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Parenting practices and relationships with peers are crucial aspects of youth socialization. Although theoretically expected reciprocal associations between changes in maladaptive parenting and adolescent peer victimization exist, there is a lack of studies that examine this link and address the mediating mechanisms at the within-person level. This longitudinal study examined reciprocal relations between peer victimization and two types of maladaptive parenting including harsh punishment and psychological control, and the potential mediating roles of internalizing and externalizing problems within these relations, by disentangling between- and within-person effects. A total of 4,731 Chinese early adolescents (44.9% girls; Mage = 10.91 years, SD = 0.72) participated in a four-wave longitudinal study with 6-month intervals. The results of random intercept cross-lagged panel modeling showed: (a) harsh punishment did not directly predict peer victimization, and vice versa; (b) psychological control directly predicted peer victimization, and vice versa; (c) psychological control indirectly predicted peer victimization via internalizing problems, and peer victimization also indirectly predicted psychological control via internalizing problems. These findings provide evidence of a bidirectional spillover effect between psychological control and peer victimization at the within-person level, suggesting Chinese early adolescents may become caught in a vicious cycle directly or indirectly via their internalizing problems.
Neuronal intranuclear inclusion disease (NIID) is a rare slowly progressive neurodegenerative disorder that is characterized pathologically by the presence of eosinophilic intranuclear inclusions. NIID is a heterogeneous disease with diverse clinical manifestations, making diagnosis difficult. Here, we analyzed the clinical, pathological, and radiological features of Chinese NIID patients to improve our understanding of NIID.
Methods:
A total of 17 patients with sporadic NIID were recruited from the Ruijin Hospital Database between 2014 and 2021. Clinical patient information and brain MRI data were collected. All of the patients underwent standard skin biopsy procedures.
Results:
The average age of onset for symptoms was 60.18 years, and the average duration of illness was 4.06 years. All patients were diagnosed with NIID due to the presence of intranuclear inclusions confirmed by skin biopsy. Tremor was the most common initial symptom. The average ages at onset and at diagnosis were both lower in patients with tremor than in patients without tremor. NIID may be a systemic disease that affects multiple organs, for one patient had a history of chronic renal insufficiency for more than 10 years. In addition to high-intensity U-fibers signals on diffusion-weighted imaging, there were several other MRI findings, such as focal leukoencephalopathy and cortical swelling. Encephalitic episodes followed by reversible leukoencephalopathy was another important imaging feature of NIID.
Conclusion:
The clinical manifestations of NIID are highly variable. Tremor may be the most common initial symptom in certain cohorts. Encephalitic episodes followed by reversible asymmetric leukoencephalopathy may also indicate this disease.
The effects of early thiamine use on clinical outcomes in critically ill patients with acute kidney injury (AKI) are unclear. The purpose of this study was to investigate the associations between early thiamine administration and clinical outcomes in critically ill patients with AKI. The data of critically ill patients with AKI within 48 h after ICU admission were extracted from the Medical Information Mart for Intensive Care III (MIMIC III) database. PSM was used to match patients early receiving thiamine treatment to those not early receiving thiamine treatment. The association between early thiamine use and in-hospital mortality due to AKI was determined using a logistic regression model. A total of 15 066 AKI patients were eligible for study inclusion. After propensity score matching (PSM), 734 pairs of patients who did and did not receive thiamine treatment in the early stage were established. Early thiamine use was associated with lower in-hospital mortality (OR 0·65; 95 % CI 0·49, 0·87; P < 0·001) and 90-d mortality (OR 0·58; 95 % CI 0·45, 0·74; P < 0·001), and it was also associated with the recovery of renal function (OR 1·26; 95 % CI 1·17, 1·36; P < 0·001). In the subgroup analysis, early thiamine administration was associated with lower in-hospital mortality in patients with stages 1 to 2 AKI. Early thiamine use was associated with improved short-term survival in critically ill patients with AKI. It was possible beneficial role in patients with stages 1 to 2 AKI according to the Kidney Disease: Improving Global Outcomes criteria.
