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Blazar OJ287 exhibits large thermal flares at least twice every 12 years. The times of these flares have been predicted successfully using the model of a quasi-Keplerian eccentric black hole binary where the secondary impacts the accretion disk of the primary, creating the thermal flares. New measurements of the historical light curve have been combined with the observations of the 2015 November/December flare to identify the impact record since year 1886, and to constrain the orbit of the binary. The orbital solution shows that the binary period, now 12.062 years, is decreasing at the rate of 36 days per century. This corresponds to an energy loss to gravitational waves that is 6.5 ± 4 % less than the rate predicted by the standard quadrupolar gravitational wave (GW) emission. We show that the difference is due to higher order gravitational radiation reaction terms that include the dominant order tail contributions.
Interpretation of ice-core records in terms of changes in atmospheric concentrations requires understanding of the various parameters within air–snow transfer functions. the dry-deposition velocity is one of these parameters, dependent on local meteorological conditions and thereby also affected by climate changes. We have determined aerosol dry-deposition velocities by measurements of aerosol particle-number concentration and the vertical wind component with an eddy-covariance system close to the Swedish and Finnish research stations Wasa and Aboa in Dronning Maud Land, Antarctica. Measurements were performed over a smooth, snow-covered area and over moderately rough, rocky ground during 4 and 19 days, respectively, in January 2000. the median dry-deposition velocity determined 5.25 mabove the surface was 0.33 and 0.80 cm s–1, respectively. the large difference between the two sites was mainly due to the stratification of the surface boundary layer, the surface albedo and the surface roughness height. the dry-deposition number fluxes were dominated by the particle-size modes defined as ultrafine and Aitken, withmean diameters around 14 and 42 nm, respectively. A larger dry-deposition velocity, owing to stronger Brownian diffusion, for the smaller ultrafine mode was verified by the measurements.
Obsessive–compulsive disorder (OCD) is a chronic psychiatric disorder leading to considerable distress and disability. Therapies are effective in a majority of paediatric patients, however, many only get partial response. It is therefore important to study the underlying pathophysiology of the disorder.
1H magnetic resonance spectroscopy (MRS) was used to study the concentration of brain metabolites in four different locations (cingulate gyrus and sulcus, occipital cortex, thalamus and right caudate nucleus). Treatment-naive children and adolescents with OCD (13 subjects) were compared with a group of healthy age- and gender-matched subjects (11 subjects). Multivariate analyses were performed on the concentration values.
No separation between controls and patients was found. However, a correlation between metabolite concentrations and symptom severity as measured with the Children’s Yale-Brown Obsessive–Compulsive Scale (CY-BOCS) was found. Strongest was the correlation with the CY-BOCS obsession subscore and aspartate and choline in the caudate nucleus (positively correlated with obsessions), lipids at 2 and 0.9 ppm in thalamus, and occipital glutamate+glutamine, N-acetylaspartate and myo-inosytol (negatively correlated with obsessions).
The observed correlations between 1H MRS and CY-BOCS in treatment-naive patients further supports an occipital involvement in OCD. The results are consistent with our previous study on adult OCD patients. The 1H MRS data were not supportive of a separation between the patient and control groups.
We present the most up-to-date and complete multi-wavelength correlation analysis on luminosity properties of TeV BL Lacs. Correlation function (power law or linear) parameters are calculated based on linear regression method. Using the lower energy luminosities of a sample of 182 non-TeV BL Lacs and the generated functions, minimum level of VHE gamma-ray emission was calculated for each non-TeV BL Lacs. This multi wavelength prediction method gives us a list of best candidates to be observed with current generation of Imaging Air Cherenkov Telescopes.
The blazar QSO B0218+357 is the first gravitationally lensed blazar detected in the very high energy (VHE, E > 100 GeV) gamma-ray spectral range (Ahnen et al. 2016). It is gravitationally lensed by the intervening galaxy B0218+357G (zl = 0.68466 ± 0.00004, Carilli et al. 1993), which splits the blazar emission into two components, spatially indistinguishable by gamma-ray instruments, but separated by a 10-12 days delay. In July 2014 a flare from QSO B0218+357 was observed by the Fermi-LAT (Large Area Telescope, Atwood et al. 2009, Ackermann et al. 2012), and followed-up by the MAGIC (Major Atmospheric Gamma Imaging Cherenkov) telescopes, a stereoscopic system of two 17m Imaging Atmospheric Cherenkov Telescopes located on La Palma, Canary Islands (Aleksić et al. 2016a, 2016b), during the expected time of arrival of the delayed component of the emission. MAGIC could not observe the leading image due to the Full Moon. The MAGIC and Fermi-LAT observations were accompanied by optical data from KVA telescope at La Palma, and X-ray observations by Swift-XRT (Fig. 1 left). Variability in gamma-rays was of the order of one day, while no variability correlated with gamma-rays was observed at lower energies. The flux ratio of the leading to trailing image in HE gamma-rays was larger than in the flare of QSO B0218+357 observed by Fermi-LAT in 2012 (Cheung et al. 2014). Changes in the observed flux ratio can be caused by gravitational microlensing on individual stars in the host galaxy (Neronov et al. 2015), or by other compact objects like for ex. clumps in giant molecular clouds (Sitarek & Bednarek 2016).
