To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The increased life expectancy in people with severe and persistent psychiatric illness, such as schizophrenia or bipolar disorder, has been predicted to substantially affect mental healthcare system (Bartels et al., 2002) that must adapt to meet the needs of older adults (Jeste et al., 1999). Development of specialized geriatric psychiatry services is thus needed.
Autobiographical memory retrieval is impaired in schizophrenia.
To determine the neural basis of this impairment.
Thirteen patients with schizophrenia and 14 healthy controls performed an autobiographical memory retrieval task based on cue words during functional magnetic resonance imaging. Patients were selected on the basis of their ability to perform the task and all participants received training.
Although patients and controls activated a similar brain network during autobiographical memory retrieval, patients displayed decreased activation in several of these regions, including the anterior cingulate cortex, left lateral prefrontal cortex, right cerebellum and ventral tegmental area (k ≥ 10, P < 0.001, uncorrected). In addition, activation of the caudate nuclei was negatively correlated with retrieval performance in controls but positively correlated with performance in patients.
The autobiographical memory retrieval brain network is impaired in schizophrenia. Patients with schizophrenia display decreased activation of the cognitive control network during retrieval, possibly due to aberrant functioning of the dorsal striatum.
The reminiscence bump corresponds to a marked increase in
autobiographical memories of events that occurred when normal people were
aged 10 to 30 years, a critical period for the formation of identity. The
reminiscence bump was studied in 27 patients diagnosed with schizophrenia
and 27 control participants. They were asked to recall 20 specific
autobiographical events that had occurred during their lifetime and to
indicate the subjective states of awareness associated with the recalled
memories using the Remember/Know procedure. Finally, participants were
asked to state whether recalled memories related to private or public
events. Patients diagnosed with schizophrenia recalled less specific
memories than controls and exhibited an earlier reminiscence bump. They
recalled more public, and less private events than controls, and they gave
fewer Remember responses. The reminiscence bump peaked in the 16 to
25-year period for patients and the 21 to 25-year period for controls.
These findings indicate that patients diagnosed with schizophrenia exhibit
an early and abnormal reminiscence bump, with an impairment of conscious
recollection associated with memories highly relevant to personal
identity. They suggest that schizophrenia is associated with an impairment
of autobiographical memories of events that had occurred during the last
stage of personal identity development (JINS, 2007, 13,
Email your librarian or administrator to recommend adding this to your organisation's collection.