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  • Handbook of Industrial Crystallization
  • 3rd edition
  • Online publication date: June 2019
  • pp v-vii
  • Publisher: Cambridge University Press


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  1. List of Contributors

  2. Preface to the First Edition

  3. Preface to the Second Edition

  4. Preface to the Third Edition

  5. 1Solutions and Solution Properties

    Jennifer Moffitt Schall and Allan S. Myerson

    1. 1.1Introduction and Motivation

    2. 1.2Units

    3. 1.3Solubility of Inorganics

    4. 1.4Solubility of Organics

    5. 1.5Supersaturation and Metastability

    6. 1.6Solution Properties

    7. 1.7Thermal Properties

    8. References

  6. 2Crystals and Crystal Growth

    Alfred Y. Lee, Deniz Erdemir, and Allan S. Myerson

    1. 2.1Introduction

    2. 2.2Basic Concepts of the Solid State

    3. 2.3Crystal Nucleation

    4. 2.4Crystal Growth

    5. 2.5Crystal Habit

    6. 2.6Crystal Polymorphism

    7. 2.7Multicomponent Crystals

    8. 2.8Crystal Size

    9. 2.9Concluding Remarks

    10. References

  7. 3Crystal Nucleation

    Deniz Erdemir, Alfred Y. Lee, and Allan S. Myerson

    1. 3.1Introduction

    2. 3.2Homogeneous Nucleation

    3. 3.3Heterogeneous Nucleation

    4. 3.4Secondary Nucleation

    5. 3.5Nucleation Kinetics

    6. 3.6Control of Nucleation

    7. 3.7Nucleation in Polymorphic Systems

    8. 3.8Methods to Induce Nucleation

    9. References

  8. 4The Influence of Impurities and Additives on Crystallization

    Lucrèce Hèlène Nicoud and Allan S. Myerson

    1. 4.1Introduction

    2. 4.2Retention of Foreign Species in Crystals

    3. 4.3Impact of Foreign Species on Growth Rate

    4. 4.4Impact of Foreign Species on Crystal Properties

    5. 4.5Conclusion

    6. References

  9. 5Molecular Modeling Applications in Crystallization

    Keith Chadwick, Jie Chen, Erik E. Santiso, and Bernhardt L. Trout

    1. 5.1Introduction

    2. 5.2Crystal Structure Visualization and Analysis Software

    3. 5.3Morphology Prediction

    4. 5.4Crystal Structure Determination from X-Ray Powder Diffraction Data

    5. 5.5Modeling Nucleation and Phase Transitions

    6. 5.6Polymorph Searching and Prediction

    7. 5.7Solubility Prediction

    8. 5.8Chapter Summary and Outlook

    9. References

  10. 6Crystallization Process Analysis by Population Balance Modeling

    Åke C. Rasmuson

    1. 6.1Introduction

    2. 6.2Particle Size and Size Distribution

    3. 6.3Crystallization Kinetics

    4. 6.4Population Balance Modeling

    5. 6.5The Idealized MSMPR Concept

    6. 6.6Continuous Crystallization and Deviations from the MSMPR Model

    7. 6.7Batch Crystallization

    8. 6.8Population Balance Modeling of Non-Well-Mixed Processes

    9. 6.9Determination of Crystallization Kinetics for Process Modeling

    10. 6.10Conclusions

    11. References

  11. 7Selection and Design of Industrial Crystallizers

    Herman J. M. Kramer and Richard Lakerveld

    1. 7.1Introduction

    2. 7.2Performance Criteria

    3. 7.3Crystallization Methods

    4. 7.4Equipment Design

    5. 7.5Instrumentation and Actuation

    6. 7.6Case Study: Optimization of a Base-Case Design

    7. References

  12. 8Precipitation Processes

    Piotr H. Karpiński and Jerzy Bałdyga

    1. 8.1Introduction

    2. 8.2Physical and Thermodynamic Properties

    3. 8.3Nucleation Kinetics

    4. 8.4Crystal Growth Kinetics in Precipitation

    5. 8.5Other Processes and Models in Precipitation

    6. 8.6Experimental Techniques

    7. 8.7Modeling and Control of Crystal Size and Crystal Size Distribution

    8. 8.8Scale-Up Rules for Precipitation

    9. 8.9Precipitation in Practice

    10. 8.10Summary

    11. References

  13. 9Melt Crystallization

    Joachim Ulrich and Torsten Stelzer

    1. 9.1Definitions

    2. 9.2Benefits of Melt Crystallization

    3. 9.3Phase Diagrams

    4. 9.4Crystallization Kinetics

    5. 9.5Processes of Melt Crystallization

    6. 9.6Post-Crystallization Treatments

    7. 9.7Concepts of Commercial Plants

    8. 9.8Eutectic Freeze Crystallization

    9. 9.9Summary and View to the Future

    10. References

  14. 10Crystallizer MixingUnderstanding and Modeling Crystallizer Mixing and Suspension Flow

    Daniel A. Green

    1. 10.1Introduction

    2. 10.2Crystallizer Flows

    3. 10.3Crystallizers

    4. 10.4Scale-Up

    5. 10.5Modeling

    6. 10.6Summary

    7. References

  15. 11Monitoring and Advanced Control of Crystallization Processes

    Zoltan K. Nagy, Mitsuko Fujiwara, and Richard D. Braatz

    1. 11.1Introduction

    2. 11.2Crystallization Process Monitoring

    3. 11.3Model-Based Optimization and Control of Crystallization Processes

    4. 11.4Model-Free (Direct Design) Approaches

    5. 11.5Summary

    6. References

  16. 12Batch Crystallization

    Piotr H. Karpiński and Jerzy Bałdyga

    1. 12.1Introduction

    2. 12.2Batch Crystallizers

    3. 12.3Batch Crystallization Analysis

    4. 12.4Factors Affecting Batch Crystallization

    5. 12.5Batch Crystallization Operations

    6. 12.6Scale-Up of Batch Crystallization

    7. 12.7Summary

    8. References

  17. 13Crystallization in the Pharmaceutical Industry

    Simon N. Black

    1. 13.1Introduction

    2. 13.3Increasing Complexity

    3. 13.4Crystallization Kinetics

    4. 13.5Particle Engineering

    5. 13.6After the Crystallizer

    6. 13.7Intermediates

    7. 13.8Other Crystallizations

    8. 13.9Summary

    9. References

  18. 14Crystallization of Proteins

    Peter G. Vekilov

    1. 14.1Introduction

    2. 14.2Protein and Protein Crystals

    3. 14.3The Thermodynamics of Protein Crystallization

    4. 14.4Methods of Protein Crystallization

    5. 14.5The Role of Nonprotein Solution Components and the Intermolecular Interactions in Solution

    6. 14.6Crystal Nucleation

    7. 14.7Mechanisms of Crystal Growth

    8. 14.8Impurities

    9. 14.9Crystal Perfection

    10. 14.10Concluding Remarks

    11. References

  19. 15Crystallization in Foods

    Richard W. Hartel

    1. 15.1Characteristics of Crystallization in Foods

    2. 15.2Controlling Crystallization in Foods

    3. 15.3Factors Affecting Control of Crystallization in Foods

    4. 15.4Summary

    5. References

  20. 16Precipitation and Crystallization of Pigments

    Lars Vicum, Marco Mazzotti, and Martin Iggland

    1. 16.1Introduction

    2. 16.2Types of Pigments, Pigment Chemistry, and Pigment Properties

    3. 16.3On the Design of Pigment Synthesis Processes

    4. 16.4Practical Applications and Special Aspects

    5. References

  21. Index