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The aim of this study was to investigate the association between daily selenium (Se) intake and postpartum weight retention (PPWR) among Chinese lactating women, and the impact of their Se nutritional status on infants’ physical development. Se contents in breast milk and plasma collected from total 264 lactating Chinese women at the 42nd day postpartum were analyzed with ICP-MS. Daily Se intake was calculated based on plasma Se concentration. The dietary data of 24-hour record on 3 consecutive days was collected. Infant’s growth status was evaluated with WHO standards by Z-scores. Linear regression analyses and multinomial logistic regression were conducted to examine the impact of Se disequilibrium (including other factors) on PPWR and growth of infants, respectively. The results indicated that: 1) The daily Se intake of the subjects was negatively with their PPWR (B = -0.002, 95% CI -0.003, 0.000, P=0.039). 2) Both insufficient Se daily intake (B=-0.001, OR 95% CI 0.998, 1.000, P=0.014) and low level of Se in milk (B=-0.025, OR 95% CI 0.951, 0.999, P=0.021) had potential associations with their infants’ wasting, and low level of Se in milk (B=-0.159, OR 95% CI 0.743, 0.980, P=0.024) had a significant association with their infants’ overweight. In conclusion, the insufficient Se nutritional status of lactating Chinese women was firstly found as one possible influencing factor of their PPWR as well as low physical development of their offsprings.
We prove that, for any $t \ge 3$, there exists a constant c = c(t) > 0 such that any d-regular n-vertex graph with the second largest eigenvalue in absolute value λ satisfying $\lambda \le c{d^{t - 1}}/{n^{t - 2}}$ contains vertex-disjoint copies of kt covering all but at most ${n^{1 - 1/(8{t^4})}}$ vertices. This provides further support for the conjecture of Krivelevich, Sudakov and Szábo (Combinatorica24 (2004), pp. 403–426) that (n, d, λ)-graphs with n ∈ 3ℕ and $\lambda \le c{d^2}/n$ for a suitably small absolute constant c > 0 contain triangle-factors. Our arguments combine tools from linear programming with probabilistic techniques, and apply them in a certain weighted setting. We expect this method will be applicable to other problems in the field.
The South China Block is one of the largest continental blocks located on the East Asian continent. The early Palaeozoic Wuyi–Yunkai orogen of the South China Block (known as the Caledonian orogen in Europe) is a major orogenic belt in East Asia and represents the first episode of extensive crustal reworking since Neoproterozoic time. Although this orogen is key to deciphering the formation and evolution of the South China Block, details about the orogen remain poorly defined. The Songshutang and Wushitou ultramafic–mafic units in southern Jiangxi Province, South China, have 206Pb–238U ages of c. 437 Ma, suggesting a Silurian formation age. All the Songshutang and Wushitou ultramafic–mafic rocks show relatively flat chondrite-normalized rare earth element patterns, depletions in Nb, Ta, Zr, Hf and Ti, and low ϵNd(t) values from −9.12 to −5.49 with negative zircon ϵHf(t) values from −10.84 to −2.58, resembling a typical arc magma affinity. Geochemical and isotopic data indicate that the newly identified ultramafic–mafic rocks, along with the reported Silurian mafic rocks in South China, possibly originated from the similar partial melting of an ancient subducted slab, fluid/sediment and metasomatized lithospheric mantle with varying degrees of fractional crystallization. In conjunction with other records of magmatism and metamorphism in South China, a late-orogenic extensional event led to the melting of the sub-continental lithospheric mantle in Silurian time and generated ultramafic–mafic rocks with a limited distribution along the Wuyi–Yunkai orogen and widespread late-orogenic granitic plutons in the South China Block.
