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Chapter 1 - The normal lung: histology, embryology, development, aging and function

Published online by Cambridge University Press:  05 June 2014

By
Neil Sahasrabudhe ,
John R. Gosney  and
Philip Hasleton
Edited by
Philip Hasleton  and
Douglas B. Flieder
Philip Hasleton
Affiliation:
University of Manchester
Douglas B. Flieder
Affiliation:
Fox Chase Cancer Center, Philadelphia
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Summary

Introduction

Knowledge of normal lung anatomy and function is important for the interpretation of lung biopsies and resections. An understanding of different cell structures and functions allows for a greater appreciation of disease states. In addition basic pulmonary embryology explains congenital pulmonary defects. At the other extreme of life, knowledge of how the lung ages is important, not only for consideration of other diseases, such as hiatus hernias with co-existent aspiration, but also because of the world's increasing elderly population.

Development

The key events of pulmonary embryogenesis and postnatal development are discussed in this chapter. For a more detailed account, the reader is referred to two monographs and several review articles.

The events of human lung growth are divided into five continuous stages, based on anatomic and histological characteristics. These are the embryonic, pseudoglandular, canalicular, saccular and alveolar stages (Table 1) (Figures 1 and 2). Airway and vascular development are closely related. The conducting airways are formed in the embryonic and pseudoglandular stages, while gas exchange units characterized by vascularization and reduction of mesenchyme are formed in the canalicular, saccular and alveolar stages.

Type
Chapter
Information
Spencer's Pathology of the Lung , pp. 1 - 40
Publisher: Cambridge University Press
Print publication year: 2000

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