Blazar OJ 287 is one of the best observed extragalactic objects. It's historical light curve goes back to 1890′s. Based on the historical behaviour Sillanpää et al. (1988) showed that OJ 287 displays large periodic outbursts, with a period of 11.7 years. We have monitored OJ 287 intensively for two years, during the OJ-94 project. This project was created for monitoring OJ 287 during its predicted new outburst in 1994. In the data archive we have over 7000 observations on OJ 287, in the radio, infrared and optical bands. This data archive contains the best ever obtained light curves for any extragalactic object. The optical light curve shows continuous variability down to time scales of tens of minutes. The variability observed in OJ 287 can be broken down to (at least) four different categories:
We present high-resolution imaging of the BL Lac objects 1ES 0229+200 (z = 0.14), Markarian 421 (z = 0.031) and the prototype BL Lac (z = 0.069). Our goal is to study the properties of the host galaxies of this enigmatic sources and to compare them with their non-actice counterparts. The observations were carried out with the Nordical Optical Telescope (NOT) at La Palma under sub-arcsecond seeing conditions (FWHM < 0.″8). The surface brightness profiles of the host galaxies were analyzed as described in Bender and Möllenhoff (A&A, 177, 71 (1987)). After masking the disturbing field stars/galaxies isophotes were fitted by ellipses down to 20.5 mag/arccsec2 in Markarian 421, 23.5 mag/arcsec2 in BL Lac and 25.5 mag/arcsec2 in 1ES 0229+200. Additionally, we analyzed the surface brightness profile of the companion of Markarian 421.
The surface brightness profiles of the host galaxies were analyzed as described in Bender and Möllenhoff (A & A, 177, 71 (1987)). After masking the disturbing field stars/galaxies isophotes were fitted by ellipses down to 20.5 mag/arccsec2 in Markarian 421, 23.5 mag/arccsec2 in BL Lac and 25.5 mag/arccsec2 in 1ES 0229+200. Additionally, we analyzed the surface brightness profile of the companion of Markarian 421.
A widely accepted model for BL Lac objects is that they are radio galaxies with a relativistic jet pointing almost directly towards us. But we need a clear trigger mechanism for these jets. One possibility is the close interaction between the BL Lac host and the closeby galaxies (e.g. Heckman et al. 1986). This interaction has been seen many times in the case of quasars (Hutchings et al. 1989) but not so much is known about the close surroundings of the BL Lac objects although there has been some pioneer work like Stickel et al. (1993). The problem has usually been that the images are not deep enough and that the seeing has not been so good. To clarify the situation we have started an observing program to get very deep images in the sub-arcsecond seeing conditions from the whole 1 Jy sample (Stickel et al. 1991) of BL Lac objects. The aims of this study are: 1. to search for very close companions to the BL Lacs, 2. to study the large scale galaxy clustering around the BL Lacs and 3. to study the BL Lac hosts themselves.
Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear. We investigated hippocampal function in depression using functional magnetic resonance imaging (fMRI) and neuropsychological tasks tapping spatial memory function, with complementing measures of hippocampal volume and resting blood flow to aid interpretation.
A total of 20 patients with major depressive disorder (MDD) and a matched group of 20 healthy individuals participated. Participants underwent multimodal magnetic resonance imaging (MRI): fMRI during a spatial memory task, and structural MRI and resting blood flow measurements of the hippocampal region using arterial spin labelling. An offline battery of neuropsychological tests, including several measures of spatial memory, was also completed.
The fMRI analysis showed significant group differences in bilateral anterior regions of the hippocampus. While control participants showed task-dependent differences in blood oxygen level-dependent (BOLD) signal, depressed patients did not. No group differences were detected with regard to hippocampal volume or resting blood flow. Patients showed reduced performance in several offline neuropsychological measures. All group differences were independent of differences in hippocampal volume and hippocampal blood flow.
Functional abnormalities of the hippocampus can be observed in patients with MDD even when the volume and resting perfusion in the same region appear normal. This suggests that changes in hippocampal function can be observed independently of structural abnormalities of the hippocampus in depression.
