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4 - Sperm RNA and Its Use as a Clinical Marker

Published online by Cambridge University Press:  25 May 2017

Christopher J. De Jonge
Affiliation:
University of Minnesota
Christopher L. R. Barratt
Affiliation:
University of Dundee
Ryuzo Yanagimachi
Affiliation:
University of Hawaii, Manoa
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Summary

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Chapter
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The Sperm Cell
Production, Maturation, Fertilization, Regeneration
, pp. 59 - 72
Publisher: Cambridge University Press
Print publication year: 2017

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References

Inhorn, MC, Patrizio, P. Infertility around the globe: New thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update 2015; 21: 411–26.CrossRefGoogle ScholarPubMed
Petraglia, F, Serour, GI, Chapron, C. The changing prevalence of infertility. Int J Gynaecol Obstet 2013; 123 Suppl 2: S48.CrossRefGoogle ScholarPubMed
Roy, A, Lin, YN, Matzuk, MM. Genetics of idiopathic male infertility: The power of a cross-species approach. In: Carrell, D (Ed.), The Genetics of Male Infertility. Humana, 2007.CrossRefGoogle Scholar
WHO. WHO laboratory manual for examination and processing of human semen (fifth ed.). World Health Organitzation, 2010.Google Scholar
Lefievre, L et al. Counting sperm does not add up any more: Time for a new equation? Reproduction 2007; 133: 675–84.CrossRefGoogle Scholar
Lewis, SE. Is sperm evaluation useful in predicting human fertility? Reproduction 2007; 134: 3140.CrossRefGoogle ScholarPubMed
Anton, E, Krawet, SA. Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity. Syst Biol Reprod Med 2012; 58: 4150.CrossRefGoogle ScholarPubMed
Johnson, GD et al. The sperm nucleus: Chromatin, RNA, and the nuclear matrix. Reproduction 2011; 141: 2136.CrossRefGoogle ScholarPubMed
Martins, RP, Krawetz, SA. Nuclear organization of the protamine locus. Soc Reprod Fertil Suppl 2007; 64: 112.Google ScholarPubMed
Oliva, R. Protamines and male infertility. Hum Reprod Update, 2006; 12: 417–35.CrossRefGoogle ScholarPubMed
Ostermeier, GC et al. Reproductive biology: Delivering spermatozoan RNA to the oocyte. Nature 2004; 429: 154.CrossRefGoogle ScholarPubMed
Hamatani, T. Human spermatozoal RNAs. Fertil Steril 2012; 97: 275–81.CrossRefGoogle ScholarPubMed
Boerke, A, Dieleman, SJ, Gadell, BM. A possible role for sperm RNA in early embryo development. Theriogenology 2007; 68 Suppl 1: S147–55.CrossRefGoogle ScholarPubMed
Jodar, M et al. The presence, role and clinical use of spermatozoal RNAs. Hum Reprod Update 2013; 19: 604–24.CrossRefGoogle ScholarPubMed
Sendler, E et al. Stability, delivery and functions of human sperm RNAs at fertilization. Nucl Acids Res 2013; 41: 4,104–17.CrossRefGoogle ScholarPubMed
Goodrich, RJ, Anton, E, Krawetz, SA. Isolating mRNA and small noncoding RNAs from human sperm. Methods Mol Biol 2013; 927: 385–96.CrossRefGoogle ScholarPubMed
Sendler, E et al. Stability, delivery and functions of human sperm RNAs at fertilization. Nucl Acids Res 2013; 41: 4104–17.CrossRefGoogle ScholarPubMed
Johnson, GD et al. Cleavage of rRNA ensures translational cessation in sperm at fertilization. Mol Hum Reprod 2011; 17: 721–6.CrossRefGoogle ScholarPubMed
Jodar, M et al. Absence of sperm RNA elements correlates with idiopathic male infertility. Sci Transl Med 2015; 7: 295re6.CrossRefGoogle ScholarPubMed
He, Z et al. Small RNA molecules in the regulation of spermatogenesis. Reproduction 2009; 137: 901–11.CrossRefGoogle ScholarPubMed
Matzuk, MM, Lamb, DJ. The biology of infertility: Research advances and clinical challenges. Nat Med 2008; 14: 1,197213.CrossRefGoogle ScholarPubMed
Ostermeier, GC et al. A suite of novel human spermatozoal RNAs. J Androl 2005; 26: 70–4.CrossRefGoogle ScholarPubMed
Griffiths-Jones, S. The microRNA Registry. Nucl Acids Res 2004 32: D109–11.CrossRefGoogle ScholarPubMed
Friedman, RC et al. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19: 92105.CrossRefGoogle ScholarPubMed
