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Chapter 59 - Cytomegalovirus Infection in Pregnancy

from Section 11 - Infectious Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Amira El-Messidi  and
Eva Suarthana
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A healthy 23-year-old G2P1 presents for prenatal care at 12+0 weeks’ gestation by dating ultrasound. Her last pregnancy was cared for by your colleague, who is currently away. Pregnancy was uncomplicated, and she had a spontaneous vaginal delivery at term. You learn from the antenatal notes that the patient had a flu-like illness in early pregnancy; investigations were unremarkable, and symptoms resolved with supportive care. She tells you her healthy two-year-old son has been attending daycare since six months of age and is meeting his developmental milestones.

Keywords

Cytomegalovirus, pregnancyRisk factorsLifestyle measures, preventionFetal diagnosis, sonography, short-term morbidity, long-term morbidity, congenital infectionInvestigationsDiagnosis, maternal serology, avidity testing, polymerase chain reaction (PCR)CounselingMaternal therapyUniversal screening testSensitivity, specificity, relative risk, calculation, area under the curve
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 763 - 773
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Bartlett, AW, Hamilton, ST, Shand, AW, et al. Fetal therapies for cytomegalovirus: what we tell prospective parents. Prenat Diagn. 2020;1–12.CrossRefGoogle Scholar
Boucoiran, I, Yudin, M, Poliquin, V, et al. Guideline No. 420: cytomegalovirus infection in pregnancy. J Obstet Gynaecol Can. 2021;43(7):893–908. [Correction in J Obstet Gynaecol Can. 2021 Oct 11]Google Scholar
Bonita, R, Beaglehole, R, Kjellström, T. Basic Epidemiology. 2nd ed. Geneva: WHO; 2016.Google Scholar
Gaur, P, Ffrench-Constant, S, Kachramanoglou, C, et al. Is it not time for international guidelines to combat congenital cytomegalovirus infection? a review of central nervous system manifestations. Clin Radiol. 2020;75(8): 644.Google Scholar
Kagan, KO, Hamprecht, K. Cytomegalovirus infection in pregnancy. Arch Gynecol Obstet. 2017;296(1):15–26.Google Scholar
Khalil, A, Heath, P, Jones, C, et al. Congenital cytomegalovirus infection: update on treatment: Scientific Impact Paper No. 56. BJOG. 2018;125(1):e1–e11.Google Scholar
Lazzarotto, T, Blázquez-Gamero, D, Delforge, ML, et al. Congenital cytomegalovirus infection: a narrative review of the issues in screening and management from a panel of European experts. Front Pediatr. 2020;8:13.Google Scholar
Leruez-Ville, M, Ville, Y. Fetal cytomegalovirus infection. Best Pract Res Clin Obstetr Gynaecol 2017;38:97–107.CrossRefGoogle ScholarPubMed
Rawlinson, WD, Boppana, SB, Fowler, KB, et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis. 2017;17(6):e177–e188.CrossRefGoogle ScholarPubMed
Society for Maternal-Fetal Medicine (SMFM), Hughes, BL, Gyamfi-Bannerman, C. Diagnosis and antenatal management of congenital cytomegalovirus infection. Am J Obstet Gynecol. 2016;214(6):B5–B11.CrossRefGoogle ScholarPubMed

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