Children whose mothers received prenatal progesterone have been shown to be advanced in development at one year and to have greater academic achievement at 9–10 years. This study compares the educational attainments at 17–20 years of 34 progesterone children with 37 normal and 12 toxaemic controls. More progesterone children continued schooling after 16 years compared with controls; a higher proportion left school with ‘O’ level and ‘A’ level passes, the average number of passes per child was greater at both levels and more obtained a university place. The best academic results were in those whose mothers had received over 5 grams of prenatal progesterone, and for whom administration commenced before the sixteenth week and treatment lasted longer than eight weeks.

Prospective developmental data on 33 children of consensus diagnosed schizophrenic parents were compared to control samples of children of other psychiatric patients and children of normal parents. Contrary to several reports, the children of schizophrenics, observed from birth to age seven, were remarkably normal on a host of pregnancy and delivery variables, neurological examinations, physical growth measures, and psychological tests. However, a combination of three indicators characterized five of the 116 children, and all five were offspring of schizophrenics (17 per cent of the high risk sample), thus matching the expected lifetime risk for schizophrenia previously observed in such samples. Case histories show that all five children have enduring patterns of maladjustment and exhibit behaviours often reported in the premorbid histories of schizophrenics. Most have family histories heavily loaded with schizophrenia. In terms of a diathesis-stress model, these five children appear especially vulnerable to future schizophrenia in the absence of rational methods of prevention.

The topic of psychiatric classification has generated more interest and controversy in the last decade than for a long time. Several trends have coalesced to foster its resurgence as a subject of debate. First, a sociological perspective on psychopathology has gained widespread attention (Becker, 1963; Matza, 1969; Scheff, 1966). The exponents of this perspective have focused on the effects of ‘labelling.’ Their writings have stimulated mental health professionals to examine the consequences of applying classificatory systems in psychiatry. Second, the rapid development of behaviour modification has been a source of numerous polemical attacks on the ‘medical model’ and on the classification system derived from the notion that psychological disturbances constitute a finite number of varieties of mental illness (e.g., Ullmann and Krasner, 1975). Third, criticisms have been voiced of the unsatisfactory reliability of the standard/accepted national and international psychiatric classification schemes (e.g., Scharfetter, 1971; Spitzer and Wilson, 1974). Such criticisms have sparked the development of new classificatory systems notable for the specificity and explicitness of rules of diagnostic assignment (Feighner et al, 1972; Spitzer, Endicott, and Robins, 1974).

A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.

The season of birth of the siblings of psychiatric patients was studied to test the hypothesis that an unusual seasonal pattern of maternal conception is the cause of the excess of births in the early months of the year which has been found in national studies of psychotic patients. Information on the month of birth of the siblings was obtained from interviews with psychiatric in-patients born in Britain. The quarterly distribution of births of 670 mentally well siblings of psychotic patients (schizophrenia and manic-depression) was significantly different from that of 1,513 siblings of other psychiatric patients and also from that of all births in England and Wales. The results lend qualified support to the hypothesis, but they were not clear-cut and there was some evidence that the information on birth dates was biased.

The 24-hour oral temperatures of 51 chronic schizophrenic patients, 19 non-schizophrenic chronic psychiatric patients and 14 non-patients have been measured and compared. The chronic schizophrenics have an earlier peak temperature and differ significantly from the other groups. Compared with the non-schizophrenic patients their hourly mean temperatures reach significantly higher levels in the morning. Compared with the non-patients their mean temperatures fall to significantly lower levels in the evening after 5.00 pm.

The effectiveness of a community mental health programme in a developing country (Fiji) is examined. The programme was remarkable in that very little expertise was available in the community for it to be carried through. The results indicate that one category of hospital in-patient will subsequently derive significant benefit, namely the patient diagnosed as having schizophrenia who has been in a mental hospital more than once.

Evidence from this study confirmed observations made by others that benign acute psychotic episodes are not infrequent in this sort of setting.

Two series of patients with epilepsy and with febrile convulsions were analysed on Slater's computational model for evidence on the mode of inheritance. The study demonstrated that in both series a polygenic inheritance may be more likely than an autosomal dominant or recessive inheritance.

Associative intrusions in the thought of short-term and long-term schizophrenic, non-schizophrenic, and non-psychiatric in-patients were measured using Rattan and Chapman's multiple-choice vocabulary test. This test consists of two subtests, one with associative distractors and the other without distractors, which are matched on discriminating power and thus permit the assessment of differential specific performance deficit uncontaminated by the generalized deficit characteristic of many patient groups.

Results indicated that some susceptibility to associative intrusions characterizes all groups of long-term patients regardless of diagnosis. Short-term patients (with the possible exception of schizophrenic) did not show such heightened susceptibility.

Lengthy illness and/or stay in hospital are apparently implicated in at least this form of thought disorder, which has been often considered to be a uniquely schizophrenic phenomenon.

