The sustainability of rigid packaging can be increased by using biocomposites in packaging. Existing frameworks have some limitations such as are made to assess a few aspects, conventional packaging parameters are considered, etc. Biocomposite has a slightly different scenario at various life cycle stages, like the end-of-life cycle process. To assess the sustainability of biocomposite rigid packaging, we must consider parameters related to the biocomposite-based rigid packaging materials life cycle. These are categorised into different aspects of sustainability and life cycle phases.

We study the kinematics, dynamics and flow fields generated by an oscillating, compliant membrane hydrofoil extracting energy from a uniform water stream at a chord-based Reynolds number $Re \approx 3 \times 10^4$. Hydrodynamic forces during the foil's motion cause the membrane to dynamically morph its shape, effectively increasing the camber during the oscillation cycle. The membrane's deflection is modelled using the Young–Laplace equation, with pressure term approximated from thin-airfoil theory. Simultaneous tracking of the membrane deformation and the surrounding flow field using laser profiling and particle image velocimetry, respectively, reveals the role of dynamic cambering in stabilizing the leading-edge vortices on the membrane. In this regime of operation, we obtain up to 160 % higher power extraction when compared to a rigid, symmetric hydrofoil. The present work provides a demonstration of how passive compliance of soft materials interacting with fluids may be exploited in tidal and fluvial energy extraction.

Understanding how and why exotic species use their habitats is crucial for defining effective conservation strategies. We aimed to investigate habitat use by an exotic population of squirrel monkeys living in an Atlantic Forest fragment and identify factors associated with their habitat preferences. Over 6 months of scan sampling observations, we collected data on native and exotic plants consumed by the squirrel monkeys, food availability, and interactions between the squirrel monkeys and the native common marmosets. We also georeferenced the estimated centroid point of the study group during each scan. Squirrel monkeys used Secondary Old Forest habitats more often than the other habitats available. The consumption of native and exotic plants and the association with common marmoset appear to have influenced the habitat use of the exotic squirrel monkeys; however, the choice habitat did not demonstrate to be associated with food availability. The exotic squirrel monkeys preferred to use less disturbed habitats to consume a high amount of food (often associated with the common marmoset), potentially optimizing their food intake. Our findings demonstrated the adaptive success of an exotic primate in its non-natural habitat and the key role of the plant community in maintaining this population.

The subtle but crucial effects of large-scale forcing on the small-scale velocity-gradient (VG) dynamics is examined using direct numerical simulation (DNS) data of incompressible turbulence. The interplay among large-scale forcing, inertia, pressure and viscous effects is characterised as a function of local streamline geometry and VG magnitude (Frobenius norm). When conditioned on local topology, forcing: (i) counteracts inertial and viscous action in the strain-dominated nodal topologies; and (ii) balances pressure action in the rotation-dominated unstable focal topologies. Unexpectedly, forcing acts to reduce VG magnitudes in regions of strong dissipation. In these regions, forcing balances the non-local pressure effects whereas viscous action offsets the nonlinear inertial effects. In regions of very low dissipation, forcing combines with inertia and pressure effects to offset viscous action. With regard to the probability distribution of the normalised VG invariants, the primary role of forcing is to nullify certain features (dilatational probability currents) of inertia, pressure and viscous action. This results in the emergence of universal statistical features (solenoidal probability currents) that are determined largely by inertia–pressure–viscous interactions. These findings serve to enhance our understanding of small-scale processes in turbulence and guide VG model development.

Protected areas have numerous roles (such as biodiversity preservation, the development of scientific research and the sustainable use of natural resources), but they are under threat from political and economic forces. The 837 000-ha Serra do Divisor National Park (SDNP) in the south-western Brazilian Amazon combines the conservation of natural resources and the maintenance of the productive activities of c. 400 resident families. The Brazilian and Peruvian governments have proposed a road linking Acre (Brazil) to Ucayali (Peru) that would bisect the SDNP. Another threat to the SDNP is a bill proposing its downgrading to an ‘environmental protection area’. This study aims to map the land cover of the SDNP and its surroundings from 1988 to 2018 and to analyse the dynamics of land-use change. Analysis of Landsat satellite images with supervised classification using the MaxVer algorithm show that, during the 30-year period, pasture showed the highest absolute land-cover gain, with 1986 ha in the interior and 7661 ha along the periphery of the SDNP. Only 1% of the park’s primary forest was lost by 2018, but the proposed road and potential downgrading may result in accelerated deforestation and forest degradation in the near future.

