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La stimulation magnétique transcrânienne répétitive (SMTr) appliquée sur le cortex préfrontal dorso-latéral (CPFDL) a prouvé son efficacité dans le traitement de la dépression résistante . En plus d’une amélioration sur la symptomatologie, des études rapportent des effets positifs sur le fonctionnement cognitif , dont la mémoire de travail. Cependant, cet effet ne semble pas être retrouvé chez des sujets sains  lors d’une tâche de N-back sans leurre. L’objectif de notre étude est donc d’évaluer l’impact de la SMTr sur le CPFDL, région plus sensible à une tâche de N-back avec leurre .
Une étude randomisée en double insu a été menée chez 30 participants sains. Une stimulation de type iTBS (intermittent theta burst stimulation) a été effectuée pendant 5 jours à raison de 2 séances/jour appliquée au niveau du CPFDL gauche ciblé par neuro-navigation sur les coordonnées MNI (X, Y, Z = –50,30,36). Nous avons observé l’impact de la SMTr sur le comportement des participants durant la tâche de N-back. Pour cela, les participants ont effectué cette tâche, composée de blocs de 0-back, 3-back et 3-back contenant des leurres, lors de deux sessions d’IRMf (une avant et une après la semaine de stimulation active ou placebo). La performance, le temps de réaction ainsi que les données d’imageries ont été recueillis.
Les 2 groupes ne montrent pas de différence au niveau de l’âge ou du genre. Au niveau comportemental, les premières analyses sur la performance ainsi que sur le temps de réaction ne montrent pas d’effet d’interaction Groupe (actif/placebo) * Temps (avant/après SMTr). Au niveau des données de neuro-imagerie, une analyse d’interaction Groupe * Temps en prenant en compte la condition leurre nous permettra de mieux comprendre l’impact de la SMTr sur la mémoire de travail impliquant le CPFDL.
Currently, 25-30% of Obsessive-compulsive disorder (OCD) patients are considered to be resistant to conventional therapies (cognitive-behavioral therapy and medications including selective inhibitors of reuptake of serotonin and clomipramine). Among alternative therapeutic strategies for theses refractory patients, repetitive Transcranial Magnetic Stimulation (rTMS) has been proposed (Greenberg et al., 1997). Few regions were choice for OCD patients and one of them could be a promising target: the Supplementary Motor Area (SMA). The aim of this project focuses on evaluate the SMA as a promising region to treat OCD patients. Forty patients were include in this double blind study, each received 20 session of rTMS (1 session / day) for 4 weeks with active or sham coil. rTMS parameters consisted of 1500 pulses/d, at 1 Hz, 5 trains of 5 min with an interval inter- stimulus of 2 min and 100% of motor threshold. To localize the SMA, neuronavigation was based on anatomical Magnetic Resonance Imaging (MRI) using Brainsight software. The therapeutic effect of rTMS will be assessed through a psychological evaluation and a task performed in functional MRI, before and after therapeutic: The Eriksen’s task. Its objective is to evaluate cerebral metabolism’s modifications during a simple task likely to recruit the error detection system implicating the Anterior Cingulate Cortex without inducing obsessive-compulsive symptoms. This modification were correlated with clinical and cognitive assessment and behavioral results of the Eriksen task
The geographical term “Southeast Asia” dates from the 1930s, and came to denote a topic for academic studies in the early days of the Cold War. As such, it includes Vietnam, Cambodia, Laos, Indochina, Thailand, Myanmar, Malaysia, Brunei, and the Philippines. Southeast Asia has become thoroughly incorporated in the global economy over the past 150 years; first, as a producer of commodities, and later, as a supplier of cheap garments and electronic components. Under Dutch colonialism and British hegemony—the latter established by the conquest of Burma and the imposition of free trade on Siam and the Philippines in the 1850s—Southeast Asia was turned into a key provider of commodities for the industrializing countries. During high colonialism, from 1870 to 1930, the region became increasingly intertwined, via Singapore as the central port and through the role of mainland Southeast Asia as the rice basket for the plantations of maritime Southeast Asia. After the Second World War, the region was the world's most violent frontier of containment for communist expansion. In recent decades, Southeast Asia has become integrated in global commodity chains as a producer of cheap industrial goods, often as a subcontractor for more advanced economies, such as those of Hong Kong, Korea, Taiwan, and later on, Southeast China.
