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Chapter 15 - The Aging Kidney and End-stage Renal Disease

Published online by Cambridge University Press:  01 March 2017

Xin Jin (Joseph) Zhou
Affiliation:
Baylor University Medical Center, Dallas
Zoltan G. Laszik
Affiliation:
University of California, San Francisco
Tibor Nadasdy
Affiliation:
Ohio State University
Vivette D. D'Agati
Affiliation:
Columbia University, New York
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Publisher: Cambridge University Press
Print publication year: 2017

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References

CDC. The State of aging and health in America 2013. Report. Available from: www.cdc.gov/aging.Google Scholar
United Nations, Department of Economic and Social Affairs, Population Division (2013). World Population Ageing 2013. ST/ESA/SER.A/348.Google Scholar
United States Renal Data System. 2015 Annual Data Report: An overview of the epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2015 (www.usrds.org).Google Scholar
Kooman, JP, Broers, NJ, Usvyat, L, et al. Out of control: accelerated aging in uremia. Nephrol Dial Transplant 2013; 28:4854.Google Scholar
Stenvinkel, P, Larsson, TE. Chronic kidney disease: a clinical model of premature aging. Am J Kidney Dis 2013; 62:339351.Google Scholar
Levey, AS, Eckardt, KU, Tsukamoto, Y, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2005; 67:2089–100.Google Scholar
Coresh, J, Astor, BC, Greene, T, Eknoyan, G, Levey, AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:112.Google Scholar
Kidney Disease Outcome Quality Initiative (K/DOQI). Part 4. Definition and classification of stages of chronic kidney disease. Am J Kidney Dis 2002; 39(suppl):S4675.CrossRefGoogle Scholar
Zhou, XJ, Rakheja, D, Yu, XQ, et al. The aging kidney. Kidney Int 2008; 74:710720.CrossRefGoogle ScholarPubMed
Morrissey, PE, Yango, AF. Renal transplantation: older recipients and donors. Clin Geriatr Med 2006; 22:687707.Google Scholar
Lindeman, RD, Tobin, J, Shock, NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 1985; 33(4):278285.Google Scholar
Kimmel, PL, Lew, SQ, Bosch, JP. Nutrition, ageing and GFR: is age-associated decline inevitable? Nephrol Dial Transplant 1996; 11(Suppl 9):8588.Google Scholar
Musch, W, Verfaillie, L, Decaux, G. Age-related increase in plasma urea level and decrease in fractional urea excretion: clinical application in the syndrome of inappropriate secretion of antidiuretic hormone. Clin J Am Soc Nephrol 2006; 1(5):909–14.Google Scholar
Levey, AS, Coresh, J, Balk, E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 2003; 139:137147.Google Scholar
Cockcroft, DW, Gault, MH. Prediction of creatinine clearance from serum-creatinine. Nephron Exp Nephrol 1976; 16: 3141.Google Scholar
Levey, AS, Stevens, LA, Schmid, CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150:604612.Google Scholar
Garasto, S, Fusco, S, Corica, F, et al. Estimating glomerular filtration rate in older people. Biomed Res Int 2014; 2014:916542.CrossRefGoogle ScholarPubMed
Silva, FG. The aging kidney: a review – part I. Int Urol Nephrol 2005; 37:185205.CrossRefGoogle Scholar
Silva, FG. The aging kidney: a review – part II. Int Urol Nephrol 2005; 37:419–32.Google Scholar
Zhou, XJ, Saxena, R, Liu, ZH, Vaziri, ND, Silva, FG. Renal senescence in 2008: progress and challenges. Int Urol Nephrol 2008; 40:823839.CrossRefGoogle ScholarPubMed
Musso, CG, Oreopoulos, DG. Aging and physiological changes of the kidneys including changes in glomerular filtration rate. Nephron Physiol 2011; 119(Suppl 1):15.Google Scholar