Zamore, PD, Haley, B. Ribo-gnome: The big world of small RNAs. Science 2005; 309: 1,519–24.CrossRefGoogle ScholarPubMed
McIver, SC et al. miRNA and mammalian male germ cells. Hum Reprod Update 2012; 1: 4459.CrossRefGoogle Scholar
Khazaie, Y, Nasr Esfahani, MH. MicroRNA and male infertility: A potential for diagnosis. Int J Fertil Steril 2014; 8: 113–8.Google ScholarPubMed
Ha, M, Kim, VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 2014; 15: 509–24.CrossRefGoogle ScholarPubMed
Saini, HK Griffiths-Jones, S, Enright, AJ. Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci USA 2007; 104: 17,719–24.CrossRefGoogle ScholarPubMed
Fang, Z et al. The sequence structures of human microRNA molecules and their implications. PLoS One 2013; 8: e54215.CrossRefGoogle ScholarPubMed
Goh, WS et al. piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis. Genes Dev 2015; 29: 1,032–44.CrossRefGoogle ScholarPubMed
Sai Lakshmi, S Agrawal, S. piRNABank: A Web resource on classified and clustered Piwi-interacting RNAs. Nucl Acids Res 2008; 36: D173–7.CrossRefGoogle ScholarPubMed
Siomi, MC et al. PIWI-interacting small RNAs: The vanguard of genome defence. Nat Rev Mol Cell Biol 2011; 12: 246–58.CrossRefGoogle ScholarPubMed
Lin, H. piRNAs in the germ line. Science 2007; 316: 397.CrossRefGoogle ScholarPubMed
Reuter, M et al. Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature 2011; 480: 264–7.CrossRefGoogle ScholarPubMed
Peng, JC, Lin, H. Beyond transposons: The epigenetic and somatic functions of the Piwi-piRNA mechanism. Curr Opin Cell Biol 2013; 25: 190–4.CrossRefGoogle ScholarPubMed
Zhang, P et al. MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes. Cell Res 2015; 25: 193207.CrossRefGoogle ScholarPubMed
Zhao, S et al. piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev Cell 2013; 24: 1325.CrossRefGoogle ScholarPubMed
Sytnikova, Y, Lau, NC. Does the APC/C mark MIWI and piRNAs for a final farewell? Dev Cell 2013; 24: 119–20.CrossRefGoogle ScholarPubMed
Aravin, A et al. A novel class of small RNAs bind to MILI protein in mouse testes. Nature 2006; 442: 203–7.CrossRefGoogle ScholarPubMed
Deng, W, Lin, H. miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell 2002; 2: 819–30.CrossRefGoogle ScholarPubMed
Girard, A et al. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature 2006; 442: 199202.CrossRefGoogle ScholarPubMed
Krawetz, SA et al. A survey of small RNAs in human sperm. Hum Reprod 2011 26: 3,401–12.CrossRefGoogle ScholarPubMed
Pantano, L et al. The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes. RNA 2015; 21: 1085–95.CrossRefGoogle ScholarPubMed
Gou, LT et al. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res 2014; 24: 680700.CrossRefGoogle ScholarPubMed
Gou, LT et al. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis. Cell Res 2015; 25: 266.CrossRefGoogle ScholarPubMed
Bouhallier, F et al. Role of miR-34c microRNA in the late steps of spermatogenesis. RNA 2010; 16: 720–31.CrossRefGoogle ScholarPubMed
Liu, WM et al. Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci USA 2012; 109: 490–4.Google Scholar
Yuan, S et al. mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice. Biol Open 2015; 4: 212–23.CrossRefGoogle Scholar
Lalancette, C et al. Identification of human sperm transcripts as candidate markers of male fertility. J Mol Med 2009; 87: 735–48.CrossRefGoogle ScholarPubMed
Esteves, SC, Miyaoka, R, Agarwal, A. An update on the clinical assessment of the infertile male [corrected]. Clinics (São Paulo) 2011; 66: 691700.CrossRefGoogle ScholarPubMed
Bansal, SK et al. Differential genes expression between fertile and infertile spermatozoa revealed by transcriptome analysis. PLoS One 2015; 10: e0127007.CrossRefGoogle ScholarPubMed
Jodar, M et al. Differential RNAs in the sperm cells of asthenozoospermic patients. Hum Reprod 2012; 27: 1,431–8.CrossRefGoogle ScholarPubMed
Montjean, D et al. Sperm transcriptome profiling in oligozoospermia. J Assist Reprod Genet, 2012. 29(1): 310.CrossRefGoogle ScholarPubMed