The upsurge in the number of people affected by the COVID-19 is likely to lead to increased rates of emotional trauma and mental illnesses. This article systematically reviewed the available data on the benefits of interventions to reduce adverse mental health sequelae of infectious disease outbreaks, and to offer guidance for mental health service responses to infectious disease pandemic. PubMed, Web of Science, Embase, PsycINFO, WHO Global Research Database on infectious disease, and the preprint server medRxiv were searched. Of 4278 reports identified, 32 were included in this review. Most articles of psychological interventions were implemented to address the impact of COVID-19 pandemic, followed by Ebola, SARS, and MERS for multiple vulnerable populations. Increasing mental health literacy of the public is vital to prevent the mental health crisis under the COVID-19 pandemic. Group-based cognitive behavioral therapy, psychological first aid, community-based psychosocial arts program, and other culturally adapted interventions were reported as being effective against the mental health impacts of COVID-19, Ebola, and SARS. Culturally-adapted, cost-effective, and accessible strategies integrated into the public health emergency response and established medical systems at the local and national levels are likely to be an effective option to enhance mental health response capacity for the current and for future infectious disease outbreaks. Tele-mental healthcare services were key central components of stepped care for both infectious disease outbreak management and routine support; however, the usefulness and limitations of remote health delivery should also be recognized.
A k-uniform tight cycle
$C_s^k$
is a hypergraph on s > k vertices with a cyclic ordering such that every k consecutive vertices under this ordering form an edge. The pair (k, s) is admissible if gcd (k, s) = 1 or k / gcd (k,s) is even. We prove that if
$s \ge 2{k^2}$
and H is a k-uniform hypergraph with minimum codegree at least (1/2 + o(1))|V(H)|, then every vertex is covered by a copy of
$C_s^k$
. The bound is asymptotically sharp if (k, s) is admissible. Our main tool allows us to arbitrarily rearrange the order in which a tight path wraps around a complete k-partite k-uniform hypergraph, which may be of independent interest.
For hypergraphs F and H, a perfect F-tiling in H is a spanning collection of vertex-disjoint copies of F. For
$k \ge 3$
, there are currently only a handful of known F-tiling results when F is k-uniform but not k-partite. If s ≢ 0 mod k, then
$C_s^k$
is not k-partite. Here we prove an F-tiling result for a family of non-k-partite k-uniform hypergraphs F. Namely, for
$s \ge 5{k^2}$
, every k-uniform hypergraph H with minimum codegree at least (1/2 + 1/(2s) + o(1))|V(H)| has a perfect
$C_s^k$
-tiling. Moreover, the bound is asymptotically sharp if k is even and (k, s) is admissible.
Studies have indicated that psychological stress impairs human fertility and that various stressors can induce apoptosis of testicular cells. However, the mechanisms by which psychological stress on males reduces semen quality and stressors induce apoptosis in testicular cells are largely unclear. Using a psychological (restraint) stress mouse model, we tested whether male psychological stress triggers apoptosis of spermatozoa and spermatogenic cells through activating tumour necrosis factor (TNF)-α signalling. Wild-type or TNF-α−/− male mice were restrained for 48 h before examination for apoptosis and expression of TNF-α and TNF receptor 1 (TNFR1) in spermatozoa, epididymis, seminiferous tubules and spermatogenic cells. The results showed that male restraint significantly decreased fertilization rate and mitochondrial membrane potential, while increasing levels of malondialdehyde, active caspase-3, TNF-α and TNFR1 in spermatozoa. Male restraint also increased apoptosis and expression of TNF-α and TNFR1 in caudae epididymides, seminiferous tubules and spermatogenic cells. Sperm quality was also significantly impaired when spermatozoa were recovered 35 days after male restraint. The restraint-induced damage to spermatozoa, epididymis and seminiferous tubules was significantly ameliorated in TNF-α−/− mice. Furthermore, incubation with soluble TNF-α significantly reduced sperm motility and fertilizing potential. Taken together, the results demonstrated that male psychological stress induces apoptosis in spermatozoa and spermatogenic cells through activating the TNF-α system and that the stress-induced apoptosis in spermatogenic cells can be translated into impaired quality in future spermatozoa.
