The 22q11.2 deletion syndrome (22q11DS) is characterized by high rates of psychotic symptoms and schizophrenia, making this condition a promising human model for studying risk factors for psychosis. We explored the predictive value of ultra high-risk (UHR) criteria in a sample of patients with 22q11DS. We also examined the additional contribution of sociodemographic, clinical and cognitive variables to predict transition to psychosis within a mean interval of 32.56176 months after initial assessment. Eighty-nine participants with 22q11DS (age range: 8–30 years; mean: 16.1647) were assessed using the structured interview for psychosis-risk syndromes. Information on axis I diagnoses, internalizing and externalizing symptoms, level of functioning and IQ was also collected. At baseline, 22 (24.7%) participants met UHR criteria. Compared to those without a UHR condition, they had a significantly lower functioning, more frequent anxiety disorders and more severe psychopathology. Transition rate to psychosis was 27.3% in UHR and 4.5% in non-UHR participants. Cox regression analyses revealed that UHR status significantly predicted conversion to psychosis. Baseline level of functioning was the only other additional predictor. This is the first study investigating the predictive value of UHR criteria in 22q11DS. It indicates that the clinical path leading to psychosis is broadly comparable to that observed in other clinical high-risk samples. Nevertheless, the relatively high transition rate in non-UHR individuals suggests that other risk markers should be explored in this population. The role of low functioning as a predictor of transition to psychosis should also be investigated more in depth.

In this work, we report a preliminary study, based on molecular dynamics simulations, about 3D carbon nanotube networks that could be formed inside the beta zeolites. We investigated their structural stability and mechanical properties. Our results show that from all possible carbon nanotubes that can be embedded inside the channels of the beta zeolite, the one with chirality (6,0) is the most stable. Using the carbon nanotube (6,0), it is possible to build 3D structures with both all (higher density) and only partially (lower density) filled zeolite channels. Under tensile uniaxial force, the 3D low-density carbon nanotube networks are anisotropic and can be stretched along the direction in which all nanotubes are perpendicular up to 130% of strain without fracture. Also, the porosity and network stiffness can be tuned depending on the amount of carbon nanotubes filling the channels of the zeolites.

Recently, a new class of carbon allotrope called protomene was proposed. This new structure is composed of sp2 and sp3 carbon-bonds. Topologically, protomene can be considered as an sp3 carbon structure (∼80% of this bond type) doped by sp2 carbons. First-principles simulations have shown that protomene presents an electronic bandgap of ∼3.4 eV. However, up to now, its mechanical properties have not been investigated. In this work, we have investigated protomene mechanical behavior under tensile strain through fully atomistic reactive molecular dynamics simulations using the ReaxFF force field, as available in the LAMMPS code. At room temperature, our results show that the protomene is very stable and the obtained ultimate strength and ultimate stress indicates an anisotropic behavior. The highest ultimate strength was obtained for the x-direction, with a value of ∼110 GPa. As for the ultimate strain, the highest one was for the z-direction (∼25% of strain) before protomene mechanical fracture.

With the aim to overcome the problems of climatic changes and rising ocean levels, one option is to produce large-scale sustainable energy by nuclear fusion of hydrogen and other very light nuclei similar to the energy source of the sun. Sixty years of worldwide research for the ignition of the heavy hydrogen isotopes deuterium (D) and tritium (T) have come close to a breakthrough for ignition. The problem with the DT fusion is that generated neutrons are producing radioactive waste. One exception as the ideal clean fusion process – without neutron production – is the fusion of hydrogen (H) with the boron isotope 11B11 (B11). In this paper, we have mapped out our research based on recent experiments and simulations for a new energy source. We suggest how HB11 fusion for a reactor can be used instead of the DT option. We have mapped out our HB11 fusion in the following way: (i) The acceleration of a plasma block with a laser beam with the power and time duration of the order of 10 petawatts and one picosecond accordingly. (ii) A plasma confinement by a magnetic field of the order of a few kiloteslas created by a second laser beam with a pulse duration of a few nanoseconds (ns). (iii) The highly increased fusion of HB11 relative to present DT fusion is possible due to the alphas avalanche created in this process. (iv) The conversion of the output charged alpha particles directly to electricity. (v) To prove the above ideas, our simulations show for example that 14 milligram HB11 can produce 300 kWh energy if all achieved results are combined for the design of an absolutely clean power reactor producing low-cost energy.