Perazella, MA, Mahnensmith, RL. Hyperkalemia in the elderly: drugs exacerbate impaired potassium homeostasis. J Gen Intern Med 1997; 12:646656.CrossRefGoogle ScholarPubMed
Sands, JM. Urine concentrating and diluting ability during aging. J Gerontol A Biol Sci Med Sci 2012; 67:13521357.Google Scholar
Kirkland, JL, Lye, M, Levy, DW, Banerjee, AK. Patterns of urine flow and electrolyte excretion in healthy elderly people. Br Med J (Clin Res Ed) 1983; 287:16651667.CrossRefGoogle ScholarPubMed
Faull, CM, Holmes, C, Baylis, PH. Water balance in elderly people: is there a deficiency of vasopressin? Age Ageing 1993; 22:114120.Google Scholar
Eisenstaedt, R, Penninx, BW, Woodman, RC. Anemia in the elderly: current understanding and emerging concepts. Blood Rev 2006; 20:213226.Google Scholar
Ble, A, Fink, JC, Woodman, RC, et al. Renal function, erythropoietin, and anemia of older persons: the InCHIANTI study. Arch Intern Med 2005; 165:22222227.CrossRefGoogle ScholarPubMed
Ershler, WB, Sheng, S, McKelvey, J, et al. Serum erythropoietin and aging: a longitudinal analysis. J Am Geriatr Soc 2005; 53:13601365.Google Scholar
Ferrucci, L, Guralnik, JM, Bandinelli, S, et al. Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of proinflammatory markers. Br J Haematol 2007; 136:849855.Google Scholar
Zhang, Y, Kong, J, Deb, DK, Chang, A, Li, YC. Vitamin D receptor attenuates renal fibrosis by suppressing the renin–angiotensin system. J Am Soc Nephrol 2010; 21:966973.Google Scholar
Mensenkamp, AR, Hoenderop, JG, Bindels, RJ. Recent advances in renal tubular calcium reabsorption. Curr Opin Nephrol Hypertens 2006; 15:524529.Google Scholar
Chang, Q, Hoefs, S, van der Kemp, AW, et al. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 2005; 310:490493.CrossRefGoogle ScholarPubMed
Kuro-o, M, Matsumura, Y, Aizawa, H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390:4551.CrossRefGoogle ScholarPubMed
Briese, S, Wiesner, S, Will, JC, et al. Arterial and cardiac disease in young adults with childhood-onset end-stage renal disease – impact of calcium and vitamin D therapy. Nephrol Dial Transplant 2006; 21:19061914.CrossRefGoogle ScholarPubMed
Gutierrez, OM, Januzzi, JL, Isakova, T, et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation 2009; 119:25452552.Google Scholar
Foley, RN, Parfrey, PS, Hartnett, JD, et al. Clinical and echocardiographic disease in patients starting end-stage renal disease therapy. Kidney Int 1995; 47:186192.Google Scholar
Wang, S, Qin, L, Wu, T, et al. Elevated cardiac markers in chronic kidney disease as a consequence of hyperphosphatemia-induced cardiac myocyte injury. Med Sci Monit 2014; 20:20432053.Google ScholarPubMed
Hu, MC, Kuro-o, M, Moe, OW. αKlotho and vascular calcification: an evolving paradigm. Curr Opin Nephrol Hypertens 2014; 23(4):331339.Google Scholar
Brandenburg, VM, Cozzolino, M, Mazzaferro, S. Calcific uremic arteriopathy: a call for action. Semin Nephrol 2014; 34:641647.Google Scholar
Rutsky, EA, Rostand, SG. Pericarditis in end-stage renal disease: clinical characteristics and management. Semin Dialysis 1989; 2:25.Google Scholar
Rostand, SG, Rutsky, EA. Pericarditis in end-stage renal disease. Cardiol Clin 1990; 8:701.Google Scholar
Weiss, SW, Taw, RL, Hutchins, GM. Constrictive uremic pericarditis following hemodialysis for acute renal failure. Johns Hopkins Med J 1973; 132:301.Google Scholar