The Square Kilometre Array (SKA) is a planned large radio interferometer designed to operate over a wide range of frequencies, and with an order of magnitude greater sensitivity and survey speed than any current radio telescope. The SKA will address many important topics in astronomy, ranging from planet formation to distant galaxies. However, in this work, we consider the perspective of the SKA as a facility for studying physics. We review four areas in which the SKA is expected to make major contributions to our understanding of fundamental physics: cosmic dawn and reionisation; gravity and gravitational radiation; cosmology and dark energy; and dark matter and astroparticle physics. These discussions demonstrate that the SKA will be a spectacular physics machine, which will provide many new breakthroughs and novel insights on matter, energy, and spacetime.
We investigate how the properties of spiral arms relate to other fundamental galaxy properties. To this end, we use previously published measurements of those properties, and our own measurements of arm-interarm luminosity contrasts for a large sample of galaxies, using 3.6μm images from the Spitzer Survey of Stellar Structure in Galaxies. Flocculent galaxies are clearly distinguished from other spiral arm classes, especially by their lower stellar mass and surface density. Multi-armed and grand-design galaxies are similar in most of their fundamental parameters, excluding some bar properties and the bulge-to-total luminosity ratio. Based on these results, we discuss dense, classical bulges as a necessary condition for standing spiral wave modes in grand-design galaxies. We further find a strong correlation between bulge-to-total ratio and bar contrast, and a weaker correlation between arm and bar contrasts.
Previous research has shown that in a minority–majority language context, the quantity of language input at home is more important for the development of the minority language than for the development of the majority language. In the current study, we examined whether the same holds true for the frequency of specific language activities at home. In a group of five- and six-year-old Frisian–Dutch bilingual children (n = 120), we investigated to what extent vocabulary and morphology knowledge were predicted by reading activities, watching TV, and story-telling activities in both languages. The results showed that reading in Frisian predicted both Frisian vocabulary and morphology, while reading in Dutch only predicted Dutch vocabulary. This shows that reading at home is most important for the development of the minority language. This especially holds true for the acquisition of Frisian morphology, a domain that is known to be vulnerable in language acquisition.
The essays in this volume provide a new perspective on the history of convicts and penal colonies. They demonstrate that the nineteenth and twentieth centuries were a critical period in the reconfiguration of empires, imperial governmentality, and punishment, including through extensive punitive relocation and associated extractive labour. Ranging across the global contexts of Africa, Asia, Australasia, Japan, the Americas, the Pacific, Russia, and Europe, and exploring issues of criminalization, political repression, and convict management alongside those of race, gender, space, and circulation, this collection offers a perspective from the colonies that radically transforms accepted narratives of the history of empire and the history of punishment. In this introduction, we argue that a colony-centred perspective reveals that, during a critical period in world history, convicts and penal colonies created new spatial hierarchies, enabled the incorporation of territories into spheres of imperial influence, and forged new connections and distinctions between “metropoles” and “colonies”. Convicts and penal colonies enabled the formation of expansive and networked global configurations and processes, a factor hitherto unappreciated in the literature.
Among the roughly 150,000 soldiers sent to the Dutch East Indies between 1815 and 1914, the Luxembourg contingent made up a tiny minority of just 1,075 men. Based upon extensive research into their careers, data on these soldiers provide further clues to understanding what drove Europe’s young men to become colonial soldiers. The results of this national case study will be compared with earlier investigations by Bossenbroek and Bosma on recruits for the Dutch colonial army. Similar to the Dutch soldiers, their Luxembourg counterparts had a predominantly urban provenance. However, in contrast to the Dutch, they did not have a strong military background, and it appears that fewer Luxembourgers stayed behind in the Dutch East Indies after their tour of duty. They were more attracted by the payments that the recruiters doled out in advance, particularly at a time of economic crisis, than in a career in the tropics.
