Book contents
- Frontmatter
- Contents
- Contributors
- Preface
- 1 Introduction
- 2 Endothelial Mechanotransduction
- 3 Role of the Plasma Membrane in Endothelial Cell Mechanosensation of Shear Stress
- 4 Mechanotransduction by Membrane-Mediated Activation of G-Protein Coupled Receptors and G-Proteins
- 5 Cellular Mechanotransduction: Interactions with the Extracellular Matrix
- 6 Role of Ion Channels in Cellular Mechanotransduction – Lessons from the Vascular Endothelium
- 7 Toward a Modular Analysis of Cell Mechanosensing and Mechanotransduction
- 8 Tensegrity as a Mechanism for Integrating Molecular and Cellular Mechanotransduction Mechanisms
- 9 Nuclear Mechanics and Mechanotransduction
- 10 Microtubule Bending and Breaking in Cellular Mechanotransduction
- 11 A Molecular Perspective on Mechanotransduction in Focal Adhesions
- 12 Protein Conformational Change
- 13 Translating Mechanical Force into Discrete Biochemical Signal Changes
- 14 Mechanotransduction through Local Autocrine Signaling
- 15 The Interaction between Fluid-Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Cell Mechanobiology
- 16 Micro- and Nanoscale Force Techniques for Mechanotransduction
- 17 Mechanical Regulation of Stem Cells
- 18 Mechanotransduction
- 19 Summary and Outlook
- Index
- Plate Section
- References
17 - Mechanical Regulation of Stem Cells
Implications in Tissue Remodeling
Published online by Cambridge University Press: 05 July 2014
Book contents
- Frontmatter
- Contents
- Contributors
- Preface
- 1 Introduction
- 2 Endothelial Mechanotransduction
- 3 Role of the Plasma Membrane in Endothelial Cell Mechanosensation of Shear Stress
- 4 Mechanotransduction by Membrane-Mediated Activation of G-Protein Coupled Receptors and G-Proteins
- 5 Cellular Mechanotransduction: Interactions with the Extracellular Matrix
- 6 Role of Ion Channels in Cellular Mechanotransduction – Lessons from the Vascular Endothelium
- 7 Toward a Modular Analysis of Cell Mechanosensing and Mechanotransduction
- 8 Tensegrity as a Mechanism for Integrating Molecular and Cellular Mechanotransduction Mechanisms
- 9 Nuclear Mechanics and Mechanotransduction
- 10 Microtubule Bending and Breaking in Cellular Mechanotransduction
- 11 A Molecular Perspective on Mechanotransduction in Focal Adhesions
- 12 Protein Conformational Change
- 13 Translating Mechanical Force into Discrete Biochemical Signal Changes
- 14 Mechanotransduction through Local Autocrine Signaling
- 15 The Interaction between Fluid-Wall Shear Stress and Solid Circumferential Strain Affects Endothelial Cell Mechanobiology
- 16 Micro- and Nanoscale Force Techniques for Mechanotransduction
- 17 Mechanical Regulation of Stem Cells
- 18 Mechanotransduction
- 19 Summary and Outlook
- Index
- Plate Section
- References
Summary
Introduction
Stem cells, which can self-renew and differentiate into cells with specialized functions, are usually classified as embryonic stem cells (ESCs) and adult stem cells. ESCs are derived from the inner cell mass of a blastocyst, can self-renew indefinitely, and can give rise to cell types of all somatic lineages from the three embryonic germ layers. Adult stem cells have been found in many types of tissues and organs such as bone marrow, blood, muscle, skin, intestine, fat, and brain. Bone marrow is one of the most abundant sources of adult stem cells and progenitor cells. Mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), and endothelial progenitor cells (EPCs) can be isolated from bone marrow. These bone marrow MSCs are pluripotent stromal cells. MSCs can be expanded into billions of folds in culture, and can be stimulated to differentiate into a variety of cell types. HSCs give rise to blood cells. These cells, along with EPCs, are mobilized in response to growth factors and cytokines released upon injury in tissues and organs, and therefore can be isolated from peripheral blood in addition to the bone marrow. Both embryonic stem cells and adult stem cells have tremendous potential for cell therapy and tissue repair.