Mafra, D, Lobo, JC, Barros, AF, et al. Role of altered intestinal microbiota in systemic inflammation and cardiovascular disease chronic kidney disease. Future Microbiol 2014; 9:399410.Google Scholar
Vaziri, ND, Yuan, J, Rahimi, A, et al. Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation. Nephrol Dial Transplant 2012; 27:26862693.Google Scholar
Vaziri, ND, Yuan, J, Norris, K. Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in CKD. Am J Nephrol 2012; 37:16.Google Scholar
Vaziri, ND, Wong, J, Pahl, MV, et al. Chronic kidney disease alters the composition of intestinal microbial flora. Kidney Int 2013; 83:308315.Google Scholar
Aronov, PA, Luo, FJ, Plummer, NS, et al. Colonic contribution to uremic solutes. J Am Soc Nephrol 2011; 22:17691776.Google Scholar
Silver, J, Naveh-Many, T. FGF23 and secondary hyperparathyroidism in chronic kidney disease. Nat Rev Nephrol 2013; 9:641649.Google Scholar
Moe, S, Drueke, T, Cunningham, J, et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69:19451953.Google Scholar
Chauhan, V, Kelepouris, E, Chauhan, N, Vaid, M. Current concepts and management strategies in chronic kidney disease – mineral and bone disorder. South Med J 2012; 105:470485.Google Scholar
Bover, J, Ureña, P, Brandenburg, V, et al. Adynamic bone disease: from bone to vessels in chronic kidney. Semin Nephrol 2014; 34:626640.Google Scholar
Van Buren, P, Velez, R, Vaziri, ND, Zhou, XJ. Iron overdose: a contributor to adverse outcomes in randomizes trials of anemia correction in CKD. Int Urol Nephrol 2012; 44:499507.Google Scholar
Drueke, TB, Massy, ZA. Beta-2-microglobulin. Semin Dial 2009; 22:378380.Google Scholar
Yamamoto, S, Kazama, JJ, Narita, I, Naiki, H, Gejyo, F. Recent progress in understanding dialysis-related amyloidosis. Bone 2009; 45(Suppl 1):s3942.Google Scholar
Takayama, F, Miyazaki, S, Morita, T, Hirasawa, Y, Jiwa, T. Dialysis related amyloidosis of the heart in long-term dialysis patients. Kidney Int 2001; 78:81728176.Google Scholar
Susantitaphong, P, Dember, LM, Jaber, BL. Dialysis-associated amyloidosis. In Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations (Picken, MM, Dogan, A, Herrera, GA, Eds). Current Clinical Pathology series. Humana Press, Springer, Switzerland, 2015, pp. 8194.Google Scholar
Centers for Disease Control and Prevention (CDC). Prevalence of chronic kidney disease and associated risk factors – United States, 1999–2004. MMWR Morb Mortal Wkly Rep 2007; 56(8):161165.Google Scholar
Tuttle, KR, Bakris, GL, Bilous, RW, et al. Diabetic kidney disease: a report from an ADA Consensus Conference. Am J Kidney Dis 2014; 64:510533.Google Scholar
Frassinetti, FP, Ellis, PA, Roderick, PJ, et al. Causes of end-stage renal failure in black patients starting renal replacement therapy. Am J Kidney Dis 2000; 36:301309.Google Scholar
Meyrier, A. Nephrosclerosis: update on a centenarian. Nephrol Dial Transplant 2015; 30:1833–41.Google Scholar
Parsa, A, Kao, WH, Xie, D, et al. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med 2013; 369:21832196.Google Scholar
Hill, GS. Hypertensive nephrosclerosis. Curr Opin Nephrol Hypertens 2008; 17:266270.Google Scholar
Kopp, JB. Rethinking hypertensive kidney disease: arterionephrosclerosis as a genetic, metabolic, and inflammatory disorder. Curr Opin Nephrol Hypertens 2013; 22:266272.Google Scholar
Kincaid-Smith, P. Hypothesis: obesity and the insulin resistance syndrome play a major role in end-stage renal failure attributed to hypertension and labeled ‘hypertensive nephro-sclerosis’. J Hypertens 2004; 22:10511055.Google Scholar