Platts, AE et al. Disease progression and solid tumor survival: A transcriptome decoherence model. Mol Cell Probes 2010; 24: 5360.CrossRefGoogle ScholarPubMed
McLachlan, RI. Approach to the patient with oligozoospermia. J Clin Endocrinol Metab 2013; 98: 873–80.CrossRefGoogle Scholar
Guo, X et al. Differential expression of VASA gene in ejaculated spermatozoa from normozoospermic men and patients with oligozoospermia. Asian J Androl 2007; 9: 339–44.CrossRefGoogle ScholarPubMed
Yatsenko, AN et al. UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men. Mol Hum Reprod 2013; 19: 388394.CrossRefGoogle ScholarPubMed
Ferlin, A et al. Heat shock protein and heat shock factor expression in sperm: Relation to oligozoospermia and varicocele. J Urol 2010; 183: 1,248–52.CrossRefGoogle ScholarPubMed
Geijsen, N et al. Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature 2004; 427: 148–54.CrossRefGoogle ScholarPubMed
Baarends, WM, Grootegoed, JA. Chromatin dynamics in the male meiotic prophase. Cytogenet Genome Res 2003; 103: 225–34.Google ScholarPubMed
de Jong, AM et al. Effect of alcohol intake and cigarette smoking on sperm parameters and pregnancy. Andrologia 2014; 46: 112–7.CrossRefGoogle ScholarPubMed
Eslamian, G et al. Intake of food groups and idiopathic asthenozoospermia: A case-control study. Hum Reprod 2012; 27: 3,328–36.CrossRefGoogle ScholarPubMed
Marchini, M et al. Etiology of severe asthenozoospermia and fertility prognosis. A screening of 5216 semen analyses. Andrologia 1991; 23: 115–20.Google ScholarPubMed
Kempisty, B et al. Evaluation of protamines 1 and 2 transcript contents in spermatozoa from asthenozoospermic men. Folia Histochem Cytobiol 2007; 45: S109–13.Google ScholarPubMed
Jedrzejczak, P et al. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. Arch Androl 2007; 53: 199205.CrossRefGoogle ScholarPubMed
Miyagawa, Y et al. Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. J Androl 2005; 26: 779–86.CrossRefGoogle ScholarPubMed
Liu, B et al. Analysis and difference of voltage-dependent anion channel mRNA in ejaculated spermatozoa from normozoospermic fertile donors and infertile patients with idiopathic asthenozoospermia. J Assist Reprod Genet 2010; 27: 719–24.CrossRefGoogle ScholarPubMed
Shen, S et al. Low-expressed testis-specific calcium-binding protein CBP86-IV (CABYR) is observed in idiopathic asthenozoospermia. World J Urol 2015; 33: p633–8.CrossRefGoogle ScholarPubMed
Chen, K et al. Low NRF2 mRNA expression in spermatozoa from men with low sperm motility. Tohoku J Exp Med 2012; 228: 259–66.CrossRefGoogle ScholarPubMed
Imamovic Kumalic, S, Pinter, B. Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic oligoasthenoteratozoospermia. Biomed Res Int 2014; 2014: 426951.CrossRefGoogle ScholarPubMed
Kruger, TF et al. A quick, reliable staining technique for human sperm morphology. Arch Androl 1987; 18: 275–7.CrossRefGoogle ScholarPubMed
Gaur, DS, Talekar, MS, Pathak, VP. Alcohol intake and cigarette smoking: Impact of two major lifestyle factors on male fertility. Indian J Pathol Microbiol 2010; 53: 3540.CrossRefGoogle ScholarPubMed
Ragni, G et al. Evaluation of semen and pituitary gonadotropin function in men with untreated Hodgkin's disease. Fertil Steril 1985; 43: 927–30.CrossRefGoogle ScholarPubMed
Volta, U, Villanacci, V. Celiac disease: Diagnostic criteria in progress. Cell Mol Immunol 2011; 8: 96102.CrossRefGoogle ScholarPubMed
Platts, AE et al. Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs. Hum Mol Genet 2007; 16: 763–73.CrossRefGoogle ScholarPubMed
Kong, M, Diaz, ES, Morales, P. Participation of the human sperm proteasome in the capacitation process and its regulation by protein kinase A and tyrosine kinase. Biol Reprod 2009; 80: 1,026–35.CrossRefGoogle ScholarPubMed
Cedenho, AP et al. Oligozoospermia and heat-shock protein expression in ejaculated spermatozoa. Hum Reprod 2006; 21: 1,791–4.CrossRefGoogle ScholarPubMed