- Type
- Chapter
- Information
- Cellular MechanotransductionDiverse Perspectives from Molecules to Tissues, pp. 403 - 416Publisher: Cambridge University PressPrint publication year: 2009
References
. and , Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int, 1995. 57(5): 344–58.CrossRefGoogle ScholarPubMed
. and , Mechanical strain and bone cell function: A review. Osteoporos Int, 2002. 13(9): 688–700.CrossRefGoogle ScholarPubMed
. and , Mechanical stresses and endochondral ossification in the chondroepiphysis. J Orthop Res, 1988. 6(1): 148–54.CrossRefGoogle ScholarPubMed
. and , A theoretical model of endochondral ossification and bone architectural construction in long bone ontogeny. Anat Embryol (Berl), 1990. 181(6): 523–32.CrossRefGoogle ScholarPubMed
., et al., Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells. Circ Res, 1996. 79(5): 1046–53.CrossRefGoogle ScholarPubMed
., et al., Stretch-induced proliferation of cultured vascular smooth muscle cells and a possible involvement of local renin-angiotensin system and platelet-derived growth factor (PDGF). Hypertens Res, 1997. 20(3): 217–23.CrossRefGoogle Scholar
., , and , Mechanical stress induced cellular orientation and phenotypic modulation of three dimensional cultured smooth muscle cells. Asaio J, 1993. 39(3): M686–90.Google Scholar
., et al., Stretch affects phenotype and proliferation of vascular smooth muscle cells. Mol Cell Biochem, 1995. 144(2): 131–9.CrossRefGoogle ScholarPubMed
., et al., Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase. Biochem Biophys Res Commun, 2003. 301(4): 1116–21.CrossRefGoogle ScholarPubMed
., , and , Modulation of IGF mRNA abundance during stretch-induced skeletal muscle hypertrophy and regression. J Appl Physiol, 1994. 76(5): 2026–30.CrossRefGoogle ScholarPubMed
., et al., Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch. J Anat, 1997. 190(Pt 4): 613–22.CrossRefGoogle Scholar
., et al., Effect of isometric strength training of mechanical, electrical, and metabolic aspects of muscle function. Eur J Appl Physiol Occup Physiol, 1978. 40(1): 45–55.CrossRefGoogle Scholar
. and , Alterations of mechanical characteristics of human skeletal muscle during strength training. Eur J Appl Physiol Occup Physiol, 1983. 50(2): 161–72.CrossRefGoogle ScholarPubMed
., Biomechanics of the Normal and Diseased Hip. 1976, Berlin: Springer-Verlag.CrossRefGoogle Scholar
., Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res, 1979. 138: 175–96.Google Scholar
., The mechanostat: A proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents. Bone Miner, 1987. 2(2): 73–85.Google ScholarPubMed
., , and , Role of mechanical loading in the progressive ossification of a fracture callus. J Orthop Res, 1989. 7(3): 398–407.CrossRefGoogle ScholarPubMed
., Mechanical loading history and skeletal biology. J Biomech, 1987. 20(11–12): 1095–109.CrossRefGoogle ScholarPubMed
., , and , Correlations between mechanical stress history and tissue differentiation in initial fracture healing. J Orthop Res, 1988. 6(5): 736–48.CrossRefGoogle ScholarPubMed
., , and , ESB Research Award 1996. Biophysical stimuli on cells during tissue differentiation at implant interfaces. J Biomech, 1997. 30(6): 539–48.CrossRefGoogle ScholarPubMed
., et al., The effect of mechanical strain on proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells from rats. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2006. 23(3): 542–5.Google ScholarPubMed
., et al., Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech, 2003. 36(8): 1087–96.CrossRefGoogle ScholarPubMed
., et al., Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch. Cardiovasc Res, 2006. 71(3): 548–56.CrossRefGoogle ScholarPubMed
., et al., Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation. Faseb J, 2006. 20(8): 1182–4.CrossRefGoogle ScholarPubMed
., et al., Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells. Biotechnol Bioeng, 2004. 88(3): 359–68.CrossRefGoogle ScholarPubMed
., , and , Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: Implications for vascular tissue-engineering applications. Tissue Eng, 2004. 10(3–4): 361–9.CrossRefGoogle ScholarPubMed
., , and , Two-dimensional orientational response of smooth muscle cells to cyclic stretching. Asaio J, 1992. 38(3): M382–5.CrossRefGoogle ScholarPubMed
., et al., Anisotropic mechanosensing by mesenchymal stem cells. Proc Natl Acad Sci USA, 2006. 103(44): 16095–100.CrossRefGoogle ScholarPubMed
., , and , Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year. J Bone Joint Surg Am, 1988. 70(4): 595–606.CrossRefGoogle ScholarPubMed
., et al., Repair of large full-thickness articular cartilage defects with allograft articular chondrocytes embedded in a collagen gel. Tissue Eng, 1998. 4(4): 429–44.CrossRefGoogle Scholar
. and , Cartilage induction by controlled mechanical stimulation in vivo. J Orthop Res, 1999. 17(2): 200–4.CrossRefGoogle ScholarPubMed
., , and , Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. Biorheology, 2006. 43(3–4): 455–70.Google ScholarPubMed
., et al., Effect of compressive loading on chondrocyte differentiation in agarose cultures of chick limb-bud cells. J Orthop Res, 2000. 18(1): 78–86.CrossRefGoogle ScholarPubMed
., et al., Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Ann Biomed Eng, 2001. 29(6): 476–82.CrossRefGoogle ScholarPubMed
., et al., Effects of cyclic compressive loading on chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells. Stem Cells, 2004. 22(3): 313–23.CrossRefGoogle ScholarPubMed
., , and , Temporal expression patterns and corresponding protein inductions of early responsive genes in rabbit bone marrow-derived mesenchymal stem cells under cyclic compressive loading. Stem Cells, 2005. 23(8): 1113–21.CrossRefGoogle ScholarPubMed
., et al., Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading. Biomech Model Mechanobiol, 2007. 6(1–2): 113–25.CrossRefGoogle ScholarPubMed
., et al., Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro. J Orthop Res, 2003. 21(3): 451–7.CrossRefGoogle ScholarPubMed
., et al., Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds. Biorheology, 2004. 41(3–4): 335–46.Google ScholarPubMed
., et al., Compressive force promotes sox9, type II collagen and aggrecan and inhibits IL-1beta expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells. J Cell Sci, 1998. 111(Pt 14): 2067–76.Google ScholarPubMed
., et al., Cell differentiation by mechanical stress. Faseb J, 2002. 16(2): 270–2.CrossRefGoogle ScholarPubMed
., et al., Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading. J Artif Organs, 2005. 8(2): 110–8.CrossRefGoogle ScholarPubMed
., et al., Matrix elasticity directs stem cell lineage specification. Cell, 2006. 126(4): 677–89.CrossRefGoogle ScholarPubMed
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