The Chair of the University Nervenklinik in Homburg/Saar was held by Klaus Conrad from 1949-58 and by H.-H, Meyer, a former pupil and colleague of Kurt Schneider, from 1962-72. As the catchment area and admission policy of the clinic remained substantially unchanged throughout, comparison of the relative proportions of all admissions allocated to different diagnostic categories in 1949-58 and 1962-72 can be used to elucidate the similarities and differences between Conrad's and Schneider's diagnostic criteria. The results of this comparison indicate that Schneider's concept of schizophrenia was broader than Conrad's, and his concept of manic-depressive depx-ession more restricted. More detailed comparisons are complicated by differences in nomenclature and in the varieties of functional mental illness recognized in the two periods. However, it seems that Conrad's concept of mania was wider only when the atypical schizophrenia-like psychoses diagnosed during the Conrad era were added to the Conrad-oriented cases of mania; when this was not done, the Schneiderian concept of mania was broader.

Psychiatric descriptions of bodily symptoms have usually been derived from narrowly restricted clinical experience. It is argued that it is more useful to review evidence from all medical settings and occurrence, nature, disability and presentation are here discussed. Syndromes of hypochondriacal reactions appear to be extreme and uncommon manifestations of a universal potential.

Studies on the relationship between season of birth and mental disorder have been substantially confined to northern hemisphere regions. Such studies have generally found an excess of winter births of schizophrenics, and variably an excess of winter births of manic-depressive and mentally retarded patients. In the present study information on sex, diagnosis and date of birth was obtained on all 20,358 patients first admitted to psychiatric facilities in New South Wales between July 1970 and June 1974 and born in New South Wales. The collective 1962–71 monthly live-births for New South Wales were used as a control. A significant winter excess was found for the female schizophrenic group, while a significant spring excess was found for neurotic patients, most marked in those with anxiety neurosis. It is hypothesized that the relationship between schizophrenia and winter birth is consequent upon a greater sensitivity of schizophrenics to those physiological factors which determine conception in the general population.

A number of anthropometric measurements were made on Southern Chinese women. These were 317 schizophrenics, 44 with affective disorder, 47 neurotics and normal controls. All groups and sub-groups compared were matched for mean age and socio-economic status. It was found that the intercorrelations between body build, personality and type of mental illness were on the whole similar to those reported for Caucasians.

A brief survey, using a standardized questionnaire, has been made of hand preference patterns in a series of patients admitted to hospital with functional psychiatric disorders. A small but significant shift towards left hand preference has been observed, more marked in the young patients and virtually confined to the males. Psychotic patients show such a shift more clearly than neurotic or personality disordered patients. Simple genetic factors do not appear to be responsible for these sinistral tendencies. The findings are discussed in relation to possible acquired abnormalities of functional brain organization.

An assessment was made of 100 case records written by junior medical staff working in a psychiatric teaching hospital. Thirty-nine items were rated, and considerable gaps were found in the records. The Mental State was more poorly recorded than the History; the Formulation and Summary were more satisfactory. Possible reasons for the findings are discussed, including methodological difficulties, administrative considerations, and attitudes of junior staff. The implications for the training and assessment of junior psychiatrists are explored.

This paper extends the recent work of Hall (1974) by presenting the minimal sample sizes and the specific linear agreement weights required for assessing the reliability of rating scales commonly used in neuropsychiatric and other clinico-medicai settings. The weights are shown to vary as a function of (a) whether or not the rating scale contains a point of ‘absence’, and (b) the number of ordinal points on the scale.

The Ryle Marital Patterns Test measures the affection and domination aspects of marriage. Its original administration illustrated a partial association between poor marital adjustment (as measured by low affection scores and non-egalitarian domination scores) and neuroticism (as measured by CMI score). The present paper confirms these associations using a group of suburban women defined as neurotic by their GP. Related studies suggest similar patterns.

A sample of ‘automatic speech’ (counting from 1 to 10) was tape-recorded and the times taken up by phonation and pauses measured. In four healthy volunteers, both phonation times and pause times remained constant over a period of two months. In four moderately depressed patients, with no history of manic illness and with no obvious clinical signs of motor retardation, the pause times were significantly elongated while the patients were depressed compared to pause times measured after recovery. The phonation times were constant throughout the period of observation (4–6 months). Other tests for motor retardation (tapping time; Nurses' rating scale; Hamilton Retardation Scores) did not give consistent results. It is concluded that the simple test described here may reveal a degree of motor retardation in cases where other tests fail to do so.

A comparison is made between the General Health Questionnaire (GHQ) and the Symptom Checklist (SCL) as psychiatric screening tests in community-based research projects. Both are shown to correlate equally well with independent clinical assessment, and the differences between them mainly reside in the form of their response scales. The GHQ works best as a screening test, since it has fewer false positives associated with its use, but it may miss those with long-standing disorders. The SCL tends not to miss long-standing disorders and furnishes diagnostic sub-scales if these are required. Both tests function better with men than with women and with whites than with blacks, but neither is affected by social class or age of the respondent. The study revealed high correlations between the symptoms of anxiety and depression, and indicated some possible differences between the symptom clusters seen in whites and in blacks.

Each of thirty-six female agoraphobic out-patients were treated by one of three methods: 8 sessions of imaginal flooding followed by 8 sessions of practice in the real situation; 16 sessions of combined flooding and practice; or 16 sessions of practice alone. Three therapists treated equal numbers of patients in each group, and there was some evidence that patients' response varied according to the therapist seen, irrespective of treatment group. There were no significant differences between treatment groups after 8 sessions, 16 sessions or on six-month follow-up. It is concluded that there are no long-term differences between the effects of treatments involving exposure to either imaginai or real phobic situations or to a combination of both, provided that patients are encouraged to practise between sessions.