Octapyrgites elongatus n. gen. n. sp., a relatively rare, tetraradial olivooid (Cnidaria, Medusozoa), is described from Bed 5 of the Yanjiahe Formation (Cambrian Stage 2) near Yichang, China. Although similar to Olivooides and Quadrapyrgites from the Fortunian Stage in consisting of a partially corrugated (longitudinal) periderm with a quadrate (transverse) apical portion and V-shaped apertural lobes, O. elongatus is substantially larger than other olivooids. The elongate apical region of O. elongatus is similar to four-sided Anaconularia anomala (Barrande, 1867), though with a flat tip that may have been an adaption for a sessile mode of life. As in other olivooids, embryonic development in O. elongatus may have been direct. Last, the paucity of olivooids and the absence of pentaradial cnidarians and carinachitids in Cambrian Stage 2 indicate a marked decline in the disparity of cnidarians near the Fortunian–Cambrian Age 2 boundary, when by contrast bilaterians underwent rapid diversification.
The microbiota–gut–brain axis, especially the microbial tryptophan (Trp) biosynthesis and metabolism pathway (MiTBamp), may play a critical role in the pathogenesis of major depressive disorder (MDD). However, studies on the MiTBamp in MDD are lacking. The aim of the present study was to analyze the gut microbiota composition and the MiTBamp in MDD patients.
Methods
We performed shotgun metagenomic sequencing of stool samples from 26 MDD patients and 29 healthy controls (HCs). In addition to the microbiota community and the MiTBamp analyses, we also built a classification based on the Random Forests (RF) and Boruta algorithm to identify the gut microbiota as biomarkers for MDD.
Results
The Bacteroidetes abundance was strongly reduced whereas that of Actinobacteria was significantly increased in the MDD patients compared with the abundance in the HCs. Most noteworthy, the MDD patients had increased levels of Bifidobacterium, which is commonly used as a probiotic. Four Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologies (KOs) (K01817, K11358, K01626, K01667) abundances in the MiTBamp were significantly lower in the MDD group. Furthermore, we found a negative correlation between the K01626 abundance and the HAMD scores in the MDD group. Finally, RF classification at the genus level can achieve an area under the receiver operating characteristic curve of 0.890.
Conclusions
The present findings enabled a better understanding of the changes in gut microbiota and the related Trp pathway in MDD. Alterations of the gut microbiota may have the potential as biomarkers for distinguishing MDD patients form HCs.
Given two k-graphs (k-uniform hypergraphs) F and H, a perfect F-tiling (or F-factor) in H is a set of vertex-disjoint copies of F that together cover the vertex set of H. For all complete k-partite k-graphs K, Mycroft proved a minimum codegree condition that guarantees a K-factor in an n-vertex k-graph, which is tight up to an error term o(n). In this paper we improve the error term in Mycroft’s result to a sublinear term that relates to the Turán number of K when the differences of the sizes of the vertex classes of K are co-prime. Furthermore, we find a construction which shows that our improved codegree condition is asymptotically tight in infinitely many cases, thus disproving a conjecture of Mycroft. Finally, we determine exact minimum codegree conditions for tiling K(k)(1, … , 1, 2) and tiling loose cycles, thus generalizing the results of Czygrinow, DeBiasio and Nagle, and of Czygrinow, respectively.
