier, West Antarctica, motivates investigation of the controls upon, and stability of, its present ice-flow pattern. Its eastern shear margin separates Thwaites Glacier from slower-flowing ice and the southern tributaries of Pine Island Glacier. Troughs in Thwaites Glacier’s bed topography bound nearly all of its tributaries, except along this eastern shear margin, which has no clear relationship with regional bed topography along most of its length. Here we use airborne ice-penetrating radar data from the Airborne Geophysical Survey of the Amundsen Sea Embayment, Antarctica (AGASEA) to investigate the nature of the bed across this margin. Radar data reveal slightly higher and rougher bed topography on the slower-flowing side of the margin, along with lower bed reflectivity. However, the change in bed reflectivity across the margin is partially explained by a change in bed roughness. From these observations, we infer that the position of the eastern shear margin is not strongly controlled by local bed topography or other bed properties. Given the potential for future increases in ice flux farther downstream, the eastern shear margin may be vulnerable to migration. However, there is no evidence that this margin is migrating presently, despite ongoing changes farther downstream.
We present satellite-derived velocity patterns for the two contrasting melt seasons of 2009–10 across Russell Glacier catchment, a western, land-terminating sector of the Greenland ice sheet which encompasses the K(angerlussuaq)-transect. Results highlight great spatial heterogeneity in flow, indicating that structural controls such as bedrock geometry govern ice discharge into individual outlet troughs. Results also reveal strong seasonal flow variability extending 57 km up-glacier to 1200 m elevation, with the largest acceleration (100% over 11 days) occurring within 10 km of the margin coincident with spring melt. By late July 2010, 2 weeks before peak melt and runoff, 48 % of the 2400 km2 catchment had slowed to less than the winter mean. This observation supports the hypothesis that the subglacial hydrological system evolves from an inefficient distributed to an efficient drainage system, regulating flow dynamics. Despite this, the cumulative surface flux over the record melt year of 2010 was still greater compared with the perturbation over the average melt year of 2009. This study supports the proposition that local surface meltwater runoff couples to basal hydrology driving ice-sheet dynamics, and although the effect is nonlinear, our observations indicate that greater meltwater runoff yields increased net flux over this sector of the ice sheet.
Relationships between stable isotopes (δD–δ18O), ice facies and glacier structures have hitherto gone untested in the mid-latitude maritime glaciers of the Southern Hemisphere. Here, we present δD–δ18O values as part of a broader study of the structural glaciology of Fox Glacier, New Zealand. We analyzed 94 samples of δD–δ18O from a range of ice facies to investigate whether isotopes have potential for structural glaciological studies of a rapidly deforming glacier. The δD–δ18O measurements were aided by structural mapping and imagery from terminus time-lapse cameras. The current retreat phase was preceded by an advance of 1 km between 1984 and 2009, with the isotopic sampling and analysis undertaken at the end of that advance (2010/11). Stable isotopes from debris-bearing shear planes near the terminus, interpreted as thrust faults, are isotopically enriched compared with the surrounding ice. When plotted on co-isotopic diagrams (δD–δ18O), ice sampled from the shear planes appears to show a subtle, but distinctive isotopic signal compared with the surrounding clean ice on the lower glacier. Hence, stable isotopes (δD–δ18O) have potential within the structural glaciology field, but larger sample numbers than reported here may be required to establish isotopic contrasts between a broad range of ice facies and glacier structures.
There is evidence for health benefits from ‘Palaeolithic’ diets; however, there are a few data on the acute effects of rationally designed Palaeolithic-type meals. In the present study, we used Palaeolithic diet principles to construct meals comprising readily available ingredients: fish and a variety of plants, selected to be rich in fibre and phyto-nutrients. We investigated the acute effects of two Palaeolithic-type meals (PAL 1 and PAL 2) and a reference meal based on WHO guidelines (REF), on blood glucose control, gut hormone responses and appetite regulation. Using a randomised cross-over trial design, healthy subjects were given three meals on separate occasions. PAL2 and REF were matched for energy, protein, fat and carbohydrates; PAL1 contained more protein and energy. Plasma glucose, insulin, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and peptide YY (PYY) concentrations were measured over a period of 180 min. Satiation was assessed using electronic visual analogue scale (EVAS) scores. GLP-1 and PYY concentrations were significantly increased across 180 min for both PAL1 (P= 0·001 and P< 0·001) and PAL2 (P= 0·011 and P= 0·003) compared with the REF. Concomitant EVAS scores showed increased satiety. By contrast, GIP concentration was significantly suppressed. Positive incremental AUC over 120 min for glucose and insulin did not differ between the meals. Consumption of meals based on Palaeolithic diet principles resulted in significant increases in incretin and anorectic gut hormones and increased perceived satiety. Surprisingly, this was independent of the energy or protein content of the meal and therefore suggests potential benefits for reduced risk of obesity.