We have obtained new optical spectra of the radio galaxy 3C 129 and the giant galaxy close to it. From these spectra we deduce a relative radial velocity of 710 km s−1 between the two galaxies. Using the orbit calculations of Byrd & Valtonen (1978) and the new observations we obtain a new value, 3.3 × 1014M⊙, for the mass of the system.
Gametocytes are the specialized form of Plasmodium parasites that are responsible for human-to-mosquito transmission of malaria. Transmission of gametocytes is highly effective, but represents a biomass bottleneck for the parasite that has stimulated interest in strategies targeting the transmission stages separately from those responsible for clinical disease. Studying targets of naturally acquired immunity against transmission-stage parasites may reveal opportunities for novel transmission reducing interventions, particularly the development of a transmission blocking vaccine (TBV). In this review, we summarize the current knowledge on immunity against the transmission stages of Plasmodium. This includes immune responses against epitopes on the gametocyte-infected erythrocyte surface during gametocyte development, as well as epitopes present upon gametocyte activation in the mosquito midgut. We present an analysis of historical data on transmission reducing immunity (TRI), as analysed in mosquito feeding assays, and its correlation with natural recognition of sexual stage specific proteins Pfs48/45 and Pfs230. Although high antibody titres towards either one of these proteins is associated with TRI, the presence of additional, novel targets is anticipated. In conclusion, the identification of novel gametocyte-specific targets of naturally acquired immunity against different gametocyte stages could aid in the development of potential TBV targets and ultimately an effective transmission blocking approach.
In this paper the feasibility to extract the proportion of pigs located in different areas of a pig pen by advanced image analysis technique is explored and discussed for possible applications. For example, pigs generally locate themselves in the wet dunging area at high ambient temperatures in order to avoid heat stress, as wetting the body surface is the major path to dissipate the heat by evaporation. Thus, the portion of pigs in the dunging area and resting area, respectively, could be used as an indicator of failure of controlling the climate in the pig environment as pigs are not supposed to rest in the dunging area. The computer vision methodology utilizes a learning based segmentation approach using several features extracted from the image. The learning based approach applied is based on extended state-of-the-art features in combination with a structured prediction framework based on a logistic regression solver using elastic net regularization. In addition, the method is able to produce a probability per pixel rather than form a hard decision. This overcomes some of the limitations found in a setup using grey-scale information only. The pig pen is a difficult imaging environment because of challenging lighting conditions like shadows, poor lighting and poor contrast between pig and background. In order to test practical conditions, a pen containing nine young pigs was filmed from a top view perspective by an Axis M3006 camera with a resolution of 640×480 in three, 10-min sessions under different lighting conditions. The results indicate that a learning based method improves, in comparison with greyscale methods, the possibility to reliable identify proportions of pigs in different areas of the pen. Pigs with a changed behaviour (location) in the pen may indicate changed climate conditions. Changed individual behaviour may also indicate inferior health or acute illness.
Attentional impairment is a core cognitive feature of major depressive disorder (MDD) and bipolar disorder (BD). However, little is known of the characteristics of response time (RT) distributions from attentional tasks. This is crucial to furthering our understanding of the profile and extent of cognitive intra-individual variability (IIV) in mood disorders.
A computerized sustained attention task was administered to 138 healthy controls and 158 patients with a mood disorder: 86 euthymic BD, 33 depressed BD and 39 medication-free MDD patients. Measures of IIV, including individual standard deviation (iSD) and coefficient of variation (CoV), were derived for each participant. Ex-Gaussian (and Vincentile) analyses were used to characterize the RT distributions into three components: mu and sigma (mean and standard deviation of the Gaussian portion of the distribution) and tau (the ‘slow tail’ of the distribution).
Compared with healthy controls, iSD was increased significantly in all patient samples. Due to minimal changes in average RT, CoV was only increased significantly in BD depressed patients. Ex-Gaussian modelling indicated a significant increase in tau in euthymic BD [Cohen's d = 0.39, 95% confidence interval (CI) 0.09–0.69, p = 0.011], and both sigma (d = 0.57, 95% CI 0.07–1.05, p = 0.025) and tau (d = 1.14, 95% CI 0.60–1.64, p < 0.0001) in depressed BD. The mu parameter did not differ from controls.
Increased cognitive variability may be a core feature of mood disorders. This is the first demonstration of differences in attentional RT distribution parameters between MDD and BD, and BD depression and euthymia. These data highlight the utility of applying measures of IIV to characterize neurocognitive variability and the great potential for future application.