Intestinal barrier inflammatory damage is commonly accompanied by hypoxia. The hypothesis that dietary Acanthopanax senticosus polysaccharides (ASPS) might modulate the hypoxia-inducible factor-1α (HIF-1α) signalling pathway and contribute to attenuate intestinal injury was tested in lipopolysaccharide (LPS)-challenged piglets. Thirty-six weaned pigs were randomly allocated to one of the following three groups: (1) basal diet + saline challenge; (2) basal diet + LPS challenge; (3) basal diet with 800 mg/kg ASPS + LPS challenge. LPS was injected at 15, 18 and 21 d, and intestinal sections were sampled following blood collection at 21 d . The results showed ASPS reversed (P < 0·05) LPS-induced decrease in average daily feed intake and rise (P < 0·05) of diarrhoea incidence and index. Biochemical index reflecting gut barrier damage and function involving ileal pro-inflammatory cytokines (TNF-α and IL-1β) and enzyme activity (diamine oxidase and lactase), as well as circulatory d-xylose, was normalised (P < 0·05) in LPS-challenged piglets receiving ASPS. ASPS also ameliorated intestinal morphological deterioration of LPS-challenged piglets, proved by elevated ileal villus height (P < 0·05) and improved appearance of epithelial villus and tight junction ultrastructure. Moreover, ASPS prevented LPS-induced amplification of inflammatory mediators, achieved by depressed ileal mRNA abundance of TNF-α, inducible NO synthase and IL-1β concentration. Importantly, ileal protein expressions of HIF-1α, cyclo-oxygenase-2 (COX-2) and NFκB p65 were also suppressed with ASPS administration (P < 0·05). Collectively, these results suggest the improvement of mucosal inflammatory damage and diarrhoea in immune stress piglets is possibly associated with a novel finding where HIF-1α/COX-2 pathway down-regulation is involved in NFκB p65-inducible releasing of inflammatory cytokines by dietary ASPS.
Underground Nuclear Astrophysics in China (JUNA) will take the advantage of the ultra-low background in Jinping underground lab. High current accelerator with an ECR source and detectors were commissioned. JUNA plans to study directly a number of nuclear reactions important to hydrostatic stellar evolution at their relevant stellar energies. At the first period, JUNA aims at the direct measurements of 25Mg(p,γ)26 Al, 19F(p,α) 16 O, 13C(α, n) 16O and 12C(α,γ) 16O near the Gamow window. The current progress of JUNA will be given.
AlMg alloys have widespread industrial applications. Grain refinement techniques have been frequently used to achieve high strength in these alloys. Here, we report on the fabrication of epitaxial co-sputtered AlMg thin films with high-density growth twins. The microstructure evolution with varying Mg composition has been characterized. Nanoindentation and in-situ micropillar compression tests show that the strength of AlMg alloys increases with increasing Mg composition. The flow stress of epitaxial nanotwinned Al–10 at.% Mg thin film exceeds 800 MPa. The modified Hall–Petch plots incorporating the solid solution strengthening effect suggest that, compared to high angle grain boundaries, incoherent twin boundaries are equivalent barriers to the transmission of dislocations in nanotwinned AlMg alloys.
As a promising new way to generate a controllable strong magnetic field, laser-driven magnetic coils have attracted interest in many research fields. In 2013, a kilotesla level magnetic field was achieved at the Gekko XII laser facility with a capacitor–coil target. A similar approach has been adopted in a number of laboratories, with a variety of targets of different shapes. The peak strength of the magnetic field varies from a few tesla to kilotesla, with different spatio-temporal ranges. The differences are determined by the target geometry and the parameters of the incident laser. Here we present a review of the results of recent experimental studies of laser-driven magnetic field generation, as well as a discussion of the diagnostic techniques required for such rapidly changing magnetic fields. As an extension of the magnetic field generation, some applications are discussed.
We present laboratory measurement and theoretical analysis of silicon K-shell lines in plasmas produced by Shenguang II laser facility, and discuss the application of line ratios to diagnose the electron density and temperature of laser plasmas. Two types of shots were carried out to interpret silicon plasma spectra under two conditions, and the spectra from 6.6 Å to 6.85 Å were measured. The radiative-collisional code based on the flexible atomic code (RCF) is used to identify the lines, and it also well simulates the experimental spectra. Satellite lines, which are populated by dielectron capture and large radiative decay rate, influence the spectrum profile significantly. Because of the blending of lines, the traditional
$G$
value and
$R$
value are not applicable in diagnosing electron temperature and density of plasma. We take the contribution of satellite lines into the calculation of line ratios of He-
$\unicode[STIX]{x1D6FC}$
lines, and discuss their relations with the electron temperature and density.