Hill, GS, Heudes, D, Jacquot, C, Gauthier, E, Bariety, J. Morpho-metric evidence for impairment of real autoregulation in advanced essential hypertension. Kidney Int 2006; 69:823831.Google Scholar
Ayodele, OE, Alebiosu, CO. Burden of chronic kidney disease: an international perspective. Adv Chronic Kidney Dis 2010; 17:215224.Google Scholar
Barsoum, RS. Chronic kidney disease in the developing world. New Engl J Med 2006; 354:997999.Google Scholar
Harambat, J, van Stralen, KJ, Kim, JJ, Tizard, EJ. Epidemiology of chronic kidney disease in children. Pediatr Nephrol 2012; 27:363373.Google Scholar
Groothoff, JW. Long-term outcomes of children with end-stage renal disease. Pediatr Nephrol 2005; 20:849853.Google Scholar
Warady, BA, Chadha, V. chronic kidney disease in children: the global perspective. Pediatr Nephrol 2007; 22:19992009.Google Scholar
Tada, S, Yamagishi, J, Kobayashi, H, Hata, Y, Kobari, T. The incidence of simple renal cyst by computed tomography. Clin Radiol 1983; 34(4):437439.Google Scholar
Zhou, XJ, Laszik, ZG, Silva, FG. Anatomical changes in the aging kidney. In The Aging Kidney in Health and Disease (Macias-Nunez, JF, Cameron, JS, Oreopoulos, DG, Eds.). Springer; 2007, pp. 3954.Google Scholar
Nyengaard, JR, Bendtsen, TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 1992; 232:194201.CrossRefGoogle ScholarPubMed
Bertram, JF, Douglas-Denton, RN, Diouf, B, Hughson, MD, Hoy, WE. Human nephron number: implications for health and disease. Pediatr Nephrol 2011 26:15291533.Google Scholar
Hughson, MD, Douglas-Denton, R, Bertram, JF, Hoy, WE. Hypertension, glomerular number, and birth weight in African-Americans and white subjects in the southeastern United States. Kidney Int 2006; 69:671678.CrossRefGoogle ScholarPubMed
Keller, G, Zimmer, G, Mall, G, Ritz, E, Amann, K. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348:101108.Google Scholar
Hughson, MD, Puelles, VG, Hoy, WE, et al. Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. Nephrol Dial Transplant 2014; 29:13991409.Google Scholar
Chevalier, RL, Forbes, MS. Generation and evolution of atubular glomeruli in the progression of renal disorders. J Am Soc Nephrol 2008; 19:197206.Google Scholar
White, KE, Marshall, SM, Bilous, RW. Prevalence of atubular glomeruli in type 2 diabetic patients with nephropathy. Nephrol Dial Transplant 2008;23:35393545.Google Scholar
Najafian, B, Crosson, JT, Kim, Y, Mauer, M. Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes. J Am Soc Nephrol 2006; 17(4 Suppl 2):S5360.Google Scholar
Gibson, IW, Downie, TT, More, IA, Lindop, GB. Atubular glomeruli and glomerular cysts – a possible pathway for nephron loss in the human kidney? J Pathol 1996; 179:421426.Google Scholar
Kasiske, BL. Relationship between vascular disease and age-associated changes in the human kidney. Kidney Int 1987; 31:11531159.Google Scholar
Kaplan, C, Pasternack, B, Shah, H, Gallo, G. Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 1975; 80:227234.Google Scholar
Smith, SM, Hoy, WE, Cobb, L. Low incidence of glomerulosclerosis in normal kidneys. Arch Pathol Lab Med 1989; 113:12531255.Google Scholar
Hill, GS, Heudes, D, Bariety, J. Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. Kidney Int 2003; 63(3):10271036.Google Scholar
Hodgin, JB, Bitzer, M, Wickman, L, et al. Glomerular aging and focal global glomerulosclerosis: a podometric perspective. J Am Soc Nephrol 2015; 26: 3162–78.Google Scholar