At times funerary practices do not end with the deposition of the corpses in their final resting place, because occasionally these supposedly definitive burials are disturbed later. When we can confirm that people were mainly responsible for these disturbances, even when other natural taphonomic factors are present, then we have a situation of anthropic postfunerary manipulation of bodies and graves. Some precontact sites in northeastern Brazil have mortuary contexts with “anomalies” in the deposition of bodies into their graves. Applying a taphonomy-based approach, we analyze these cases and compare them to other burials with similar characteristics from central-eastern Brazil in our discussion of the “alternative” phenomenon of postburial manipulation. The evidence suggests that the anthropic disturbance of older burials and corpses should be understood not as a random event, but as an integral and meaningful part of the mortuary practices of ancient inhabitants from across different regions of Brazil throughout the Holocene. With this work we highlight not only unusual mortuary patterns of precontact human groups in Brazil and South America but also the importance of a taphonomic approach to understanding the complexity and variability of funerary and postfunerary actions.

This study describes a new species of Hypotrachyna subgenus Parmelinopsis from the south-eastern Cerrado (Brazilian savannah), a biodiversity hotspot. The species is especially common in open vegetation, including urban environments. Hypotrachyna neohorrescens sp. nov. is morphologically and chemically similar to H. horrescens. Nevertheless, phylogenetic analyses of the nuITS and mtSSU regions revealed that H. neohorrescens is a distinct species and closely related to the North American H. mcmulliniana, differing by the size of the laciniae and ascospores.

In this paper we apply Conley index theory in a covering space of an invariant set S, possibly not isolated, in order to describe the dynamics in S. More specifically, we consider the action of the covering translation group in order to define a topological separation of S which distinguishes the connections between the Morse sets within a Morse decomposition of S. The theory developed herein generalizes the classical connection matrix theory, since one obtains enriched information on the connection maps for non-isolated invariant sets, as well as for isolated invariant sets. Moreover, in the case of an infinite cyclic covering induced by a circle-valued Morse function, one proves that the Novikov differential of f is a particular case of the p-connection matrix defined herein.

From a systematic review framework, we assessed the preclinical evidence on the effectiveness of drug combinations for visceral leishmaniasis (VL) treatment. Research protocol was based on the PRISMA guideline. Research records were identified from Medline, Scopus and Web of Science. Animal models, infection and treatment protocols, parasitological and immunological outcomes were analysed. The SYRCLE's (SYstematic Review Center for Laboratory Animal Experimentation) toll was used to evaluate the risk of bias in all studies reviewed. Fourteen papers using mice, hamster and dogs were identified. Leishmania donovani was frequently used to induce VL, which was treated with 23 drugs in 40 different combinations. Most combinations allowed to reduce the effective dose, cost and time of treatment, in addition to improving the parasitological control of Leishmania spp. The benefits achieved from drug combinations were associated with an increased drug's half-life, direct parasitic toxicity and improved immune defences in infected hosts. Selection, performance and detection bias were the main limitations identified. Current evidence indicates that combination chemotherapy, especially those based on classical drugs (miltefosine, amphotericin B antimony-based compounds) and new drugs (CAL-101, PAM3Cys, tufisin and DB766), develops additive or synergistic interactions, which trigger trypanocidal and immunomodulatory effects associated with reduced parasite load, organ damage and better cure rates in VL.

A fully developed approach flow is necessary in open channel studies to maintain commonality among datasets obtained from different facilities. Two-component planar particle image velocimetry is used to study the characteristics of fully developed smooth open channel flow at a constant Reynolds number of 3.9 × 104 based on the maximum velocity and flow depth. The near-bed boundary layer is tripped to achieve a fully developed state and compared with the under- and over-tripped cases. The Reynolds stresses and higher-order moments are used as indicators to establish the fully developed state. Flow properties are explored by identifying uniform momentum zones (UMZs) using the probability density function of streamwise velocities. The instances are grouped based on the number of UMZs (NUMZ) and conditional averaging of flow variables of each group is used to evaluate the difference in flow properties between the developed and the developing flow. Large-scale ejections are found in the logarithmic layer when NUMZ is higher, whereas a lower number indicates the existence of large-scale sweeping motions. The distribution of the conditionally averaged ratio of the shear contribution from ejections and sweeps and velocity deficits shows a vertical variability in the fully developed state. The large-scale and pointwise quadrant events are used simultaneously to depict variability in inner flow properties between developing and fully developed flow which cannot be recognized in the mean flow characteristics. The sweep events have much higher shear generation in the outer flow in the fully developed state whereas the shear stress contribution from ejection is lower than that in developing flow.

Kelvin–Helmholtz (KH) instability plays a significant role in transport and mixing in various media such as hydrodynamic fluids, plasmas, geophysical flows and astrophysical situations. In this paper, we numerically explore this instability for a two-dimensional strongly coupled dusty plasma medium with rotational shear flows. We study this medium using a generalized hydrodynamic fluid model which treats it as a viscoelastic fluid. We consider the specific cases of rotating vorticity with abrupt radial profiles of rotation. In particular, single-circulation and multi-circulation vorticity shell profiles have been chosen. We observe the KH vortices at each circular interface between two relative rotating flows along with a pair of ingoing and outgoing wavefronts of transverse shear waves. Our studies show that due to the interplay between KH vortices and shear waves in the strongly coupled medium, the mixing and transport behaviour are much better than those of standard inviscid hydrodynamic fluids. In the interest of substantiating the mixing and transport behaviour, the generalized hydrodynamic fluid model is extended to include Lagrangian tracer particles. The numerical dispersion of these tracer particles in a flow provides an estimate of the diffusion in such a medium. We present the preliminary observations of tracer distribution (cluster formation) and diffusion (mean square displacement) across the medium.