Astrophysical collisionless shocks are amazing phenomena in space and astrophysical plasmas, where supersonic flows generate electromagnetic fields through instabilities and particles can be accelerated to high energy cosmic rays. Until now, understanding these micro-processes is still a challenge despite rich astrophysical observation data have been obtained. Laboratory astrophysics, a new route to study the astrophysics, allows us to investigate them at similar extreme physical conditions in laboratory. Here we will review the recent progress of the collisionless shock experiments performed at SG-II laser facility in China. The evolution of the electrostatic shocks and Weibel-type/filamentation instabilities are observed. Inspired by the configurations of the counter-streaming plasma flows, we also carry out a novel plasma collider to generate energetic neutrons relevant to the astrophysical nuclear reactions.
Given hypergraphs F and H, an F-factor in H is a set of vertex-disjoint copies of F which cover all the vertices in H. Let K−4 denote the 3-uniform hypergraph with four vertices and three edges. We show that for sufficiently large n ∈ 4ℕ, every 3-uniform hypergraph H on n vertices with minimum codegree at least n/2−1 contains a K−4-factor. Our bound on the minimum codegree here is best possible. It resolves a conjecture of Lo and Markström [15] for large hypergraphs, who earlier proved an asymptotically exact version of this result. Our proof makes use of the absorbing method as well as a result of Keevash and Mycroft [11] concerning almost perfect matchings in hypergraphs.
The resolution of the electron microscope is now largely limited by the performance of its electron source when various aberrations in the electron imaging system, especially spherical aberrations, are corrected. A nanowire tip could be an ideal point electron source, where electrons are emitted from a small physical area. In this article, we review recent advances in electric-field-induced electron emission using a single nanowire, specifically, single-crystalline lanthanum hexaboride (LaB6) nanowire, compared to the state-of-the-art contemporary tungsten cold-field electron emitter W(310) as well as single atom tip and single-carbon nanotube emitters. Owing to its low work function, improved emission stability, and high emission brightness, the LaB6 nanowire as a cold-field-emission electron source offers a new and exciting opportunity for developing the next generation of electron microscopes.
Let C63 be the 3-uniform hypergraph on {1, . . ., 6} with edges 123,345,561, which can be seen as the analogue of the triangle in 3-uniform hypergraphs. For sufficiently large n divisible by 6, we show that every n-vertex 3-uniform hypergraph H with minimum codegree at least n/3 contains a C63-factor, that is, a spanning subhypergraph consisting of vertex-disjoint copies of C63. The minimum codegree condition is best possible. This improves the asymptotic result obtained by Mycroft and answers a question of Rödl and Ruciński exactly.
We test the hypothesis that investment constraints in delegated portfolio management may distort demand for stocks, leading to price underreaction to news and stock return predictability. We find that institutions tend not to buy more of a stock with good news that they already overweight; they are reluctant to sell a stock with bad news that they already underweight. Stocks with good news overweighted by institutions subsequently significantly outperform stocks with bad news underweighted by institutions. The impact of institutional investment constraints sheds new light on asset pricing anomalies such as stock price momentum and post–earnings announcement drift.
Spatial indexing technology is widely used in Geographic Information Systems (GIS) and spatial databases. As a data retrieval technology, spatial indexing is becoming increasingly important in the big-data age. The purpose of this study is to propose a unified indexing strategy for the mixed data of a future marine GIS. First, data organisation of the system is described. Second, the display condition of each type of data is introduced. These conditions are the basis for the construction of a unified indexing structure. Third, a unified indexing structure for mixed data is presented. The construction process and the search method of the indexing structure are described. Finally, we implement the indexing strategy in our system “Automotive Intelligent Chart Three-dimensional Electronic Chart Display and Information Systems” (AIC 3D ECDIS). Our strategy can provide fast and integrated data retrieval. The spatial indexing strategy we propose breaks through the limitation of data types in our system. It can also be applied in other GIS systems. With the advent of the big-data age, mixed data indexing will become more and more important.