Wanner, N, Hartleben, B, Herbach, N, et al. Unraveling the role of podocyte turnover in glomerular aging and injury. J Am Soc Nephrol 2014; 25:707716.Google Scholar
Nath, KA. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 1992; 20:117.Google Scholar
Eknoyan, G, McDonald, MA, Appel, D, Truong, LD. Chronic tubulo-interstitial nephritis: correlation between structural and functional findings. Kidney Int 1990; 38:736743.Google Scholar
Nadasdy, T, Laszik, Z, Blick, KE, Johnson, DL, Silva, FG. Tubular atrophy in the end-stage kidney: a lectin and immunohistochemical study. Hum Pathol 1994; 25:2228.Google Scholar
Larsen, CP, Beggs, ML, Saeed, M, et al. Histopathologic findings associated with APOL1 risk variants in chronic kidney disease. Mod Pathol 2015; 28:95102.Google Scholar
Tracy, RE, Ishii, T. What is ‘nephrosclerosis’? Lessons from the US, Japan, and Mexico. Nephrol Dial Transplant 2000; 15:13571366.Google Scholar
Tracy, RE, Malcom, GT, Oalmann, MC, et al. Renal microvascular features of hypertension in Japan, Guatemala, and the United States. Arch Pathol Lab Med 1992; 116:5055.Google Scholar
Tracy, RE, Newman, WP 3rd, Wattigney, WA, et al. Histologic features of atherosclerosis and hypertension from autopsies of young individuals in a defined geographic population: the Bogalusa Heart Study. Atherosclerosis 1995; 116:163179.Google Scholar
Tracy, RE, Parra, D, Eisaguirre, W, Torres Balanza, RA. Influence of arteriolar hyalinization on arterial intimal fibroplasia in the renal cortex of subjects in the United States, Peru, and Bolivia, applicable also to other populations. Am J Hypertens 2002; 15:10641073.Google Scholar
Tracy, RE. Age trends of renal arteriolar hyalinization explored with the aid of serial sections. Nephron Clin Pract 2007; 105(4):c171177.Google Scholar
Zhou, XJ, Fenves, A, Vaziri, ND, Saxena, R. Renal changes with aging and end-stage renal disease. In Heptinstall’sPathology of the Kidney, 7th Ed (Jennette, JC, et al., Eds.). Wolters Gluwer, Philadalphia, PA, 2015.Google Scholar
Hughson, MD, Johnson, K, Young, RJ, Hoy, WE, Bertram, JF. Glomerular size and glomerular sclerosis: relationship to disease categories, glomerular solidification, and ischemic obsolescence. Am J Kidney Dis 2002; 39:679688.Google Scholar
Hughson, MD, Fox, M, Garvin, AJ. Pathology of the end-stage kidney after dialysis. Progress Reprod Urinary Tract Pathol 1990; 2:157.Google Scholar
Raju, DL, Cantarovich, M, Brisson, ML, Tchervenkov, J, Lipman, ML. Primary hyperoxaluria: clinical course, diagnosis, and treatment after kidney failure. Am J Kidney Dis 2008; 51:e1e5.CrossRefGoogle ScholarPubMed
Hughson, MD, McManus, JFA, Hennigar, GR. Studies on end-stage kidneys. II. Embryonal hyperplasia of Bowman’s capsular epithelium. Am J Pathol 1978; 91:7184.Google ScholarPubMed
Tracy, RE. Blood pressure related separately to parenchymal fibrosis and vasculopathy of the kidney. Am J Kidney Dis 1992; 20:124131.Google Scholar
Cendron, M. Reflux nephropathy. J Pediatr Urol 2008; 4:414–21. (Erratum in: J Pediatr Urol 2009; 5:75.)Google Scholar
Cotran, RS. Glomerulosclerosis in reflux nephropathy. Kidney Int 1982; 21:528.Google Scholar
Buckalew, VM Jr., Shey, HM. Renal disease from habitual antipyretic analgesic consumption: an assessment of the epidemiological evidence. Medicine 1986; 11:291.Google Scholar
Dunnill, MS, Millard, PR, Oliver, D. Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis. J Clin Pathol 1977; 30:868.Google Scholar
Feiner, HD, Katz, LA, Gallo, GR. Acquired cystic disease of the kidney in chronic dialysis patients. Urology 1981; 17:260264.Google Scholar