The application of laser pulses with psec or shorter duration enables nonthermal efficient ultrahigh acceleration of plasma blocks with homogeneous high ion energies exceeding ion current densities of $10^{12}~\text{A}~\text{cm}^{-2}$. The effects of ultrahigh acceleration of plasma blocks with high energy proton beams are proposed for muon production in a compact magnetic fusion device. The proposed new scheme consists of an ignition fusion spark by muon catalyzed fusion ($\unicode[STIX]{x03BC}$CF) in a small mirror-like configuration where low temperature D–T plasma is trapped for a duration of $1~\unicode[STIX]{x03BC}\text{s}$. This initial fusion spark produces sufficient alpha heating in order to initiate the fusion process in the main device. The use of a multi-fluid global particle and energy balance code allows us to follow the temporal evolution of the reaction rate of the fusion process in the device. Recent progress on the ICAN and IZEST projects for high efficient high power and high repetition rate laser systems allows development of the proposed device for clean energy production. With the proposed approaches, experiments on fusion nuclear reactions and $\unicode[STIX]{x03BC}$CF process can be performed in magnetized plasmas in existing kJ$/$PW laser facilities as the GEKKO-LFEX, the PETAL and the ORION or in the near future laser facilities as the ELI-NP Romanian pillar.

Measured highly elevated gains of proton–boron (HB11) fusion (Picciotto et al., Phys. Rev. X 4, 031030 (2014)) confirmed the exceptional avalanche reaction process (Lalousis et al., Laser Part. Beams 32, 409 (2014); Hora et al., Laser Part. Beams 33, 607 (2015)) for the combination of the non-thermal block ignition using ultrahigh intensity laser pulses of picoseconds duration. The ultrahigh acceleration above $10^{20}~\text{cm}~\text{s}^{-2}$ for plasma blocks was theoretically and numerically predicted since 1978 (Hora, Physics of Laser Driven Plasmas (Wiley, 1981), pp. 178 and 179) and measured (Sauerbrey, Phys. Plasmas 3, 4712 (1996)) in exact agreement (Hora et al., Phys. Plasmas 14, 072701 (2007)) when the dominating force was overcoming thermal processes. This is based on Maxwell’s stress tensor by the dielectric properties of plasma leading to the nonlinear (ponderomotive) force $f_{\text{NL}}$ resulting in ultra-fast expanding plasma blocks by a dielectric explosion. Combining this with measured ultrahigh magnetic fields and the avalanche process opens an option for an environmentally absolute clean and economic boron fusion power reactor. This is supported also by other experiments with very high HB11 reactions under different conditions (Labaune et al., Nature Commun. 4, 2506 (2013)).

The laser-induced relativistic shock waves are described. The shock waves can be created directly by a high irradiance laser or indirectly by a laser acceleration of a foil that collides with a second static foil. A special case of interest is the creation of laser-induced fusion where the created alpha particles create a detonation wave. A novel application is suggested with the shock wave or the detonation wave to ignite a pre-compressed target. In particular, the deuterium–tritium fusion is considered. It is suggested that the collision of two laser accelerated foils might serve as a novel relativistic accelerator for bulk material collisions.

Development of a detonation wave due to α heating following short pulse laser irradiation in pre-compressed deuterium–tritium (DT) plasma is considered. The laser parameters required for development of a detonation wave are calculated. We find that a laser irradiance and energy of IL = 1.75 × 1023 W/cm2 and 12.8 kJ accordingly during 1.0 ps in a pre-compressed target at 900 g/cm3 creates an α heating fusion detonation wave. In this case, the nuclear fusion ignition conditions for the pre-compressed DT plasma are achieved along the detonation wave orbit.

In this work, we review some properties of twisted partial actions of Hopf algebras on unital algebras and give necessary and sufficient conditions for a twisted partial action to have a globalization. We also elaborate a series of examples.

This paper suggests a novel route to approach the cold compression curve in laser-plasma induced shock waves. This effect is achieved with a precompression in a diamond anvil cell (DAC). In order to keep the necessary structure of one dimensional shock wave it is required to use a diamond anvil cell with a partially perforated diamond anvil. Precompression pressures of about 50 GPa, that are an order of magnitude higher than the currently reported pressures, are possible to obtain with presentley existing diamond anvil cell technology. The precompressed Hugoniot of Al was calculated for different precompression pressures and it was found that at precompression pressure of 50 GPa the Hugoniot follows the “cold curve” up to about 2 Mbar and 5.2 g/cc. Furthermore, the thermal relative contribution on the Hugoniot curves is calculated.