Li, C et al. Absence of nerve growth factor and comparison of tyrosine kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men. Clin Chim Acta 2010; 411: 1,482–6.CrossRefGoogle ScholarPubMed
Zheng, L et al. Expression of brain-derived neurotrophic factor in mature spermatozoa from fertile and infertile men. Clin Chim Acta 2011; 412: p44–7.CrossRefGoogle ScholarPubMed
Abu-Halima, M et al. Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments. Fertil Steril 2013; 99: 1,249–55 e16.CrossRefGoogle ScholarPubMed
Abu-Halima, M et al. A panel of five microRNAs as potential biomarkers for the diagnosis and assessment of male infertility. Fertil Steril 2014; 102: 989–97 e1.CrossRefGoogle ScholarPubMed
Salas-Huetos, A et al. New insights into the expression profile and function of micro-ribonucleic acid in human spermatozoa. Fertil Steril 2014; 102: 213–22 e4.CrossRefGoogle ScholarPubMed
Salas-Huetos, A et al. Spermatozoa from patients with seminal alterations exhibit a differential miRNA profile. Fertil Steril 2015; doi: 10.1016/j.fertnstert.2015.06.015.CrossRefGoogle Scholar
Duran, HE et al. Intrauterine insemination: A systematic review on determinants of success. Hum Reprod Update 2002; 8: 373–84.CrossRefGoogle ScholarPubMed
Practice Committees of the American Society for Reproductive Medicine and Society for Assisted Reproductive Technology. Intracytoplasmic sperm injection (ICSI) for non-male factor infertility: A committee opinion. Fertil Steril 2012; 98: 1,395–9.Google Scholar
Pashayan, N, Lyratzopoulos, G, Mathur, R. Cost-effectiveness of primary offer of IVF vs. primary offer of IUI followed by IVF (for IUI failures) in couples with unexplained or mild male factor subfertility. BMC Health Serv Res 2006; 6: 80.CrossRefGoogle ScholarPubMed
Piskol, R, Ramaswami, G, Li, JB. Reliable identification of genomic variants from RNA-seq data. Am J Hum Genet 2013; 93: 641–51.CrossRefGoogle ScholarPubMed
Selvaraju, S, Jodar, M, Krawetz, S. The influence of environmental contaminants and lifestyle on testicular damage and male fertility. Humana Press, 2014: 119.Google Scholar
Carone, BR et al. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 2010; 143: 1,084–96.CrossRefGoogle ScholarPubMed
Ng, S et al. Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature 2010; 467: 963U103.CrossRefGoogle ScholarPubMed
Lombo, M et al. Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure. Environ Pollut 2015; 206: 667–78.CrossRefGoogle ScholarPubMed
Dias, BG, Ressler, KJ. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neurosci 2014; 17: 8996.CrossRefGoogle ScholarPubMed
Cossetti, C et al. Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: Possible transport by exosomes. PLoS One 2014; 9: e101629.CrossRefGoogle ScholarPubMed
Gapp, K et al. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nat Neurosci 2014; 17: 667–9.CrossRefGoogle ScholarPubMed
Rando, OJ. Daddy issues: Paternal effects on phenotype. Cell 2012; 151: 702–8.CrossRefGoogle ScholarPubMed
Fullston, T et al. Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB J 2013; 27: 4,226–43.CrossRefGoogle Scholar
McPherson, NO et al. Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring. Am J Physiol Endocrinol Metab 2015; 308: E805–21.CrossRefGoogle ScholarPubMed
Vojtech, L et al. Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions. Nucleic Acids Res 2014; 42: 7,290304.CrossRefGoogle ScholarPubMed
Bromfield, JJ. Seminal fluid and reproduction: Much more than previously thought. J Assist Reprod Genet 2014; 31: 627–36.CrossRefGoogle ScholarPubMed
Jodar, M, Sendler, E, Krawetz, SA. The protein and transcript profiles of human semen. Cell Tissue Res 2015; 363( ): 8596.CrossRefGoogle ScholarPubMed
Pansa, A et al. ESX1 mRNA expression in seminal fluid is an indicator of residual spermatogenesis in non-obstructive azoospermic men. Hum Reprod 2014; 29: 2,620–7.CrossRefGoogle ScholarPubMed
Practice Committee of the American Society for Reproductive Medicine. Effectiveness and treatment for unexplained infertility. Fertil Steril 2006; 86: S111–4.Google Scholar

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