Choyke, PL. Acquired cystic kidney disease. Eur Radiol 2000; 10:17161721.Google Scholar
Ishikawa, I, Saito, Y, Asaka, M, et al. Twenty-year follow-up of acquired renal cystic disease. Clin Nephrol 2003; 59:153159.Google Scholar
Ishikawa, I, Yuri, T, Kitada, H, Shinoda, A. Regression of acquired cystic disease of the kidney after successful renal transplantation. Am J Nephrol 1983; 3:310314.Google Scholar
Ishikawa, I, Saito, A, Chikazawa, Y, et al. Cystic renal cell carcinoma, suspected because of lack of regression of renal cysts after renal transplantation in a dialysis patient with acquired renal cystic disease. Clin Exp Nephrol 2003; 7:8184.Google Scholar
Jenkins, DA, Temple, RM, Winney, RJ, et al. Effect of treatment mode on the natural history of acquired cystic renal disease of the kidney in patients on renal replacement therapy. Nephrol Dial Transplant 1992; 7:613617.Google Scholar
Denton, MD, Magee, CC, Ovuworie, C, et al. Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis. Kidney Int 2002; 61:22012209.Google Scholar
Petrolla, AA, MacLennan, GT. Renal cell carcinoma associated with end stage renal disease. J Urol 2006; 176:345.Google Scholar
Kojima, Y, Takahara, S, Miyake, O, et al. Renal cell carcinoma in dialysis patients: a single center experience. Int J Urol 2006; 13:10451048.CrossRefGoogle ScholarPubMed
Hughson, MD, Buchwald, D, Fox, M. Renal neoplasia and acquired cystic disease in patients receiving long-term dialysis. Arch Pathol Lab Med 1986; 110:592601.Google Scholar
Heinz-Peer, G, Schoder, M, Rand, T, Mayer, G, Mostbeck, GH. Prevalence of acquired cystic kidney disease and tumors in native kidneys of renal transplant recipients: a prospective US study. Radiology 1995; 195:667671.Google Scholar
Moudouni, SM, Lakmichi, A, Tligui, M, et al. Renal cell carcinoma of native kidney in renal transplant recipients. BJU Int 2006; 98:298302.Google Scholar
Neuzillet, Y, Lay, F, Luccioni, A, et al. De novo renal cell carcinoma of native kidney in renal transplant recipients. Cancer 2005; 103:251257.Google Scholar
Tickoo, SK, deParalta-Venturina, MN, Harik, LR, et al. Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. Am J Surg Pathol 2006; 30:141153.Google Scholar
Flamming, S. Renal cell carcinoma in acquired cystic kidney disease. Histopathology 2010; 56:395400Google Scholar
Yoshida, M, Yao, M, Ishikawa, I, et al. Somatic von HippelLindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney. Genes Chromosomes Cancer 2002; 35:359364.Google Scholar
Hughson, MD, Bigler, S, Dickman, K, Kovacs, G. Renal cell carcinoma of end-stage renal disease: an analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification. Mod Pathol 1999; 12:301309.Google Scholar
Lubensky, IA, Schmidt, L, Zhuang, Z, et al. Hereditary, and sporadic papillary renal cell carcinomas with c-met mutations share a distinct morphologic phenotype. Am J Pathol 1999; 155:517526.Google Scholar
Farivar-Mohseni, H, Perlmutter, AE, Wilson, S, et al. Renal cell carcinoma and end stage renal disease. J Urol 2006; 175:20182020.Google Scholar
Peces, R, Martínez-Ara, J, Miguel, JL, et al. Renal cell carcinoma coexistent with other renal disease: clinico-pathological features in re-dialysis patients and those receiving dialysis or renal transplantation. Nephrol Dial Transplant 2004; 19:27892796.CrossRefGoogle ScholarPubMed
Lopez-Otin, C, Blasco, MA, Patridge, L, Serrano, M, Kroemer, G. The hallmarks of aging. Cell 2013; 153:11941217.Google Scholar