We explore the connection between the black hole mass and its relativistic jet for a sample of radio-loud AGN (z < 1), in which the relativistic jet parameters are well estimated by means of long term monitoring with the 14m Metsähovi millimeter wave telescope and the Very Long Base-line Array (VLBA). NIR host galaxy images taken with the NOTCam on the Nordic Optical Telescope (NOT) and retrieved from the 2MASS all-sky survey allowed us to perform a detailed surface brightness decomposition of the host galaxies in our sample and to estimate reliable black hole masses via their bulge luminosities. We present early results on the correlations between black hole mass and the relativistic jet parameters. Our preliminary results suggest that the more massive the black hole is, the faster and the more luminous jet it produces.
We examined whether conversion to dementia can be predicted by self-reported olfactory impairment and/or by an inability to identify odors. Common forms of dementia involve an impaired sense of smell, and poor olfactory performance predicts cognitive decline among the elderly. We followed a sample of 1529 participants, who were within a normal range of overall cognitive function at baseline, over a 10-year period during which 159 were classified as having a dementia disorder. Dementia conversion was predicted from demographic variables, Mini-Mental State Examination score, and olfactory assessments. Self-reported olfactory impairment emerged as an independent predictor of dementia. After adjusting for effects of other predictors, individuals who rated their olfactory sensitivity as “worse than normal” were more likely to convert to dementia than those who reported normal olfactory sensitivity (odds ratio [OR] = 2.17; 95% confidence interval [CI] [1.40, 3.37]). Additionally, low scores on an odor identification test also predicted conversion to dementia (OR per 1 point increase = 0.89; 95% CI [0.81, 0.98]), but these two effects were additive. We suggest that assessing subjective olfactory complaints might supplement other assessments when evaluating the risk of conversion to dementia. Future studies should investigate which combination of olfactory assessments is most useful in predicting dementia conversion. (JINS, 2014, 20, 1–9)
This study examines if lactase non-persistent (LNP) children and adolescents differ from those who are lactase persistent (LP) as regards milk avoidance and Ca intake. We also studied potential differences in anthropometric features related to obesity, and examined if milk avoidance is associated with lactase-persistence status. Additionally, we aimed to determine if heterozygous subjects showed an intermediary phenotype as regards Ca intake. Furthermore, we tested if LP and LNP influence vitamin D intake. The European Youth Heart Study is an ongoing international, multi-centre cohort study primarily designed to address CVD risk factors. Children (n 298, mean age 9·6 years) and adolescents (n 386, mean age 15·6 years) belonging to the Swedish part of the European Youth Heart Study were genotyped for the LCT-13910 C > T polymorphism. Mendelian randomisation was used. Milk avoidance was significantly more common in LNP adolescents (OR 3·2; 95% CI 1·5, 7·3). LP subjects had higher milk consumption (P < 0·001). Accordingly, energy consumption derived from milk and Ca intake was lower in LNP (P < 0·05 and P < 0·001, respectively). Heterozygous subjects did not show an intermediary phenotype concerning milk consumption. LP or LNP status did not affect vitamin D intake or anthropometric variables. LNP in children and adolescents is associated with reduced intake of milk and some milk-product-related nutritional components, in particular Ca. This reduced intake did not affect the studied anthropometric variables, indicators of body fat or estimated vitamin D intake. However, independently of genotype, age and sex, daily vitamin D intake was below the recommended intakes. Milk avoidance among adolescents but not children was associated with LNP.
To examine the use of vitamin D supplements during infancy among the participants in an international infant feeding trial.
Information about vitamin D supplementation was collected through a validated FFQ at the age of 2 weeks and monthly between the ages of 1 month and 6 months.
Infants (n 2159) with a biological family member affected by type 1 diabetes and with increased human leucocyte antigen-conferred susceptibility to type 1 diabetes from twelve European countries, the USA, Canada and Australia.
Daily use of vitamin D supplements was common during the first 6 months of life in Northern and Central Europe (>80 % of the infants), with somewhat lower rates observed in Southern Europe (>60 %). In Canada, vitamin D supplementation was more common among exclusively breast-fed than other infants (e.g. 71 % v. 44 % at 6 months of age). Less than 2 % of infants in the USA and Australia received any vitamin D supplementation. Higher gestational age, older maternal age and longer maternal education were study-wide associated with greater use of vitamin D supplements.
Most of the infants received vitamin D supplements during the first 6 months of life in the European countries, whereas in Canada only half and in the USA and Australia very few were given supplementation.
We present Monte Carlo based calculations of transport parameters useful in the simulation of III-nitride and SiC based devices. The calculations are performed using a full band ensemble Monte Carlo model that includes numerical formulations of the phonon scattering rates and impact ionization transition rates. Calculations are made for the wurtzite and zincblende phases of GaN, the wurtzite phase of InN, and the 3C (cubic) and 4H phases of SiC. The basic transport parameters determined are saturation drift velocity, and the ionization coefficients as a function of applied electric field. Results from the various materials are finally compared.