The effects of dietary carbohydrate and fat on feline health are not well understood. The effects of feeding diets moderately high in fat (HF; n 10; 30 % fat, 26 % carbohydrate as fed) or carbohydrate (HC; n 10; 11 % fat, 47 % carbohydrate), for 84 d, were investigated in healthy, adult cats (3·5 (sd 0·5) years). Data on indirect calorimetry, blood biomarkers, activity, play and cognition were collected at baseline, and at intervals throughout the study. Body composition was measured by dual-energy X-ray absorptiometry at baseline and on day 85. There were no significant main effects of diet on body weight and composition. When data were analysed over study day within diet, cats fed HF diets experienced a significant increase in body fat (P = 0·001) and body weight (P = 0·043) in contrast to cats consuming the HC diet that experienced no change in body fat or body weight (P = 0·762) throughout the study. Overall, energy expenditure was similar between diets (P = 0·356 (fasted), P = 0·086 (postprandial)) and respiratory quotient declined with exposure to the HF diet and increased with exposure to the HC diet (P < 0·001; fasted and postprandial). There was no difference in insulin sensitivity as an overall effect of diet (P = 0·266). Activity declined from baseline with exposure to both diets (HC: P = 0·002; HF: P = 0·01) but was not different between diets (P = 0·247). There was no effect of diet on play (P = 0·387) and cats consuming either the HF or HC diet did not successfully learn the cognitive test. Overall, cats adapt to dietary macronutrient content, and the implications of feeding HC and HF diets on risk for adiposity as driven by metabolic and behavioural mechanisms are discussed.
Walter Scott was the major novelist of the nineteenth century. ‘During the Romantic period, the “Author of Waverley” sold more novels than all the other novelists of the time put together’; a generation later he was still, ‘by several orders of magnitude, the author whose works had sold the largest number of copies in the English-speaking world.’ This popularity was accompanied by a commensurate critical prestige. The Victorians revered Scott as at once the last of the classics and the first of the moderns – the wizard who reanimated the ancient genres of ballad, epic and romance for an industrial-age reading public. His reputation stood if anything still higher outside Britain: from Russia to Italy, Ontario to Bengal, the historical novel exemplified the modernising national literary form of the novel as such. Scott’s fiction supplied a template for the epic ambitions of the next great medium of nation-making narrative, in the cinema of D. W. Griffith, and Waverley, Rob Roy, Ivanhoe and the rest continue to shape the fables of our postmodern global mass culture.
Scott’s achievement was comprehensively sidelined by the aesthetic revolutions of modernism, consolidated in Anglo-American criticism by works such as F. R. Leavis’s The Great Tradition (1948) and Ian Watt’s The Rise of the Novel (1957), which installed academic canons of moral and formal realism inhospitable to Scott’s practice. Twentieth-century taste made the Waverley Novels the literary equivalent of a Victorian municipal monument – dilapidated, unsightly, impeding the flow of traffic. The lip-service paid to Scott’s stature in the global history of the novel gave his reputation a lopsided cast: the once universally influential Great Unread, a tail without the comet. Recent decades have seen a refurbishing of that reputation, if so far confined to the academy, sustained by the new Edinburgh Edition of the Waverley Novels, a general reorientation of critical inquiry towards historicist approaches and (not least) a strong resurgence of the historical novel itself across the reading publics and credential-granting institutions of world literature.
The ambition to write an historical novel framed the early stages of Dickens's literary career. In May 1836 he signed a contract with John Macrone for a novel called ‘Gabriel Vardon, The Locksmith of London’, which he may have contemplated as early as 1833. ‘Gabriel Vardon’ was to be published in three volumes, a standard format established by the novels of Walter Scott, and would culminate in a treatment of the 1780 Gordon Riots, modelled on the scenes of urban insurrection in Scott's The Heart of Mid-Lothian (1818). The second number of Pickwick Papers had just appeared; its huge popularity still before it, Pickwick was classed as a series of comic sketches, ‘a periodical with only one article’, rather than a novel. Although ‘Gabriel Vardon’ would not be published until 1841, in weekly instalments and under the title Barnaby Rudge: A Tale of the Riots of 'Eighty, it has a claim to be regarded as Dickens's first venture in the novel as the genre was understood in the second quarter of the nineteenth century.
Dickens aimed at the prestige as well as the immense profits won by Walter Scott's Waverley novels (so called after the first in the series, Waverley, 1814). In his lifetime Scott ‘sold more novels than all the other novelists of the time put together’; by the late 1860s he was still, ‘by several orders of magnitude, the author whose works had sold the largest number of copies in the English-speaking world’.