The ability to predict upper respiratory infections (URI), lower respiratory infections (LRI), and gastrointestinal tract infections (GI) in independently living older persons would greatly benefit population and individual health. Social network parameters have so far not been included in prediction models. Data were obtained from The Maastricht Study, a population-based cohort study (N = 3074, mean age (±s.d.) 59.8 ± 8.3, 48.8% women). We used multivariable logistic regression analysis to develop prediction models for self-reported symptomatic URI, LRI, and GI (past 2 months). We determined performance of the models by quantifying measures of discriminative ability and calibration. Overall, 953 individuals (31.0%) reported URI, 349 (11.4%) LRI, and 380 (12.4%) GI. The area under the curve was 64.7% (95% confidence interval (CI) 62.6–66.8%) for URI, 71.1% (95% CI 68.4–73.8) for LRI, and 64.2% (95% CI 61.3–67.1%) for GI. All models had good calibration (based on visual inspection of calibration plot, and Hosmer–Lemeshow goodness-of-fit test). Social network parameters were strong predictors for URI, LRI, and GI. Using social network parameters in prediction models for URI, LRI, and GI seems highly promising. Such parameters may be used as potential determinants that can be addressed in a practical intervention in older persons, or in a predictive tool to compute an individual's probability of infections.
Relations between histories, sources and preservation problematics are explored by evaluating how Dutch electroacoustic musical life is discussed in international histories of electronic music. Some Dutch cases consisting of different generations of interdisciplinary, live, performance-based electroacoustic work are discussed: the work of Dick Raaijmakers, Michel Waisvisz and Huba de Graaff. These cases point to some important aspects of preservation and the formation of histories. An emphasis in electronic music histories on technology and on technological innovation comes at the expense of information on the musical and artistic aspects. For greater interest in musical aspects, it is crucial to have more access to the music itself. The works and practices of Dick Raaijmakers, Michel Waisvisz and Huba de Graaff seem to resist documentation, ontologically and practically but, on the other hand, there is a desire for its documentation and dissemination. For their work, preservation means: making something new while being faithful to the past. It is therefore that I propose to regard preservation as performance. This music only remains alive when we are not solely interested in linear innovation, but in a profound relation with the past, in reworking the past.
In this short write-up, I will concentrate on a few topics of interest. In the 1970s I found very extended HI disks in galaxies such as NGC 5055 and NGC 2841, out to 2 - 2.5 times the Holmberg radius. Since these galaxies are warped, a “tilted ring model” allows rotation curves to be derived, and evidence for dark matter to be found. The evaluation of the amount of dark matter is hampered by a disk-halo degeneracy, which can possibly be broken by observations of velocity dispersions in both the MgI region and the CaII region.
We present a pilot study on the nearby massive galaxy NGC 1291, in which we aim to constrain the dark matter in the inner regions, by obtaining a dynamical determination of the disc mass-to-light ratio (M/L). To this aim, we model the bar-induced dust lanes in the galaxy, using hydrodynamic gas response simulations. The models have three free parameters, the M/L of the disc, the bar pattern speed and the disc height function. We explore the parameter space to find the best fit models, i.e. those in which the morphology of the shocks in the gas simulations matches the observed dust lanes. The best-fit models suggest that the M/L of NGC 1291 agrees with that predicted by stellar population synthesis models in the near-infrared (≈ 0.6 M⊙/L⊙), which leads to a borderline maximum disc for this galaxy. The bar rotates fast, with corotation radius ⩽ 1.4 times the bar length. Additionally, we find that the height function has a significant effect on the results, and can bias them towards lower or higher M/L.
In this study, age of onset (AoO) was investigated in five- and six-year-old bilingual Frisian–Dutch children. AoO to Dutch ranged between zero and four and had a positive effect on Dutch receptive vocabulary size, but hardly influenced the children's accurate use of Dutch inflection. The influence of AoO on vocabulary was more prominent than the influence of exposure. Regarding inflection, the reverse was found. Accuracy at using Frisian inflection emerged as a significant predictor; this transfer effect was modulated by lexical overlap between the two languages. This study shows that ‘the sooner the better’ does not necessarily hold for language development. In fact, for the correct use of inflection, it does not matter whether children start at age zero or four. For rapidly learning words in a new language it may be helpful to first build a substantial vocabulary in the first language before learning a new language.