With the popularization of carbon and nitrogen stable-isotope analysis methods used on archaeological samples from Xinjiang, the ancient paleodiet there has been revealed. However, research about isotopic analysis combined with environmental factors is rare, especially in such a variable and complex climate as that of the Tianshan region. We systematically analyzed the δ13C and δ15N results from animals and humans for dietary reconstruction of nomadic pastoralists from the Tianshan region during 3900–1200 cal BP. The δ13C and δ15N values for animals (sheep/goat, horse and cattle; n = 57) have a wide range from –20.8‰ to –14.7‰ for δ13C (–19.2 ± 1.0‰) and 3.2‰ to 9.9‰ for δ15N (7.0 ± 1.2‰). The δ13C and δ15N values from humans range from –19.6 to –12.3‰ (–16.0 ± 1.5‰) and 7.1 to 16.7‰ (–13.6 ± 1.5‰), respectively. The animal δ15N results indicate that the dry environment in the Tianshan region may result in elevated δ15N values. Synthesizing animal and human isotope results suggests that the inhabitants engaged in mobile herding economies subsidized with crops and wild animal meat from the Tianshan Mountains. In conclusion, we found that the regional environment closely relates to crop types, and temporal climate change has an effect on human dietary structure. Therefore, climate condition cannot be ignored when studying human paleodiet.
Influenza is a major human respiratory pathogen. Due to the high levels of influenza-like illness (ILI) in Zhejiang, China, the control and prevention of influenza was challenging during the 2017–2018 season. To identify the clinical spectrum of illness related to influenza and characterise the circulating influenza virus strains during this period, the characteristics of ILI were studied. Viral sequencing and phylogenetic analyses were conducted to investigate the virus types, substitutions at the amino acid level and phylogenetic relationships between sequences. This study has shown that the 2017/18 influenza season was characterised by the co-circulation of influenza A (H1N1) pdm09, A (H3N2) and B viruses (both Yamagata and Victoria lineage). From week 36 of 2017 to week 12 of 2018, ILI cases accounted for 5.58% of the total number of outpatient and emergency patient visits at the surveillance sites. Several amino acid substitutions were detected. Vaccination mismatch may be a potential reason for the high percentage of ILI. Furthermore, it is likely that multiple viral introductions played a role in the endemic co-circulation of influenza in Zhejiang, China. More detailed information regarding the molecular epidemiology of influenza should be included in long-term influenza surveillance.
The twinning and slip modes of a rolled magnesium alloy sheet were investigated through quasi-in-situ tensile tests that were carried out along the rolling direction at room temperature with a constant strain rate. Scanning electron microscopy and electron backscattered diffraction observations were used to identify activated twinning and slip systems. Schmid factors were calculated to analyze different deformation modes. The analyses show that a small number of {10-12} tensile twins were present during deformation, and these twins resulted from the accommodation of compression along the tensile direction. Post-deformation examination revealed the dominance of prismatic <a> slip.
Site selection for Antarctic research stations is of great importance and is necessary to support Antarctic expeditions. Site selection is affected by both the scientific investigations planned and the expected life of stations following construction. In the site allocation process, an efficient spatial data management system is required to manage various criteria and a robust allocation method is important to handle decision uncertainties. The aim of this study was to build a criteria system and to conduct a site selection process with aid from geographical information systems (GIS) and the fuzzy analytical hierarchy process (FAHP). In considering the natural environment and building conditions, fifteen factors were used as multiple evaluation sub-criteria and grouped into four main criteria: scientific research, environment, logistical support and topography. Comparisons were made between potentially suitable areas and the locations of existing stations and camps to demonstrate fitness-for-use of the allocation results. Finally, the suitability map was applied to identify candidate sites for a new Chinese research station by considering the position of current stations and areas of scientific interest. This model offers a comprehensive methodology for decision-makers in the assessment of potential Antarctic research station sites.
The decomposition mechanism of block copolymer templates inside as-synthesized mesostructured solids has been systematically studied using solid-state 1H magic angle spinning nuclear magnetic resonance spectroscopy, thermogravimetric analysis, and high-vacuum Fourier transform infrared spectrometry. It is shown that there exists hydrogen-bonding interaction between silanols and block copolymers at the inorganic–organic interface in the self-assembled as-synthesized mesostructured solids, which plays an important role in protecting the surfactants against decomposition during the high-temperature hydrothermal treatment process. Increasing silanol concentration can enhance the hydrogen-bonding interaction and thus shows better “protection” effect. Moreover, the thermal decomposition of the block copolymer in as-synthesized mesostructured solids in air commences at higher temperatures compared with that in acidic solution or in air, providing further evidence in support of the silanol protection mechanism.
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