Jiang, H, Ju, Z, Rudolph, KL. Telomere shortening and ageing. Z Gerontol Geriatr 2007; 40(5):314324.Google Scholar
Melk, A, Ramassar, V, Helms, LM, et al. Telomere shortening in kidneys with age. J Am Soc Nephrol 2000; 11(3):444453.Google Scholar
Ramirez, R. Carracedo, J, Soriano, S, et al. Stress-induced premature senescence in mononuclear cells from patients on long-term hemodialysis. Am J Kidney Dis 2005; 45:353359.Google Scholar
Carrero, JJ Stenvinkel, P, Fellström, B, et al. Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent hemodialysis patients. J Intern Med 2008; 263:302312.Google Scholar
Hybertson Gao, B, Bose, SK, McCord, JM. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med 2011; 32:234246.Google Scholar
Houben, JM, Moonen, HJ, van Schooten, FJ, Hageman, GJ. Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med 2008; 44:235246.Google Scholar
Kooman, JP, Kotanko, P, Schols, AM, Shiels, PG, Stenvinkel, P. Chronic kidney disease and premature ageing. Nat Rev Nephrol 2014; 10:732742.Google Scholar
Baylis, C. Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system. Exp Gerontol 2005; 40:271278.Google Scholar
Baylis, C. Nitric oxide synthase derangements and hypertension in kidney disease. Curr Opin Nephrol Hypertens 2012; 21:16.Google Scholar
Vaziri, ND, Ni, Z, Wang, XQ, Oveisi, F, Zhou, XJ. Downregulation of nitric oxide synthase in chronic renal insufficiency: role of excess PTH. Am J Physiol 1998; 274:F642649.Google Scholar
Vermeij, WP, Hoeijmakers, JH, Pothof, J. Aging: not all DNA damage is equal. Curr Opin Genet Dev 2014; 26:124130.Google Scholar
Corredor, Z, Stoyanova, E, Rodríguez-Ribera, L, et al. Genomic damage as a biomarker of chronic kidney disease status. Environ Mol Mutagen 2015; 56:301312.Google Scholar
Basso, N, Paglia, N, Stella, I, et al. Protective effect of the inhibition of the renin–angiotensin system on aging. Regul Pept 2005; 128:247252.Google Scholar
de Cavanagh, EM, Piotrkowski, B, Basso, N, et al. Enalapril and losartan attenuate mitochondrial dysfunction in aged rats. FASEB J 2003; 17:10961098.Google Scholar
Gentile, G, Remuzzi, G, Ruggenenti, P. Dual renin–angiotensin system blockade for nephroprotection: still under scrutiny. Nephron. 2015; 129:3941.Google Scholar
Kurosu, H, Yamamoto, M, Clark, JD, et al. Suppression of aging in mice by the hormone Klotho. Science 2005; 309:18291833.Google Scholar
Urakawa, I, Yamazaki, Y, Shimada, T, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006; 444:770774.Google Scholar
Hu, MC, Shiizaki, K, Kuro-o, M, Moe, OW. Fibroblast growth factor 23 and klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol 2013; 75:503533.Google Scholar
Ohnishi, M, Nakatani, T, Lanske, B, Razzaque, MS. In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels. Circ Cardiovasc Genet 2009; 2(6):583590.Google Scholar
Ohnishi, M, Razzaque, MS. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 2010; 24:35623571.Google Scholar
Torres, PU, Prie, D, Molina-Bletry, V, Beck, L, et al. Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 2007; 71:730737.Google Scholar
Yamada, Y, Ando, F, Niino, N, Shimokata, H. Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med 2005; 83:5057.Google Scholar
Arking, DE, Krebsova, A, Macek, M, Sr, et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A 2002; 99(2):856861.Google Scholar
Ichikawa, S, Imel, EA, Kreiter, ML, et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest 2007; 117(9):26842691.Google Scholar