In a fatal hour Robert Wringhim, the protagonist of James Hogg's novel The Private Memoirs and Confessions of a Justified Sinner (1824), meets a stranger who bears an uncanny physical resemblance to himself. Not only to himself: ‘I observed several times, when we were speaking of certain divines and their tenets, that his face assumed something of the appearance of theirs; and it struck me, that by setting his features into the mould of other people's, he entered at once into their conceptions and feelings’. The stranger, who calls himself Gil-Martin, explains the ‘cameleon art […] of changing [his] appearance’:
‘My countenance changes with my studies and sensations,’ said he. ‘It is a natural peculiarity in me, over which I have not full control. If I contemplate a man's features seriously, mine own gradually assume the very same appearance and character. And what is more, by contemplating a face minutely, I not only attain the same likeness, but, with the likeness, I attain the very same ideas as well as the same mode of arranging them, so that, you see, by looking at a person attentively, I by degrees assume his likeness, and by assuming his likeness I attain to the possession of his most secret thoughts.’
Such a virtuoso pitch of observation assumes ‘likeness’ in order to empty it: draining the other person's interiority, rendering him as a set of surface effects, erasing his integrity and uniqueness.
In the century between David Hume's A Treatise of Human Nature and Thomas Carlyle's The French Revolution Lowland Scotland became one of the advanced centres of European and North Atlantic literary culture. Scotland's entry into modernity followed its dissolution into 'North Britain' at the 1707 Union of Parliaments. The French Revolution marked a turning point in Scotland as in England, although with different dynamics. Scotland's literary eminence declined sharply after the 1830s, despite an influential spate of liberal and radical periodicals encouraged by Reform. The accumulation of urban wealth through colonial trade, agricultural improvement and early industrialization financed the institutions that comprised the republic of letters of the Lowland Scottish Enlightenment. Hugh Blair buttressed his defence of the antiquity of Fingal with the appeal to conjectural history, in an argument that exposed its circular, fictive logic. The most drastic unwriting of Scottish Romanticism occurred, however, in a sequence of works that terminated the post-Enlightenment era of national literature in Edinburgh.
Scottish fiction, meaning at once fiction produced in Scotland and fiction that made Scotland its topic, became one of the leading genres of European Romanticism in the decade after Waterloo. Its distinctive forms, the three-volume historical novel, magazine tale and fictitious regional memoir, were the product and fuel of a spectacular Edinburgh publishing boom in the first quarter of the nineteenth century, which was also characterized by innovations in the periodical genres of quarterly review and monthly magazine. The proportion of British fiction titles produced in Scotland rose steeply from a mere 0.5 percent in the first decade of the century to 4.4 percent in the 1810s and then to 12 percent in the 1820s, reaching 15 percent, or 54 out of 359 titles, in the peak years of 1822-5. Following a nationwide financial crash in 1826, booksellers cut back the production of new novels, especially in Scotland, and invested instead in miscellanies, serials, reprints, and the genres of “useful knowledge.” “Our publishers of the proud northern metropolis seem to have lost all pluck since the lamented death of their great father, Mr Constable,” remarked Fraser's Magazine in 1830: “the vaunted Modern Athens is fast dwindling away into a mere spelling-book and primer manufactory.”
The meteoric career of Scottish fiction, as everyone at the time acknowledged, traced the career of an individual author, Walter Scott. The publication of Waverley in the summer of 1814 accelerated a modest rate of growth into a regional bonanza.
Minocycline, a tetracycline derivative with pleiotropic biological effects, exhibits anti-inflammatory properties in several models of CNS disease. In addition to reducing production of inflammatory mediators, it has been postulated that minocycline might also be directly neuroprotective under these circumstances. Therefore, we investigated the effect of minocycline on primary cortical neuronal cultures exposed to a nitric oxide (NO)-donor. Cultures were assessed for neuronal survival, axon survival and markers of intracellular signaling pathways. The NO donor significantly increased neuronal death and minocycline was protective under these conditions. Furthermore NO-induced reductions in axonal length were significantly attenuated by minocycline. Improvements in axonal length were dependent on mitogen-activated protein kinase (MAP kinase)/extracellular signal-related kinase (Erk) signaling, whereas phosphatidylinositol 3-kinase (PI 3-kinase)/Akt signaling was important in neuronal survival. Further investigation into MAP kinase signaling pathways revealed inhibition of p38 MAP kinase and c-jun N-terminal kinase (JNK) signaling by minocycline. JNK pathways were activated by trophic factor-withdrawal and minocycline attenuated neuronal death induced by trophic withdrawal. These results indicate that, in addition to anti-inflammatory properties, minocycline has direct protective effects on neurons and provides further evidence for its use in disorders of the CNS.