An overview of the equations of state (EOS) with a short summary of shock wave experiments with laser induced impact flyer, relevant to EOS study, is presented. The “old-new” ellipsometry is suggested and described for the EOS research. The detection of phase transitions of the first kind (solid-solid) as well as phase transition of the second kind (Curie point as an example) is demonstrated. Furthermore, the temperature measurements are not possible without the knowledge of the emissivity, a parameter that can be measured by using ellipsometry techniques.

The inertial confinement fusion (ICF) philosophy is based on high compression. The reasoning is that (a) it is cheaper (energetically) to compress than to heat and (b) nuclear reactions are proportional to density square, therefore the more you compress the better you are in ICF. Of course the only limitations of compression are the hydrodynamic instabilities (like Rayleigh-Taylor, etc). Many of the references in the literature require extremely high compression and in particular the pB11 needs extremely huge compressions. In this paper it is shown that there is an optimum of compression, namely gain G is maximum for a definite compression. The value of this density (for a given fuel mass and particular ICF scheme) depends on the equation of state (EOS). We calculate this value for fast ignition (FI) schemes and compare it with the central spark ignition (CSI) model. The gain calculations are based on the ideal gas for the ions and the Fermi-Dirac EOS for the electrons with an effective alpha, as usually suggested from simulations. The “optimum compression” idea is easily understood from the following argument: From EOS data one needs an infinite energy to compress to an infinite density. Since the energy output is finite it is clear that G is zero for infinite compression. On the other hand for normal density with small fuel mass (~ few mg) the gain is also zero. Therefore a maximum should exist somewhere. For the deuterium-tritium fuel with a mass of few mg one gets an optimum at few hundred g/cc. If you compress more then the gain is going down. So there is a desired maximum compression fixed by EOS. Last but not least, bremsstrahlung losses in degenerate plasma are discussed and the clean fusion (i.e., without neutrons) of proton + B11 → 4α is analyzed.

We investigated the optical properties of pure copper irradiated by a femtosecond laser pulse. Self-absorption of 50-fs laser pulses at 800 nm and 400 nm wavelengths (below and above the interband absorption threshold, respectively) is studied for peak laser intensities up to 1015 W/cm2. Theoretical description of laser interaction with copper target is developed, solving numerically the energy balance equations for electron and ion subsystems together with Maxwell equations for laser radiation field inside the target. The theory accounts for both intraband and interband absorption mechanisms. We treated in detail the changes in electron structure and distribution function with an increase in electron temperature, as well as the ensuing changes in thermodynamic properties, collision frequencies, optical and transport coefficients. Experimental work on self-absorption of femtosecond laser pulses in copper targets at 800 nm and 400 nm wavelengths is ongoing. Results for 800 nm wavelength are reported. Theory and experiment are in good agreement.

Recently a new fast ignitor concept has been proposed by Velarde et al. (2003) that uses only one energy drive. In this concept, the ignition is induced by the collision of high velocity matter accelerated inside a conical guide. The first model used a jet produced by illuminating a conical shape with a laser or X-rays. On the other hand, in the shell impact concept, the compressed deuterium-tritium fuel is ignited by a separately imploded shell traveling in a guiding cone. In this article, we will study the first design, jet driven concept that have been developed during this year. We use for this work the Arwen code (Ogando & Velarde, 2001; Rendleman et al., 2000), with two-dimensional (2D) multi-group radiation transport. The main parameter is to analyze the specific power transmitted to the target during the collision. Problems with the designs are the guide integrity during the collapse, the radiation preheating, and the average efficiency of the process, etc. which we will address as well.

In this paper, we suggest the creation of a nanoparticles and nanotubes by using the interaction of a femtosecond laser with a solid target in a vacuum. A simple model is used to predict the optimal target and the laser parameters for the production of efficient nanoparticles. At the Soreq laboratory, experiments are performed with aluminium and carbon targets using a femtosecond laser. The irradiated targets are composed of either a thin layer of aluminium or of carbon, deposited on a transparent heat-insulating glass substrate. The nanoparticle debris is collected on a silicone wafer for X-ray diffraction (XRD), for scanning electron microscopy (SEM), and for atomic force microscopy (AFM). For transmission electron microscopy (TEM), the debris is caught on a copper grid covered on one side with a carbon membrane. Our experiments confirm the creation of crystal nanoparticles for aluminium and nanotubes for carbon experiments.