Background: Ischemic stroke occurs following trauma-related blunt cerebrovascular injury (BCVI) in up to 20% of cases. Preventative treatment includes antiplatelets, anticoagulants, and/or endovascular treatment (ET), but the optimal choice remains unclear. The objective of this study was to compare the ischemic stroke rate between these three treatments. Methods: Following PRISMA guidelines, we queried the OVID Medline, Embase, Web of Science, and Cochrane Library databases from September 2019 to inception to identify studies reporting treatment-stratified outcomes in BCVI patients. Meta-analysis was performed to compare outcomes between the treatment groups, using odds ratios. Retrospective review of our institutional experience with BCVI outcomes was performed and added to the meta-analysis. Results: Analysis of seven comparative studies of antiplatelets (n=334) versus anticoagulation (n=325) found no significant difference in ischemic stroke rate (OR 1.27, 95%CI 0.40-3.99), but a decrease in hemorrhagic complications (OR 0.38, 95%CI 0.15-1.00). Analysis of seven comparative studies of antiplatelets/anticoagulants (n=805) versus ET (n=235) also found no significant difference in stroke rate (OR 0.71, 95%CI 0.35-1.42). Conclusions: Antiplatelets and anticoagulants were similarly effective in reducing ischemic stroke risk in BCVI, but antiplatelets were better tolerated in this trauma population. The addition of endovascular treatment did not further reduce stroke risk compared to antiplatelets or anticoagulants alone.

Background: Ancillary tests are indicated to diagnose death by neurological criteria whenever clinical neurological examination is unreliable, but their use is variable and subject to debate. Methods: Survey of Canadian intensivists providing care for potential organ donors. We included closed-ended questions and different clinical scenarios regarding the use of ancillary tests. Results: Among 550 identified intensivists, 249 completed the survey. Respondents indicated they would be comfortable diagnosing death based on neurological examination without ancillary tests in the following scenarios: movement in response to stimulation (48%), spontaneous peripheral movement (31%), inability to evaluate upper/lower extremity responses (34%) or both oculocephalic and oculo-caloric reflexes (17%), presence of high cervical spinal cord injury (16%) and within 24 hours of hypoxemic-ischemic brain injury (15%). Furthermore, 93% agreed that ancillary tests should always be conducted when a complete neurological examination is impossible, 89% if there remains possibility of residual sedative effect and 59% in suspected isolated brainstem death. Conclusions: Our findings suggest that Canadian intensivists have different perceptions on what constitutes a complete and reliable clinical neurological examination for determining death by neurologic criteria. Some self-reported practices also diverge from national recommendations. Further investigation and education are required to align and standardize medical practice across physicians and systems.

The COVID-19 pandemic has shone a spotlight on how health outcomes are unequally distributed among different population groups, with disadvantaged communities and individuals being disproportionality affected in terms of infection, morbidity and mortality, as well as vaccine access. Recently, there has been considerable debate about how social disadvantage and inequality intersect with developmental processes to result in a heightened susceptibility to environmental stressors, economic shocks and large-scale health emergencies. We argue that DOHaD Society members can make important contributions to addressing issues of inequality and improving community resilience in response to COVID-19. In order to do so, it is beneficial to engage with and adopt a social justice framework. We detail how DOHaD can align its research and policy recommendations with a social justice perspective to ensure that we contribute to improving the health of present and future generations in an equitable and socially just way.

Dietary supplements have been increasingly used by gym users and are often consumed without the guidance of a health professional. Moreover, the indiscriminate supplements use can have adverse health effects, such as changes in liver and kidney function. The aim of this study was to verify the association between dietary supplements intake with alterations in the liver and kidney function among gym users. A cross-sectional study was conducted with 594 gym users (mean age 37 (sd 14) years, 55·2 % women) from a city in southern Brazil. A questionnaire was used to evaluate the use of dietary supplements. The markers of the liver (alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase, γ-glutamyltransferase) and renal (creatinine and urea) function were also evaluated on a subsample of the study population. Data were analysed by binary logistic regression, adjusted for sex, age and education. The prevalence of dietary supplement intake was 36·0 %. Individuals who intake dietary supplements showed a higher prevalence to present slight alterations in the AST enzyme and in the urea after adjustments for potential confounders. In conclusion, the use of dietary supplement was associated with slight alterations in AST enzyme and in the urea among gym users. These findings show the importance of using supplements correctly, especially with guidance from professionals trained to avoid possible risks to health.