Hostname: page-component-77c89778f8-7drxs Total loading time: 0 Render date: 2024-07-17T21:48:17.385Z Has data issue: false hasContentIssue false

Polygenic Inheritance of Epilepsy and Febrile Convulsions: Analysis based on a Computational Model

Published online by Cambridge University Press:  29 January 2018

Takayuki Tsuboi*
Affiliation:
Department of Genetics, Tokyo Metropolitan Institute of Neurosciences, Fuchu, Tokyo, Japan

Summary

Two series of patients with epilepsy and with febrile convulsions were analysed on Slater's computational model for evidence on the mode of inheritance. The study demonstrated that in both series a polygenic inheritance may be more likely than an autosomal dominant or recessive inheritance.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1976 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alström, C. H. (1950) A study of epilepsy in its clinical, social and genetic aspects. Acta psychiat. neurol. Scand. Suppl 63.Google Scholar
Cordier, J. (1958) Quelques observations d'épilepsie ‘génétique’. Acta neurol. psychiat. Belg., 58, 1025.Google Scholar
Eisner, V., Pauli, L. L. & Livingston, S. (1959) Hereditary aspects of epilepsy. Bull. Johns Hopk. Hosp., 105, 245–71.Google ScholarPubMed
Gastaut, H. (1969) On genetic transmission of epilepsies. Epilepsia, 10, 36.Google Scholar
Hoff, H. (1950) Neue Fragestellung zum Epilepsie-problem. Wien. klin. Wschr., 62, 93113.Google Scholar
Kimball, O. P. (1954) On the inheritance of epilepsy. Wisc. med. J., 53, 271–6.Google ScholarPubMed
Macklin, M. T. (1953) Is idiopathic convulsive disorder partially sex-linked? Amer. J. hum. Genet., 4, 356–62.Google Scholar
Metrakos, J. & Metrakos, J. D. (1961) Genetics of convulsive disorders. II. Genetics and electroencephalographic studies in centrencephalic epilepsy. Neurolog. (Minneap.), 11, 474–83.Google Scholar
Slater, E. (1966) Expectation of abnormality on paternal and maternal sides: a computational model. J. med. Genet., 3, 159–61.Google Scholar
Slater, E. & Tsuano, M.-T. (1968) Abnormality on paternal and maternal sides: observations in schizophrenia and manic-depression. J. med. Genet., 5, 197–9.Google Scholar
Strauss, H., Rahm, W. E. & Bassera, S. E. (1939) Electroencephalographic studies in relatives of epilepsies. Proc. Soc. exper. biol. Med., 42, 207–12.CrossRefGoogle Scholar
Tsuboi, T. & Christian, W. (1973) On the genetics of the primary generalized epilepsy with sporadic myoclonias of impulsive petit mal type: a clinical and electroencephalographic study of 399 probands. Humangenetik, 19, 155–82.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.