Barker, SL, Pastor, J, Carranza, D, et al. The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody. Nephrol Dial Transplant 2015; 30:223233.Google Scholar
Meyra, JA, Hu, MC. αklotho and chronic kidney disease. Vitam Horm 2016; 101:257310.Google Scholar
Licastro, F, Candore, G, Lio, D, et al. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2005; 2:821.Google Scholar
Carrero, JJ, Stenvinkel, P. Inflammation in end-stage renal disease – what have we learned in 10 years? Semin Dial 2010; 23:498509.Google Scholar
Lovisa, S, Zeisberg, M, Kalluri, R. Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis. Trends Endocrinol Metab 2016; 27:681–95.Google Scholar
Farris, AB, Colvin, RB. Renal interstitial fibrosis: mechanisms and evaluation. Curr Opin Nephrol Hypertens 2012; 21:289300.Google Scholar
Zeiberg, M, Neilson, EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 2010; 21:18191834.Google Scholar
Remuzzi, G, Benigni, A, Remuzzi, A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest 2006; 116:288296.Google Scholar
Eddy, AA. Overview of the cellular and molecular basis of kidney fibrosis. Kidney Int Suppl 2014; 4:28.Google Scholar
Aldigier, JC, Kanjanbuch, T, Ma, LJ, Brown, NJ, Fogo, AB. Regression of existing glomerulosclerosis by inhibition of aldosterone. J Am Soc Nephrol 2005; 16:33063314.Google Scholar
Schena, FP, Strippoli, GFM, Wankelmuth, P. Renal growth factors: past present and future. Am J Nephrol 1999; 19:308312.Google Scholar
Fogo, AB. Mechanisms in nephrosclerosis and hypertension-beyond hemodynamics. J Nephrol Suppl 2001; 14:S63S69.Google Scholar
Epstein, M. Aldosterone and the hypertensive kidney: its emerging role as a mediator of progressive renal dysfunction: a paradigm shift. J Hypertens 2001; 19:829842.Google Scholar
Yu, F, Wu, LH, Tan, Y, et al. Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 international society of nephrology and renal pathology society system. Kidney Int 2010; 77:820829.Google Scholar
Eddy, AA. The origin of scar-forming kidney myofibroblasts. Nat Med 2013; 19:964966.Google Scholar
Yang, J, Liu, Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001; 159:14651475.Google Scholar
Copeland, JW, Beaumont, BW, Merrilees, MJ, Pilmore, HL. Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells; effects of rapamycin, mycophenolate, cyclosporine, azathioprine, and methylprednisolone. Transplantation 2007; 83:809814.Google Scholar
Zeisberg, M, Strutz, F, Müller, GA. Renal fibrosis: an update. Curr Opin Nephrol Hypertens 2001;10:315320.Google Scholar
Zoja, C, Abbate, M, Remuzzi, G. Progression of chronic kidney disease: insights from animal models. Curr Opin Nephrol Hypertens 2006; 15:250257.Google Scholar
Fogo, AB. Renal fibrosis: not just PAI-1 in the sky. J Clin Invest 2003; 112:326328.Google Scholar
Saxena, R, Yu, X, Giraldo, M, et al. Renal transplantation in the elderly. Int Urol Nephrol 2009; 41:195210.Google Scholar
Coresh, J. CKD prognosis: beyond the traditional outcomes. Am J Kidney Dis 2009; 54:13.Google Scholar
Carson, RC, Juszczak, M, Davenport, A, Burns, A. Is maximum conservative management an equivalent treatment option to dialysis for elderly patients with significant comorbid disease? Clin J Am Soc Nephrol 2009; 4:16111619.Google Scholar
Chandna, SM, Silva-Gane, MD, Marshall, C, et al. Survival of elderly patients with stage 5 CKD: comparison of conservative management and renal replacement therapy. Nephrol Dial Transplant 2011; 26:16081614.Google Scholar

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