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Chapter 65 - Syphilis in Pregnancy

from Section 11 - Infectious Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 23-year-old primigravida is referred to your high-risk obstetrics clinic at 17+3 weeks’ gestation for a reactive VDRL test on routine prenatal screening. Although her appointment with you is in two days, she presents urgently to your office for new-onset tongue lesions and a rash. She had an early dating sonography, and aneuploidy screening was unremarkable. She takes prenatal vitamins and has no obstetric complaints.

Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
, pp. 831 - 842
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Adhikari, EH. Syphilis in pregnancy. Obstet Gynecol. 2020 May;135(5):11211135.Google Scholar
Centers for Disease Control and Prevention. Syphilis (Treponema pallidum) 2018 case definition. Available at wwwn.cdc.gov/nndss/conditions/syphilis/case-definition/2018/. Accessed October 17, 2020.Google Scholar
Ghanem, KG, Ram, S, Rice, PA. The modern epidemic of syphilis. N Engl J Med. 2020 Feb 27;382(9):845854.Google Scholar
Janier, M, Unemo, M, Dupin, N, Tiplica, GS, Potočnik, M, Patel, R, 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2021 Mar;35(3):574588.CrossRefGoogle ScholarPubMed
Kingston, M, Fifer, H, French, P, et al. Amendment to the UK guidelines on the management of syphilis 2015: Management of syphilis in pregnant women. Int J STD AIDS. 2019 Nov;30(13):13441345.Google Scholar
Public Health Agency of Canada. Canadian guidelines on sexually transmitted infections: management and treatment of specific infections – syphilis. Available at www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines/syphilis.html. Accessed October 14, 2020.Google Scholar
Trinh, T, Leal, AF, Mello, MB, et al. Syphilis management in pregnancy: a review of guideline recommendations from countries around the world. Sex Reprod Health Matters. 2019 Dec;27(1):6982.CrossRefGoogle ScholarPubMed
UK Standards for Microbiology Investigations. Syphilis Serology. Virology 2016; 44(2.1).Google Scholar
WHO. Guideline on Syphilis Screening and Treatment for Pregnant Women. Geneva: World Health Organization; 2017.Google Scholar
Workowski, KA, Bolan, GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1137. [Erratum in MMWR Recomm Rep. 2015 Aug 28;64(33):924]Google ScholarPubMed

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